Effect of Recombinant Human Keratinocyte Growth Factor (rHuKGF, Palifermin) on Radiation-Induced Mouse Urinary Bladder Dysfunction

2007 ◽  
Vol 69 (2) ◽  
pp. 528-533 ◽  
Author(s):  
Jana Jaal ◽  
Wolfgang Dörr
Keyword(s):  
Growth Factor ◽  
Urinary Bladder ◽  
Bladder Dysfunction ◽  
Keratinocyte Growth Factor ◽  
Urinary Bladder Dysfunction ◽  
Human Keratinocyte ◽  
Radiation Induced

The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats

2004 ◽  
Vol 60 (5) ◽  
pp. 1520-1529 ◽  
Author(s):  
Liguang Chen ◽  
David M. Brizel ◽  
Zahid N. Rabbani ◽  
Thaddeus V. Samulski ◽  
Catherine L. Farrell ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protective Effect ◽  
Pulmonary Toxicity ◽  
Keratinocyte Growth Factor ◽  
Human Keratinocyte ◽  
Radiation Induced

An evaluation of the effect of bortezomib on radiation-induced urinary bladder dysfunction

2019 ◽  
Vol 195 (10) ◽  
pp. 934-939 ◽  
Author(s):  
Sina Sarsarshahi ◽  
Zahra Madjd ◽  
Eva Bozsaky ◽  
Jakob Kowaliuk ◽  
Peter Kuess ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bladder Dysfunction ◽  
Urinary Bladder Dysfunction ◽  
Radiation Induced

scholarly journals Social stress induces changes in urinary bladder function, bladder NGF content, and generalized bladder inflammation in mice

2014 ◽  
Vol 307 (7) ◽  
pp. R893-R900 ◽  
Author(s):  
Gerald C. Mingin ◽  
Abbey Peterson ◽  
Cuixia Shi Erickson ◽  
Mark T. Nelson ◽  
Margaret A. Vizzard
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Urinary Bladder ◽  
Protein Expression ◽  
Social Stress ◽  
Bladder Dysfunction ◽  
Bladder Capacity ◽  
Bladder Function ◽  
Nerve Growth ◽  
Urinary Bladder Dysfunction

Social stress may play a role in urinary bladder dysfunction in humans, but the underlying mechanisms are unknown. In the present study, we explored changes in bladder function caused by social stress using mouse models of stress and increasing stress. In the stress paradigm, individual submissive FVB mice were exposed to C57BL/6 aggressor mice directly/indirectly for 1 h/day for 2 or 4 wk. Increased stress was induced by continuous, direct/indirect exposure of FVB mice to aggressor mice for 2 wk. Stressed FVB mice exhibited nonvoiding bladder contractions and a decrease in both micturition interval (increased voiding frequency) and bladder capacity compared with control animals. ELISAs demonstrated a significant increase in histamine protein expression with no change in nerve growth factor protein expression in the urinary bladder compared with controls. Unlike stressed mice, mice exposed to an increased stress paradigm exhibited increased bladder capacities and intermicturition intervals (decreased voiding frequency). Both histamine and nerve growth factor protein expression were significantly increased with increased stress compared with control bladders. The change in bladder function from increased voiding frequency to decreased voiding frequency with increased stress intensity suggests that changes in social stress-induced urinary bladder dysfunction are context and duration dependent. In addition, changes in the bladder inflammatory milieu with social stress may be important contributors to changes in urinary bladder function.

scholarly journals EP-1809: Effect of thalidomide on radiation-induced urinary bladder dysfunction

2017 ◽  
Vol 123 ◽  
pp. S993
Author(s):  
J. Kowaliuk ◽  
E. Bozsaky ◽  
S. Sarsarshahi ◽  
P. Kuess ◽  
W. Dörr
Keyword(s):  
Urinary Bladder ◽  
Bladder Dysfunction ◽  
Urinary Bladder Dysfunction ◽  
Radiation Induced

Prevalence and Physician Awareness of Symptoms of Urinary Bladder Dysfunction

2002 ◽  
Vol 41 (3) ◽  
pp. 234-239 ◽  
Author(s):  
Mark Goepel ◽  
Josef A. Hoffmann ◽  
Maria Piro ◽  
Herbert Rübben ◽  
Martin C. Michel
Keyword(s):  
Urinary Bladder ◽  
Bladder Dysfunction ◽  
Urinary Bladder Dysfunction ◽  
Physician Awareness
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