scholarly journals 3D Printing of Mini Tablets for Pediatric Use

2021 ◽  
Vol 14 (2) ◽  
pp. 143
Author(s):  
Julius Krause ◽  
Laura Müller ◽  
Dorota Sarwinska ◽  
Anne Seidlitz ◽  
Malgorzata Sznitowska ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Dosage Forms ◽  
Small Scale ◽  
Fused Deposition ◽  
On Demand ◽  
Pediatric Diseases ◽  
Deposition Modeling ◽  
Manufacturing Techniques ◽  
Pediatric Use

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

scholarly journals Experience of implementation in educational process modern technologies of FDM 3D printing

2021 ◽  
pp. 55-59
Author(s):  
Petr Andrienko ◽  
Vladimir Vasilevskij ◽  
Ivan Vittsivskyi
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Current Transformer ◽  
Educational Process ◽  
Small Scale ◽  
Thermoplastic Material ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Modern Technologies

Fused Deposition Modeling is an additive manufacturing technology where a temperature-controlled head extrudes a thermoplastic material onto a build platform in a predetermined path. Standard, advanced thermoplastics and composites are used for printing. Among the areas of application for FDM printing, the main ones are rapid prototyping, as well as small-scale and batch production. The purpose of the work is the implementation of FDM 3D printing technology in the educational process of students in specialty 141 "Electroenergy, electrotechnics and electromechanics". The features of the technology of additive manufacturing of electrical apparatuses parts by the method of FDM printing have been investigated. Parts of four standard sizes were printed using ABS + and PLA plastics, namely, current transformer carcasses in the amount of 110 pieces and sensor bodies in the amount of 100 pieces. For printing, an FDM 3D printer was used built on the XZ Head Y Bed kinematic scheme with an open working chamber. The analysis of defects in finished products was carried out, which showed that the main defects are deviations of the actual dimensions and geometric shape of the finished products. Ways to prevent the occurrence of these defects are considered, namely, correcting the size of the model at the stage of preparing the model for printing, minimizing the filling density of the model, using brims in models, setting the optimal temperature of the working platform and simultaneously printing several products. The results of the study o features of the technology of additive manufacturing of electrical apparatuses parts by the method of FDM printing made it possible to develop a set of laboratory works for students of the specialty 141 "Electroenergy, electrotechnics and electromechanics".

scholarly journals Laboratory 3D printing system

2018 ◽  
Vol 7 (2.23) ◽  
pp. 68 ◽  
Author(s):  
Anton V. Mironov ◽  
Aleksandra O. Mariyanac ◽  
Olga A. Mironova ◽  
Vladimir K. Popov
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Uv Laser ◽  
Universal System ◽  
Fused Deposition ◽  
On Demand ◽  
Drop On Demand ◽  
Different Types ◽  
Deposition Modeling ◽  
Printing System

Present work describes the results of the development of the universal system, which capable to utilize varies 3D printing methodologies. The main goal of the study is to provide cheap, versatile and easy expandable equipment for multiple purpose research in the field of material science. 3D printing system was experimentally validated for fused deposition modeling, hydrogel, liquid dispensing and drop-on-demand printing, as well as 3D photopolymerisation by UV laser and/or LED light using different types of materials.  

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

2019 ◽  
Vol 24 (42) ◽  
pp. 4991-5008 ◽  
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad
Keyword(s):  
Cosmetic Surgery ◽  
Fused Deposition Modeling ◽  
Personalised Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Release Profile ◽  
Small Scale ◽  
Drug Release Profile ◽  
Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

Influence of Part Orientation on the Surface Roughness in the Process of Fused Deposition Modeling

2021 ◽  
Vol 896 ◽  
pp. 29-37
Author(s):  
Ján Milde ◽  
František Jurina ◽  
Jozef Peterka ◽  
Patrik Dobrovszký ◽  
Jakub Hrbál ◽  
...  
Keyword(s):  
Surface Roughness ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Orientation Angle ◽  
Acrylonitrile Butadiene Styrene ◽  
Lower Surface ◽  
Geometrical Model ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Part Orientation

The article focused on the influence of part orientation on the surface roughness of cuboid parts during the process of fabricating by FDM technology. The components, in this case, is simple cuboid part with the dimensions 15 mm x 15mm x 30 mm. A geometrical model is defined that considers the shape of the material filaments after deposition, to define a theoretical roughness profile, for a certain print orientation angle. Five different print orientations in the X-axis of the cuboid part were set: 0°, 30°, 45°, 60°, and 90°. According to previous research in the field of FDM technology by the author, the internal structure (infill) was set at the value of 70%. The method of 3D printing was the Fused Deposition Modeling (FDM) and the material used in this research was thermoplastic ABS (Acrylonitrile butadiene styrene). For each setting, there were five specimens (twenty five prints in total). Prints were fabricated on a Zortrax M200 3D printer. After the 3D printing, the surface “A” was investigated by portable surface roughness tester Mitutoyo SJ-210. Surface roughness in the article is shown in the form of graphs (Fig.7). Results show increase in part roughness with increasing degree of part orientation. When the direction of applied layers on the measured surface was horizontal, significant improvement in surface roughness was observed. Findings in this paper can be taken into consideration when designing parts, as they can contribute in achieving lower surface roughness values.

Understanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic devices

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Reverson Fernandes Quero ◽  
Gessica Domingos Silveira ◽  
Jose Alberto Fracassi da Silva ◽  
Dosil Pereira de Jesus
Keyword(s):  
High Resolution ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Microfluidic Devices ◽  
Fused Deposition ◽  
Optically Transparent ◽  
Deposition Modeling

The fabrication of microfluidic devices through Fused Deposition Modeling (FDM) 3D printing has faced several challenges, mainly regarding obtaining microchannels with suitable transparency and sizes. Thus, the use of this...

Sign in / Sign up

Export Citation Format

Share Document