Changes in behavioral functions after progenitor cell transplantation therapy of hypoxic and ischemic brain injury in neonatal and adult rat

2008 ◽  
Vol 69 (3) ◽  
pp. 316
Author(s):  
S.V. Lebedev ◽  
I.V. Viktorov ◽  
A.I. Volkov ◽  
A.V. Karasev ◽  
N.N. Volodin ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cell Transplantation ◽  
Progenitor Cell ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Adult Rat ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

Caspase-1-independent Maturation of IL-1? in Ischemic Brain Injury: is there a Role for Gelatinases?

2016 ◽  
Vol 16 (9) ◽  
pp. 729-737 ◽  
Author(s):  
Diana Amantea ◽  
Rossella Russo ◽  
Michelangelo Certo ◽  
Laura Rombolà ◽  
Annagrazia Adornetto ◽  
...  
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Caspase 1

scholarly journals Nilvadipine, a New Calcium Channel Blocker, Reduces Ischemic Brain Injury in Rats

1991 ◽  
Vol 56 (4) ◽  
pp. 547-550
Author(s):  
Shoji Takakura ◽  
Teruo Susumu ◽  
Hisashi Satoh ◽  
Jo Mori ◽  
Akihiko Shiino ◽  
...  
Keyword(s):  
Brain Injury ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

scholarly journals Neural stem cells: involvement in adult neurogenesis and CNS repair

2008 ◽  
Vol 363 (1500) ◽  
pp. 2111-2122 ◽  
Author(s):  
Hideyuki Okano ◽  
Kazunobu Sawamoto
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cell Transplantation ◽  
Adult Neurogenesis ◽  
Embryonic Stem ◽  
Adult Brain ◽  
Therapeutic Interventions ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

Recent advances in stem cell research, including the selective expansion of neural stem cells (NSCs) in vitro , the induction of particular neural cells from embryonic stem cells in vitro , the identification of NSCs or NSC-like cells in the adult brain and the detection of neurogenesis in the adult brain (adult neurogenesis), have laid the groundwork for the development of novel therapies aimed at inducing regeneration in the damaged central nervous system (CNS). There are two major strategies for inducing regeneration in the damaged CNS: (i) activation of the endogenous regenerative capacity and (ii) cell transplantation therapy. In this review, we summarize the recent findings from our group and others on NSCs, with respect to their role in insult-induced neurogenesis (activation of adult NSCs, proliferation of transit-amplifying cells, migration of neuroblasts and survival and maturation of the newborn neurons), and implications for therapeutic interventions, together with tactics for using cell transplantation therapy to treat the damaged CNS.

Sign in / Sign up

Export Citation Format

Share Document