(S002) Population-Based Analysis of the Effect of Margin Status on 10-Year Local Recurrence and Breast Cancer-Specific Survival in Women Treated With Breast-Conserving Therapy

e13034 Background: Patients successfully treated for hormone receptor (HR)-positive early breast cancer remain at risk of recurrence and metastatic disease even after extended periods of disease-free years. Whether prolonged metastatic-free intervals ultimately confer a benefit to breast cancer-specific survival is not well understood. This study aimed to investigate metastatic-free intervals and risk of breast cancer-specific mortality among patients with HR-positive breast cancer after adjuvant therapy. Methods: We conducted a retrospective cohort study of women aged 18 years and older diagnosed with recurrent metastatic HR-positive breast cancer between 1990 and 2016 in the Surveillance, Epidemiology, and End Results registries. Patients with longitudinal information on primary stage I-III HR-positive breast cancer through the occurrence of metastatic disease and survival were included. Risks of breast cancer-specific mortality associated with metastatic-free intervals (defined as time from primary breast cancer diagnosis to metastasis) of ≥5 years compared to < 5 years were estimated. Fine and Gray competing risks regression models were used to calculate subdistribution hazard ratios (SHR) and 95% confidence intervals (CI). Results: Among 1,057 women with HR-positive breast cancer with a median age of 54 years at primary breast cancer diagnosis and 62 years at metastatic progression, 65% of women had a metastatic-free disease interval ≥5 years, whereas 35% had an interval of < 5 years. Overall, patients with metastatic-free intervals < 5 years had a five-year breast cancer-specific survival rate of 31% compared to 52% in women with intervals of ≥5 years. In multivariable analyses adjusted for age, race, diagnosis year, grade, treatment and sites of metastasis, patients with intervals of ≥5 years had decreased risk of breast cancer-specific mortality (SHR = 0.72, 95% CI 0.58-0.89, P = 0.002) compared to women with metastatic-free intervals of < 5 years. Conclusions: In this population-based study, rates of cancer-specific mortality among patients who experienced metastatic recurrence of HR-positive breast cancer were lower in women with metastatic-free intervals of 5 years or more. The results of this study may inform patient-clinician discussions surrounding prognosis and treatment selection among HR-positive patients.

Download Full-text

Margin Status and the Risk of Local Recurrence (LR) in Patients With Early-Stage Breast Cancer Treated With Breast-Conserving Therapy (BCT)

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2013.06.029 ◽

2013 ◽

Vol 87 (2) ◽

pp. S8-S9

Author(s):

A.L. Russo ◽

A. Niemierko ◽

N.L. Wong ◽

N. Arvold ◽

J. Wong ◽

...

Keyword(s):

Breast Cancer ◽

Local Recurrence ◽

Early Stage ◽

Breast Conserving Therapy ◽

Margin Status ◽

Early Stage Breast Cancer

Download Full-text

A Population-Based Study of Breast Cancer-Specific Survival Following Mastectomy and Immediate or Early-Delayed Breast Reconstruction

Breast Diseases A Year Book Quarterly ◽

10.1016/j.breastdis.2013.01.044 ◽

2013 ◽

Vol 24 (1) ◽

pp. 85-86

Author(s):

D.M. Adelman ◽

C.E. Butler

Keyword(s):

Breast Cancer ◽

Breast Reconstruction ◽

Population Based ◽

Breast Cancer Specific Survival ◽

Cancer Specific Survival ◽

Population Based Study ◽

Delayed Breast Reconstruction

Download Full-text

Effects of Surgery on Prognosis of Young Women With Operable Breast Cancer in Different Marital Statuses: A Population-Based Cohort Study

Frontiers in Oncology ◽

10.3389/fonc.2021.666316 ◽

2021 ◽

Vol 11 ◽

Author(s):

Junsheng Zhang ◽

Ciqiu Yang ◽

Yi Zhang ◽

Fei Ji ◽

Hongfei Gao ◽

...

Keyword(s):

Breast Cancer ◽

Young Women ◽

Survival Benefit ◽

Breast Conserving Therapy ◽

Population Based ◽

Operable Breast Cancer ◽

Surgical Approaches ◽

Cancer Specific Survival ◽

Significant Difference ◽

Cox Proportional Hazard Regression

BackgroundThe influence of surgical approaches [including mastectomy, breast-conserving therapy (BCT) and post-mastectomy breast reconstruction (PMBR) on prognosis of young women (<40 years old) with operable breast cancer has not been determined yet, and this might vary in patients with different marital statuses. Therefore, we aimed to investigate the effect of surgery on survival outcomes for young women with operable breast cancer in different marital statuses.MethodsWe used the Surveillance, Epidemiology, and End Results (SEER) database to identify young women with operable breast cancer between 2004 and 2016, who underwent mastectomy, BCT or PMBR. We assessed overall survival (OS) and breast cancer-specific survival (BCSS) using the Kaplan–Meier method and hazard ratios using multivariate Cox proportional hazard regression.ResultsCompared to mastectomy, both of BCT and PMBR conferred better OS (BCT: HR = 0.79, 95%CI: 0.69–0.90, p <0.001; PMBR: HR = 0.70, 95%CI: 0.63–0.78, p <0.001) and BCSS (BCT: HR = 0.79, 95%CI: 0.69–0.91, p = 0.001; PMBR: HR = 0.73, 95%CI: 0.65–0.81, p <0.001), but there was no significant difference of survival between BCT and PMBR group. The survival benefit of BCT compared to mastectomy remained significant in unmarried young women (OS: HR = 0.68, 95%CI: 0.55–0.83, p <0.001; BCSS: HR = 0.69, 95%CI: 0.56–0.86, p = 0.001) but not in the married (OS: HR = 0.89, 95%CI: 0.75–1.05, p = 0.177; BCSS: HR = 0.89, 95%CI: 0.75–1.05, p = 0.161), while no matter married or not, PMBR group had better OS and BCSS than mastectomy group but not BCT group.ConclusionBoth of BCT and PMBR had improved survival compared to mastectomy for young women with operable breast cancer. The survival benefit of BCT compared to mastectomy remained significant in unmarried patients but not in married patients.

Download Full-text