The sensitivity of human mesenchymal stem cells to ionizing radiation

2006 ◽  
Vol 66 (1) ◽  
pp. 244-253 ◽  
Author(s):  
Miao-Fen Chen ◽  
Ching-Tai Lin ◽  
Wen-Cheng Chen ◽  
Cheng-Ta Yang ◽  
Chih-Cheng Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ionizing Radiation ◽  
Human Mesenchymal Stem Cells

scholarly journals Effect of Low-Dose Ionizing Radiation on the Expression of Mitochondria-Related Genes in Human Mesenchymal Stem Cells

2021 ◽  
Vol 23 (1) ◽  
pp. 261
Author(s):  
Svetlana V. Kostyuk ◽  
Elena V. Proskurnina ◽  
Marina S. Konkova ◽  
Margarita S. Abramova ◽  
Andrey A. Kalianov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ionizing Radiation ◽  
Low Dose ◽  
Human Mesenchymal Stem Cells ◽  
Mitochondrial Respiratory Chain ◽  
Respiratory Chain Complexes ◽  
Cell Free Dna ◽  
X Ray ◽  
Free Dna

The concept of hormesis describes a phenomenon of adaptive response to low-dose ionizing radiation (LDIR). Similarly, the concept of mitohormesis states that the adaptive program in mitochondria is activated in response to minor stress effects. The mechanisms of hormesis effects are not clear, but it is assumed that they can be mediated by reactive oxygen species. Here, we studied effects of LDIR on mitochondria in mesenchymal stem cells. We have found that X-ray radiation at a dose of 10 cGy as well as oxidized fragments of cell-free DNA (cfDNA) at a concentration of 50 ng/mL resulted in an increased expression of a large number of genes regulating the function of the mitochondrial respiratory chain complexes in human mesenchymal stem cells (MSC). Several genes remained upregulated within hours after the exposure. Both X-ray radiation and oxidized cfDNA resulted in upregulation of FIS1 and MFN1 genes, which regulated fusion and fission of mitochondria, within 3–24 h after the exposure. Three hours after the exposure, the number of copies of mitochondrial DNA in cells had increased. These findings support the hypothesis that assumes oxidized cell-free DNA as a mediator of MSC response to low doses of radiation.

Transformation of human mesenchymal stem cells in radiation carcinogenesis: long-term effect of ionizing radiation

2008 ◽  
Vol 3 (6) ◽  
pp. 849-861 ◽  
Author(s):  
Rikke Christensen ◽  
Jan Alsner ◽  
Flemming Brandt Sorensen ◽  
Frederik Dagnaes-Hansen ◽  
Steen Kolvraa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ionizing Radiation ◽  
Human Mesenchymal Stem Cells ◽  
Term Effect ◽  
Radiation Carcinogenesis ◽  
Long Term Effect

scholarly journals Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation

2019 ◽  
Vol 33 (8) ◽  
pp. 9263-9278 ◽  
Author(s):  
David A. Patten ◽  
Mathieu Ouellet ◽  
David S. Allan ◽  
Marc Germain ◽  
Stephen D. Baird ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ionizing Radiation ◽  
Human Mesenchymal Stem Cells ◽  
Mitochondrial Adaptation

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

The Effect of Link N on the Differentiation of Human Mesenchymal Stem Cells

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1320001-s-0032-1320001
Author(s):  
F. Mwale ◽  
H. T. Wang ◽  
L. Haglund ◽  
P. J. Roughley ◽  
J. Antoniou
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Generation of human mesenchymal stem cells lacking diabetoporosity-associated miRNAs using CRISPR/Cas9

2020 ◽  
Author(s):  
I Foessl ◽  
A Groselj-Strele ◽  
JC Piswanger-Sölkner ◽  
H Dobnig ◽  
A Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells
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