Optimizing conditions for oleanolic acid extraction from Lantana camara roots using response surface methodology

The instantaneous controlled pressure drop process (or D.I.C process: ``Détente Instantanée Contrôlée") was used as a pre-treatment prior to pectin acid extraction from orange peel. This process involves subjecting the orange peel for a short time to steam pressure varying from 100 to 700 kPa, followed by an instantaneous decompression to vacuum at 5 kPa. Effects of processing pressure, moisture content of peels before the thermomechanical treatment and processing time were examined with response surface methodology. The optimal conditions were determined and the response surfaces were plotted from the mathematical models. The Fisher test and p-value indicated that both processing pressure and moisture content of peels before the pre-treatment had a highly significant effect on the pectin yield. The quadratic effect of processing pressure as well as the interaction effects of the initial moisture content and processing time also had a significant effect on the response. Moreover, the kinetics of pectin extraction showed that after few minutes of hydrolysis, the yields of pectin were systematically higher than that of the control sample and this is important from industrial point of view because the hydrolysis of pectin is generally performed in 10-15 minutes.

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OPTIMIZATION OF PROPIONIC ACID EXTRACTION BY AQUEOUS TWO-PHASE SYSTEM USING RESPONSE SURFACE METHODOLOGY

Chemical Engineering Communications ◽

10.1080/00986445.2012.721032 ◽

2013 ◽

Vol 200 (5) ◽

pp. 667-677 ◽

Cited By ~ 18

Author(s):

Gholam Khayati

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Propionic Acid ◽

Phase System ◽

Acid Extraction ◽

Two Phase ◽

Aqueous Two Phase System

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Optimization of Chlorogenic Acid Extraction from Green Coffee Beans Using Response Surface Methodology

Vietnam Journal of Agricultural Sciences ◽

10.31817/vjas.2019.2.1.04 ◽

2019 ◽

Vol 2 (1) ◽

pp. 332-342

Author(s):

Ha Thi Ngoc Lai ◽

Phuong Viet Nguyen ◽

Hoai Thi Tran ◽

Viet Ha Thi Dao ◽

Ha Hai Hoang

Keyword(s):

Response Surface Methodology ◽

Chlorogenic Acid ◽

Response Surface ◽

Biological Properties ◽

Acid Extraction ◽

Green Coffee ◽

Solid Ratio ◽

Green Coffee Beans ◽

Coffee Beans ◽

Experimental Values

Chlorogenic acid is a natural antioxidant that is widespread in the plant kingdom and can be found at a high content level in green coffee beans. This secondary metabolite in green coffee beans has potent biological properties including antioxidant, anti-inflammatory, anti-cancer, anti-obesity, anti-hypertension, and anticonvulsant. In this study, the extraction of chlorogenic acid from Vietnamese green coffee beans was optimized using the response surface methodology. A second-order polynomial model with three important variables (liquid-to-solid ratio, temperature, and extraction time) was used. A rotatable central composite design consisting of 21 experimental runs with three replicates at the center point was applied to describe the experimental data. The experimental results properly conformed to the constructed model (R2 = 0.8549). The optimized conditions were as follows: 40% ethanol (v/v), a liquid-to-solid ratio of 11.77, at 85oC for 64 min. Four extractions were performed in parallel using the optimal conditions to validate the model. The experimental values highly agreed with the predicted value (P <0.05).

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Optimisation of pectin acid extraction from passion fruit peel (Passiflora edulisflavicarpa) using response surface methodology

International Journal of Food Science & Technology ◽

10.1111/j.1365-2621.2008.01753.x ◽

2009 ◽

Vol 44 (3) ◽

pp. 476-483 ◽

Cited By ~ 73

Author(s):

Erika Kliemann ◽

Karina Nunes de Simas ◽

Edna R. Amante ◽

Elane Schwinden Prudêncio ◽

Reinaldo F. Teófilo ◽

...

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Passion Fruit ◽

Acid Extraction ◽

Fruit Peel

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Reactive extraction of propionic acid using trioctylamine in 1–decanol by response surface methodology optimization technique

International Journal of Low-Carbon Technologies ◽

10.1093/ijlct/ctz069 ◽

2020 ◽

Vol 15 (2) ◽

pp. 171-179 ◽

Cited By ~ 2

Author(s):

Victoria M Inyang ◽

David Lokhat

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Propionic Acid ◽

Acid Concentration ◽

Optimization Technique ◽

Statistical Design ◽

Reactive Extraction ◽

Acid Extraction ◽

Process Variables ◽

Optimum Conditions

Abstract Reactive extraction, a novel technique, was experimentally investigated for the removal of propionic acid, which is usually present in low concentrations in aqueous solutions. The experiments were conducted according to statistical design to develop an appropriate regression model. This was aimed at analyzing and optimizing the process variables and extraction efficiency for propionic acid reactive extraction from dilute aqueous streams using trioctylamine as extractant and 1-decanol as organic diluent. Response surface methodology in combination with Box–Behnken design involving 17 experimental runs was utilized for the propionic acid reactive extraction in this study. Three independent process variables were chosen as temperature (T), initial propionic acid concentration (CPAO) in the aqueous phase and trioctylamine composition (CTOA) in the organic phase. The statistical design analysis demonstrated that the propionic acid concentration and TOA composition had a significant effect while temperature had an insignificant effect on the response value as well as an interactive and quadratic effect on the response. The optimum conditions for propionic acid extraction were established as T = 300.752 K, CTOA = 18.252 %v/v, CPAO = 0.408 kmol/m3. Under these optimum conditions, the propionic acid experimental extraction yield was 89.788 %, which was in close conformity with the predicted yield value of 91.939 %.

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