scholarly journals Intratracheal Administration of Recombinant Human Keratinocyte Growth Factor Promotes Alveolar Epithelial Cell Proliferation during Compensatory Lung Growth in Rat

2013 ◽  
Vol 46 (6) ◽  
pp. 179-185 ◽  
Author(s):  
Katsuro Furukawa ◽  
Keitaro Matsumoto ◽  
Takeshi Nagayasu ◽  
Tomomi Yamamoto-Fukuda ◽  
Shuichi Tobinaga ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Epithelial Cell ◽  
Alveolar Epithelial Cell ◽  
Keratinocyte Growth Factor ◽  
Epithelial Cell Proliferation ◽  
Lung Growth ◽  
Intratracheal Administration ◽  
Alveolar Epithelial ◽  
Human Keratinocyte

Keratinocyte Growth Factor Modulates Alveolar Epithelial Cell PhenotypeIn Vitro: Expression of Aquaporin 5

1998 ◽  
Vol 18 (4) ◽  
pp. 554-561 ◽  
Author(s):  
Zea Borok ◽  
Richard L. Lubman ◽  
Spencer I. Danto ◽  
Xiao-Ling Zhang ◽  
Stephanie M. Zabski ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cell ◽  
Alveolar Epithelial Cell ◽  
Keratinocyte Growth Factor ◽  
Aquaporin 5 ◽  
Alveolar Epithelial

scholarly journals Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 389 ◽  
Author(s):  
Kaj E. C. Blokland ◽  
David W. Waters ◽  
Michael Schuliga ◽  
Jane Read ◽  
Simon D. Pouwels ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Wound Repair ◽  
Alveolar Epithelial Cell ◽  
Lung Parenchyma ◽  
Repair Process ◽  
Lung Fibroblasts ◽  
Epithelial Cell Proliferation ◽  
Alveolar Epithelial ◽  
M Phase

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by excessive accumulation of lung fibroblasts (LFs) and collagen in the lung parenchyma. The mechanisms that underlie IPF pathophysiology are thought to reflect repeated alveolar epithelial injury leading to an aberrant wound repair response. Recent work has shown that IPF-LFs display increased characteristics of senescence including growth arrest and a senescence-associated secretory phenotype (SASP) suggesting that senescent LFs contribute to dysfunctional wound repair process. Here, we investigated the influence of senescent LFs on alveolar epithelial cell repair responses in a co-culture system. Alveolar epithelial cell proliferation was attenuated when in co-culture with cells or conditioned media from, senescence-induced control LFs or IPF-LFs. Cell-cycle analyses showed that a larger number of epithelial cells were arrested in G2/M phase when co-cultured with IPF-LFs, than in monoculture. Paradoxically, the presence of LFs resulted in increased A549 migration after mechanical injury. Our data suggest that senescent LFs may contribute to aberrant re-epithelialization by inhibiting proliferation in IPF.

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