Preoperative Dose Painting IMRT Chemoradiation to 56 Gy in Esophageal Cancer Doubles Pathologic Complete Response Rate Without Increasing Toxicity

2012 ◽  
Vol 84 (3) ◽  
pp. S42 ◽  
Author(s):  
R. Shridhar ◽  
M.D. Chuong ◽  
J. Weber ◽  
K. Almhanna ◽  
K.L. Meredith ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Response Rate ◽  
Complete Response Rate ◽  
Pathologic Complete Response ◽  
Complete Response ◽  
Dose Painting ◽  
Pathologic Complete Response Rate

scholarly journals Triple negative breast cancer subtypes and pathologic complete response rate to neoadjuvant chemotherapy

Oncotarget ◽  
2018 ◽  
Vol 9 (41) ◽  
pp. 26406-26416 ◽  
Author(s):  
Angela Santonja ◽  
Alfonso Sánchez-Muñoz ◽  
Ana Lluch ◽  
Maria Rosario Chica-Parrado ◽  
Joan Albanell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Response Rate ◽  
Complete Response Rate ◽  
Pathologic Complete Response ◽  
Complete Response ◽  
Cancer Subtypes ◽  
Pathologic Complete Response Rate

Modeling precision genomic-based radiation dose response in rectal cancer

2020 ◽  
Vol 16 (30) ◽  
pp. 2411-2420
Author(s):  
Zhigang Yuan ◽  
Marissa Frazer ◽  
Kamran A Ahmed ◽  
Syeda Mahrukh Hussnain Naqvi ◽  
Michael J Schell ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Dose ◽  
Dose Response ◽  
Response Rate ◽  
Complete Response Rate ◽  
Prospective Trial ◽  
Pathologic Complete Response ◽  
Complete Response ◽  
Bimodal Distribution ◽  
Pathologic Complete Response Rate

Aim: Genomic-based risk stratification to personalize radiation dose in rectal cancer. Patients & methods: We modeled genomic-based radiation dose response using the previously validated radiosensitivity index (RSI) and the clinically actionable genomic-adjusted radiation dose. Results: RSI of rectal cancer ranged from 0.19 to 0.81 in a bimodal distribution. A pathologic complete response rate of 21% was achieved in tumors with an RSI <0.31 at a minimal genomic-adjusted radiation dose of 29.76 when modeling RxRSI to the commonly prescribed physical dose of 50 Gy. RxRSI-based dose escalation to 55 Gy in tumors with an RSI of 0.31–0.34 could increase pathologic complete response by 10%. Conclusion: This study provides a theoretical platform for development of an RxRSI-based prospective trial in rectal cancer.

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