scholarly journals One-Time Treatment of Ketamine Alleviate Fear Memory and Spatial Cognition Deficits in PTSD Rat Models via BDNF Signaling and Post-Synaptic Density 95 of Hippocampus and Amygdala

2021 ◽  
Vol 168 ◽  
pp. S166
Author(s):  
Jiayao Niu ◽  
Haonan Li ◽  
Yu Li ◽  
Jiaming Sun ◽  
Bo Lian ◽  
...  
Keyword(s):  
Spatial Cognition ◽  
Fear Memory ◽  
Synaptic Density ◽  
Rat Models ◽  
Time Treatment ◽  
Bdnf Signaling ◽  
Post Synaptic Density

Berberine Alleviates Amyloid-beta Pathogenesis Via Activating LKB1/AMPK Signaling in the Brain of APP/PS1 Transgenic Mice

2019 ◽  
Vol 19 (5) ◽  
pp. 342-348 ◽  
Author(s):  
Zhi-You Cai ◽  
Chuan-Ling Wang ◽  
Tao-Tao Lu ◽  
Wen-Ming Yang
Keyword(s):  
Transgenic Mice ◽  
Western Blotting ◽  
Amyloid Β ◽  
Adenosine Monophosphate ◽  
Camp Response Element Binding ◽  
Enzyme Linked Immunosorbent Assay ◽  
Synaptic Density ◽  
Ampk Signaling ◽  
The Brain ◽  
Post Synaptic Density

Background:Liver kinase B1 (LKB1)/5’-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer’s disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine (BBR) activates LKB1/AMPK signaling and ameliorates Aβ pathology.Methods:The Aβ levels were detected using enzyme-linked immunosorbent assay and immunohistochemistry. The following biomarkers were measured by Western blotting: phosphorylated (p-) LKB1 (Ser334 and Thr189), p-AMPK (AMPKα and AMPKβ1), synaptophysin, post-synaptic density protein 95 and p-cAMP-response element binding protein (p-CREB). The glial fibrillary acidic protein (GFAP) was determined using Western blotting and immunohistochemistry.Results:BBR inhibited Aβ expression in the brain of APP/PS1 mice. There was a strong up-regulation of both p-LKB1 (Ser334 and Thr189) and p-AMPK (AMPKα and AMPKβ1) in the brains of APP/PS1 transgenic mice after BBR-treatment (P<0.01). BBR promoted the expression of synaptophysin, post-synaptic density protein 95 and p-CREB(Ser133) in the AD brain, compared with the model mice.Conclusion:BBR alleviates Aβ pathogenesis and rescues synapse damage via activating LKB1/AMPK signaling in the brain of APP/PS1 transgenic mice.

scholarly journals Myosin IIB Activity and Phosphorylation Status Determines Dendritic Spine and Post-Synaptic Density Morphology

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e24149 ◽  
Author(s):  
Jennifer L. Hodges ◽  
Karen Newell-Litwa ◽  
Hannelore Asmussen ◽  
Miguel Vicente-Manzanares ◽  
Alan Rick Horwitz
Keyword(s):  
Dendritic Spine ◽  
Synaptic Density ◽  
Post Synaptic Density

Glycoproteins of the post-synaptic density: biochemical and immunochemical characterization of PSD-GP180

1992 ◽  
Vol 20 (2) ◽  
pp. 379-382 ◽  
Author(s):  
J. W. Gurd ◽  
I. R. Brown ◽  
N. Bissoon ◽  
S. Cudmore ◽  
B. Ni ◽  
...  
Keyword(s):  
Synaptic Density ◽  
Immunochemical Characterization ◽  
Post Synaptic Density

Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain

2012 ◽  
Vol 124 (3) ◽  
pp. 383-394 ◽  
Author(s):  
Naoya Aoki ◽  
Shinji Higashi ◽  
Ito Kawakami ◽  
Zen Kobayashi ◽  
Masato Hosokawa ◽  
...  
Keyword(s):  
Synaptic Density ◽  
Fused In Sarcoma ◽  
The Brain ◽  
Post Synaptic Density ◽  
Fus Protein

Calcium- and calmodulin-dependent phosphorylation of AMPA type glutamate receptor subunits by endogenous protein kinases in the post-synaptic density

1997 ◽  
Vol 46 (1-2) ◽  
pp. 338-342 ◽  
Author(s):  
Yasunori Hayashi ◽  
Atsuhiko Ishida ◽  
Hiroyuki Katagiri ◽  
Masayoshi Mishina ◽  
Hitoshi Fujisawa ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Glutamate Receptor ◽  
Synaptic Density ◽  
Endogenous Protein ◽  
Post Synaptic Density

The glutamate receptor 2 subunit controls post-synaptic density complexity and spine shape in the dentate gyrus

2008 ◽  
Vol 27 (2) ◽  
pp. 315-325 ◽  
Author(s):  
Nikolay I. Medvedev ◽  
José J. Rodríguez-Arellano ◽  
Victor I. Popov ◽  
Heather A. Davies ◽  
Cezar M. Tigaret ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Glutamate Receptor ◽  
Synaptic Density ◽  
Spine Shape ◽  
Post Synaptic Density
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