MC1675, a Phase III Evaluation of De-Escalated Adjuvant Radiation Therapy (DART) vs. Standard Adjuvant Treatment for Human Papillomavirus Associated Oropharyngeal Squamous Cell Carcinoma

2021 ◽  
Vol 111 (5) ◽  
pp. 1324
Author(s):  
D.M. Ma ◽  
K. Price ◽  
E.J. Moore ◽  
S.H. Patel ◽  
M.L. Hinni ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adjuvant Treatment ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Phase Iii ◽  
Adjuvant Radiation ◽  
Adjuvant Radiation Therapy

Surgically Treated Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck: Outcome Predictors and the Role of Adjuvant Radiation Therapy

2021 ◽  
pp. 000348942199018
Author(s):  
Liyona Kampel ◽  
Alexandra Dorman ◽  
Gilad Horowitz ◽  
Dan M. Fliss ◽  
Orit Gutfeld ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Treatment Outcomes ◽  
Squamous Cell ◽  
Disease Free Survival ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Adjuvant Radiation ◽  
Adjuvant Radiation Therapy

Objectives: Advanced cutaneous squamous cell carcinoma of the head and neck (CSCCHN) is associated with poor outcome despite multimodality therapy. Comprehensive risk stratification may pinpoint the most suitable adjuvant treatment. This study aimed to evaluate the outcomes of surgically treated locoregional CSCCHN and to identify prognostic indicators of treatment outcomes. Methods: We retrospectively analyzed disease variables, pathologic characteristics, and management in association with treatment outcomes of all consecutive advanced CSCCHN patients who underwent surgical resection at Tel Aviv Sourasky Medical Center. Results: From 2008 to 2018, 74 patients met the inclusion criteria. Only perineural invasion (PNI) was significantly associated with worse overall survival (OS) ( P = .001). Location within the facial “mask areas” was significantly associated with pathologically negative cervical disease ( P = .001). Forty-seven patients underwent adjuvant radiation therapy (RT) which significantly improved OS and disease-free survival versus surgery alone ( P = .025 and P = 0.035, respectively). Conclusion: PNI was associated with worse OS in surgically treated advanced CSCCHN. Adjuvant RT conferred better outcomes despite high risk features.

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