Primary Lesion FDG Uptake is Correlated with Clinical Stage for Adenocarcinoma but Not Squamous Cell Carcinoma in Lung Cancer Patients

2009 ◽  
Vol 75 (3) ◽  
pp. S536
Author(s):  
M. Li ◽  
Y. Sun ◽  
Y. Liu ◽  
A. Han ◽  
S. Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Clinical Stage ◽  
Primary Lesion ◽  
Lung Cancer Patients ◽  
Fdg Uptake

The Incidence and Outcome of Venous Thrombo-Embolism (VTE) In Non-Small Cell Lung Cancer Patients with Adenocarcinoma Histology In Comparison with Squamous Histology

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4221-4221 ◽  
Author(s):  
Ashwini Bhat ◽  
Rakesh Surapaneni ◽  
Alexandre Hageboutros ◽  
Barry Milcarek ◽  
Krystal Hunter ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients

Abstract Abstract 4221 Background: There have been only limited studies on the incidence and outcome of venous thrombosis in non-small cell lung cancer patients by histology. Patients with adenocarcinoma are believed to have the highest risk of developing venous thrombosis. Objectives: 1. To study the incidence and outcome of thrombosis in patients with non- small cell lung cancer. 2. To determine the differences in the venous thrombotic risk between adenocarcinoma and squamous cell carcinoma subtypes. Patients/Methods: we conducted a retrospective chart review analysis of all the non-small cell lung cancer patients diagnosed in 2008 and 2009 at our institution. Patient and tumor characteristics as well as all venous thrombotic events (VTE) in the course of the disease were recorded. Incidence rates of VTE were calculated as both cumulative incidence and as person-time events (events per 1000 patient years of follow-up). We counted person-years of follow-up for each subject from the date of initial lung cancer diagnosis until the date of a thrombotic event, the date of death, or the end of the study period (30 June 2010), whichever occurred first. Analysis of the difference between squamous cell carcinoma and adenocarcinoma histological subgroups was done using Cox proportional Hazards model. For survival and outcome analysis of patients who develop VTE after diagnosis of lung cancer, we again used a Cox proportional Hazards model with the thrombotic event as a time -dependent variable. Results: Among133 patients with non-small cell lung cancer, 86 had adenocarcinoma, 42 had squamous cell histology and 5 were large cell carcinomas (the latter were excluded from the analysis). The mean age of the patients was 66.2 years and their median survival was 377 days (1.04 years).We observed 25 events of VTE over 82.89 years of follow-up for an overall incidence of VTE of 301.6 per 1000 person-years. Among 86 patients with adenocarcinoma histology, we found 21 VTEs (24.4%) Among 42 patients with squamous cell carcinoma, 4 VTE s occurred (9.5 %). The incidence of VTE for patients with adenocarcinoma was 422 per 1000 person-years (95% CI: 282 – 568) and for patients with squamous cell carcinoma 125.97 per 1000 person-years (95 % CI: 36 – 298) resulting in a trend towards higher VTE incidence in patients with adenocarcinoma as compared to patients with squamous cell carcinoma. When the rate ratio between the adenocarcinoma (21/49.7) and squamous cell cancer (4/31.8) are compared, the rate ratio is 3.359 (1.207 – 9.352). The risk of developing a VTE was 2 fold increased for patients with adenocarcinoma vs. squamous cell carcinoma (crude hazard ratio 2.375 [95%CI: 0.664–8.491]) There was a trend towards lower survival time in patients who develop a VTE during the course of their disease compared to patients who did not develop a VTE. (HR 0.992, 95% CI:.449 – 2.193). 5 of the 21 patients in the adenocarcinoma group who had VTE had a second VTE despite anticoagulation. Discussion: Only few studies have described the absolute risk as incidence rates of VTE in lung cancer patients. One study in 2004 reported the incidence of VTE is 20-fold increased in lung cancer patients compared to general population; with 3-fold increase in patients with adenocarcinoma histology. Our study confirms the trend towards increased risk of VTE in adenocarcinoma histology, along with a worse outcome. Also, of interest, is the unusually high incidence of VTE noted in our study cohort compared to the reference studies (20.9% vs. 7.2%). This finding might be due to the enhanced awareness and high clinical suspicion leading to increased testing for VTE in the cancer patients. Based on these findings, prophylactic anticoagulation in these patients may be warranted to prevent development of venous thrombosis. This needs to be studied in a prospective clinical trial in the future. Disclosures: No relevant conflicts of interest to declare.

