scholarly journals Long-Term Outcomes of Three-Dimensional Conformal Radiation Therapy Without Chemotherapy for Esophageal Squamous Cell Carcinoma: A Final Report of a Phase 2 Study

2017 ◽  
Vol 99 (2) ◽  
pp. S191
Author(s):  
X. Fan ◽  
H. Wang ◽  
K. Wu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Esophageal Squamous Cell Carcinoma ◽  
Three Dimensional ◽  
Final Report ◽  
Phase 2 ◽  
Long Term Outcomes ◽  
Conformal Radiation Therapy ◽  
Phase 2 Study

scholarly journals Induction Chemotherapy Plus Simultaneous Modulated Accelerated Radiation Therapy in Non-operative Hypopharyngeal and Supraglottic Laryngeal Squamous Cell Carcinoma: Long-Term Outcome of a Prospective Phase 2 Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Boning Cai ◽  
Lingling Meng ◽  
Jingzi Mo ◽  
Shouping Xu ◽  
Baolin Qu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Phase 2 ◽  
Long Term Outcomes ◽  
Phase 2 Study ◽  
Prospective Phase ◽  
Accelerated Radiation Therapy

Background: To evaluate the toxicities and long-term outcomes of induction chemotherapy (ICT) plus simultaneous modulated accelerated radiation therapy (SMART) in non-operative hypopharyngeal and supraglottic laryngeal squamous cell carcinoma (SCCH/L).Materials and Methods: This was a prospective phase 2 study. Patients diagnosed with SCCH/L, aged from 18 to 75, staged from III to IVB in accordance with the AJCC 2010 criteria, and refusing surgery were eligible. The patients were treated with 2–3 cycles of docetaxel-cisplatin-based ICT and SMART combined with 2–3 cycles of cisplatin-based concurrent chemotherapy. The prescription dose to the primary tumor and metastatic nodes was 69 Gy in 30 fractions. Acute and late toxicities were assessed according to the established Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria, and long-term outcomes were analyzed.Results: Between February 2013 and June 2015, 55 newly diagnosed SCCH/L patients were enrolled. No grade 2 or worse acute xerostomia was noted. The incidences of grade 3 acute dermatitis, oral mucositis, and pharyngoesophagitis were 12.7, 3.6, and 12.7%, respectively. The median follow-up time was 48 months (range 5.5–74 months). The main late toxicity was hoarseness or sore throat, with an incidence of 32.7%. The 5-year functional larynx-preservation survival was 51.5%. The 3- and 5-year locoregional control and overall survival were 58.2, 51.5, 63.6, and 54.1%, respectively.Conclusions: The ICT plus SMART with a regimen of 69 Gy/30 F for the treatment of SCCH/L demonstrated acceptable severe toxicity, satisfactory long-term outcomes, and laryngeal function preservation.

scholarly journals Three‐dimensional conformal radiation therapy alone for esophageal squamous cell carcinoma: 10‐year survival outcomes

2019 ◽  
Vol 10 (3) ◽  
pp. 519-525 ◽  
Author(s):  
Xing‐Wen Fan ◽  
Jun‐Lan Wu ◽  
Hong‐Bing Wang ◽  
Fei Liang ◽  
Guo‐Liang Jiang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Three Dimensional ◽  
Survival Outcomes ◽  
Conformal Radiation Therapy

scholarly journals Efficacy and Safety of Limited-Margin Conformal Radiation Therapy for Pediatric Rhabdomyosarcoma: Long-Term Results of a Phase 2 Study

2020 ◽  
Vol 107 (1) ◽  
pp. 172-180
Author(s):  
Christopher L. Tinkle ◽  
Alberto Pappo ◽  
Jianrong Wu ◽  
Shenghua Mao ◽  
Chia-ho Hua ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Long Term Results ◽  
Phase 2 ◽  
Efficacy And Safety ◽  
Conformal Radiation Therapy ◽  
Phase 2 Study

Long-term outcomes of three-dimensional conformal radiation therapy combined with neoadjuvant hormonal therapy for Japanese patients with T1c-T2N0M0 prostate cancer

2011 ◽  
Vol 17 (6) ◽  
pp. 562-568 ◽  
Author(s):  
Takashi Mizowaki ◽  
Kenji Takayama ◽  
Yoshiki Norihisa ◽  
Masakazu Ogura ◽  
Tomomi Kamba ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Hormonal Therapy ◽  
Three Dimensional ◽  
Japanese Patients ◽  
Long Term Outcomes ◽  
Conformal Radiation Therapy ◽  
Neoadjuvant Hormonal Therapy
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