The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients

2019 ◽  
Vol 146 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Bing-Yen Wang ◽  
Jing-Yang Huang ◽  
Heng-Chung Chen ◽  
Ching-Hsiung Lin ◽  
Sheng-Hao Lin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Lung Cancer Patients

Abnormal Serum Hormone Levels in Lung Cancer

1983 ◽  
Vol 69 (4) ◽  
pp. 293-298 ◽  
Author(s):  
Camilla Recchione ◽  
Emanuele Galante ◽  
Giorgio Secreto ◽  
Adalberto Cavalleri ◽  
Veronica Dati
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lung Disease ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Lung Cancer Patients ◽  
Node Metastases

Serum levels of chorionic gonadotropin (HCG), testosterone, luteinizing hormone (LH) and prolactin were evaluated with the radioimmunoassay in 59 patients with lung cancer, 10 patients with benign lung disease, and 37 normal controls. HCG was present in 6.8% of the lung cancer patients but in none of the subjects of the other two groups. Prolactin and LH levels were significantly higher than normal in lung cancer patients (respectively p < 0.001 and p < 0.01) as well as in patients with benign lung disease (p < 0.01 for both the hormones). Testosterone levels were significantly lower than normal in patients with lung cancer (p < 0.05) but not in those with benign lung disease. When the patients were analyzed according to histologic type and clinical stage of disease, significantly lower than normal values of testosterone were found in patients with small cell carcinoma or squamous cell carcinoma. In the squamous cell carcinoma group, the patients with lymph node metastases had significantly lower testosterone levels than those without lymph node metastases. From these results, we may hypothesize that the raised levels of prolactin and LH are related to a pulmonary pathology, not necessarily neoplastic, whereas the low levels of testosterone are related to the presence of the tumor.

scholarly journals Tobacco Smoking and Trends in Histological Subtypes of Female Lung Cancer at The Cancer Hospital of The Chinese Academy of Medical Sciences Over 13 Years

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 29s-29s
Author(s):  
Q. Zeng ◽  
E. Vogtmann ◽  
M. Jia ◽  
M. Parascandola ◽  
Q. Feng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Lung Cancer Patients ◽  
Cancer Hospital ◽  
History Of ◽  
Female Lung Cancer ◽  
Histologic Subtypes

Background: Smoking among Chinese women accounts for a small proportion, but the incidence and mortality rates of female lung cancer is increasing in recent years. Studies found that there were changes in histologic subtypes of lung cancer patients in China. Aim: This study investigated the tobacco smoking and trends in histologic subtypes of female lung cancer in a cancer hospital in China. Methods: Demographic, smoking history and histologic information about female lung cancer patients diagnosed or treated from 2000 to 2012 was collected from Cancer Hospital, Chinese Academy of Medical Science (CHCAMS). Trends of histologic subtypes calculated with annual percentage change (APC). The distribution differences of adenocarcinoma (ADC), squamous cell carcinoma (SCC), small cell lung cancer (SCLC) and the other subtypes between smokers and nonsmokers were calculated by 7th AJCC cancer staging. Results: Totally of 5,870 female cases of lung cancer, including 630 with history of smoking and 5,240 without, were analyzed. The number of female lung cancer patients increased from 509 (2000-2002) to 1744 (2012-2013). The main histologic type of lung cancer was adenocarcinoma (ADC) (72.93%), followed by small cell lung cancer (SCLC) (11.06%), squamous cell carcinoma (SCC) (8.38%) and the other (7.63%). Among smokers, the proportion of SCC decreased from 40.5% to 23.7% (APC = -11.68%, P = 0.005), however, the ADC increased from 35.7% to 50.7% (APC = 8.63%, P = 0.009). In nonsmokers, the ADC was 76.1%, and SCC was 5.9%. ADC increased from 63.1% to 80.6% (APC = -21.33%, P = 0.006), SCC decreased from 13.6% to 4.5% (APC = 3.86%, P = 0.016). Among squamous cell carcinoma, the cases with history of smoking were more likely diagnosed at early stages (I/II: 47.1%) than those at late stages (III, 34.3%; IV, 18.6%). Conclusion: The number of female lung cancer patients was increased in CHCAMS by year of diagnosis. In both smoking and nonsmoking cases, the proportion of adenocarcinoma was increasing. Among the squamous cell carcinoma, smokers seem to find in early stages.

scholarly journals Coexistence of lung squamous cell carcinoma and pulmonary tuberculosis within a single lesion: a case report

2020 ◽  
Author(s):  
Guoliang Xiao ◽  
Shengjie Chen
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Pulmonary Tuberculosis ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Left Lung ◽  
Lung Squamous Cell Carcinoma ◽  
Active Pulmonary Tuberculosis ◽  
Lung Cancer Patients

Abstract Background: Tuberculosis and lung cancer are common high-mortality lung diseases, but it is rare that lung cancer and tuberculosis exist in the same lesion. In addition, lung cancer with pulmonary tuberculosis is similar in morphology to lung cancer without tuberculosis. For these reasons, lung cancer patients with tuberculosis are often misdiagnosed and mistreated, so these patients have a poorer prognosis than lung cancer patients without tuberculosis. Therefore, a full understanding of such cases can help early diagnosis, so that appropriate treatments can be performed timely. Case presentations: A 52-year-old male. The physical examination revealed a cavity-like nodule in the upper left lung and the first diagnosis was tuberculosis. There was no significant change in lung nodules after anti-tuberculosis treatment. So the patient was admitted to the hospital for surgical treatment of lung cancer. Postoperative pathological showed that the lesion was lung squamous cell carcinoma with tuberculosis.Conclusion: the survival rate of patients with active pulmonary tuberculosis and lung cancer is lower than those with lung cancer or tuberculosis alone. Which is mainly due to incomplete diagnosis. if we find hollow shadows in the lungs on CT, we should think about the possibility of coexistence of lung cancer and tuberculosis, and then the appropriate treatment and management strategies should be developed.

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