Comparative effect of two pan-class I PI3K inhibitors used as anticancer drugs on human T cell function

2015 ◽  
Vol 28 (1) ◽  
pp. 675-685 ◽  
Author(s):  
Belén Blanco ◽  
Carmen Herrero-Sánchez ◽  
Concepción Rodríguez-Serrano ◽  
Mercedes Sánchez-Barba ◽  
María Consuelo del Cañizo
Keyword(s):  
T Cell ◽  
Anticancer Drugs ◽  
Cell Function ◽  
Class I ◽  
Comparative Effect ◽  
Pi3k Inhibitors ◽  
T Cell Function ◽  
Human T Cell

Soluble MHC class I Molecules abrogate T Cell Function

1998 ◽  
Vol 65 (Supplement) ◽  
pp. 97
Author(s):  
N. Zavazava ◽  
M. Krönke
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
Cell Function ◽  
Class I ◽  
T Cell Function ◽  
Mhc Class I Molecules

Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population

10.1038/72323 ◽  
2000 ◽  
Vol 6 (2) ◽  
pp. 211-214 ◽  
Author(s):  
David E. Anderson ◽  
Katarzyna D. Bieganowska ◽  
Amit Bar-Or ◽  
Enedina M.L. Oliveira ◽  
Beatriz Carreno ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Population ◽  
Cell Function ◽  
T Cell Function ◽  
Human T Cell

O.058 Impact of human hepatocyte MHC-class I antigen presentation on virus-specific CD8 T cell function

2006 ◽  
Vol 36 ◽  
pp. S17-S18
Author(s):  
A.J. Gehring ◽  
P.T.F. Kennedy ◽  
D. Sun ◽  
E. Nolte-'t Hoen ◽  
S. Lim ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Presentation ◽  
Mhc Class I ◽  
Cell Function ◽  
Cd8 T Cell ◽  
Human Hepatocyte ◽  
Class I ◽  
T Cell Function ◽  
Mhc Class I Antigen

scholarly journals ALTERATION OF HUMAN T-CELL FUNCTION AFTER THYMIC IRRADIATION

1974 ◽  
Vol 8 (4) ◽  
pp. 418-418
Author(s):  
Christian H L Rieger ◽  
Simmer C Kraft ◽  
Richard M Rothberg
Keyword(s):  
T Cell ◽  
Cell Function ◽  
T Cell Function ◽  
Human T Cell

scholarly journals Human ILT2 receptor associates with murine MHC class I moleculesin vivo and impairs T cell function

2006 ◽  
Vol 36 (9) ◽  
pp. 2457-2471 ◽  
Author(s):  
Siyuan Liang ◽  
Wei Zhang ◽  
Anatolij Horuzsko
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
Cell Function ◽  
Class I ◽  
T Cell Function

scholarly journals Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases

PLoS Biology ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. e3001063
Author(s):  
Anand Sripada ◽  
Kapil Sirohi ◽  
Lidia Michalec ◽  
Lei Guo ◽  
Jerome T. McKay ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Function ◽  
Airway Hyperreactivity ◽  
Mouse Strains ◽  
Caveolin 1 ◽  
T Cell Function ◽  
Human T Cell ◽  
Extracellular Signal

The function of Sprouty2 (Spry2) in T cells is unknown. Using 2 different (inducible and T cell–targeted) knockout mouse strains, we found that Spry2 positively regulated extracellular signal-regulated kinase 1/2 (ERK1/2) signaling by modulating the activity of LCK. Spry2−/− CD4+ T cells were unable to activate LCK, proliferate, differentiate into T helper cells, or produce cytokines. Spry2 deficiency abrogated type 2 inflammation and airway hyperreactivity in a murine model of asthma. Spry2 expression was higher in blood and airway CD4+ T cells from patients with asthma, and Spry2 knockdown impaired human T cell proliferation and cytokine production. Spry2 deficiency up-regulated the lipid raft protein caveolin-1, enhanced its interaction with CSK, and increased CSK interaction with LCK, culminating in augmented inhibitory phosphorylation of LCK. Knockdown of CSK or dislodgment of caveolin-1–bound CSK restored ERK1/2 activation in Spry2−/− T cells, suggesting an essential role for Spry2 in LCK activation and T cell function.

Human T-cell function in experimental ascorbic acid deficiency and spontaneous scurvy

1982 ◽  
Vol 36 (1) ◽  
pp. 127-130 ◽  
Author(s):  
N E Kay ◽  
D E Holloway ◽  
S W Hutton ◽  
N D Bone ◽  
W C Duane
Keyword(s):  
Ascorbic Acid ◽  
T Cell ◽  
Cell Function ◽  
Ascorbic Acid Deficiency ◽  
T Cell Function ◽  
Human T Cell ◽  
Acid Deficiency

scholarly journals Large-Scale Prospective T Cell Function Assays in Shipped, Unfrozen Blood Samples: Experiences from the Multicenter TRIGR Trial

2013 ◽  
Vol 21 (2) ◽  
pp. 203-211 ◽  
Author(s):  
David Hadley ◽  
Roy K. Cheung ◽  
Dorothy J. Becker ◽  
Rose Girgis ◽  
Jerry P. Palmer ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Dependent Diabetes Mellitus ◽  
Biochemical Tests ◽  
Blood Draw ◽  
Blood Samples ◽  
Cell Functions ◽  
Cell Counts ◽  
T Cell Function ◽  
Human T Cell

ABSTRACTBroad consensus assigns T lymphocytes fundamental roles in inflammatory, infectious, and autoimmune diseases. However, clinical investigations have lacked fully characterized and validated procedures, equivalent to those of widely practiced biochemical tests with established clinical roles, for measuring core T cell functions. The Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR) type 1 diabetes prevention trial used consecutive measurements of T cell proliferative responses in prospectively collected fresh heparinized blood samples shipped by courier within North America. In this article, we report on the quality control implications of this simple and pragmatic shipping practice and the interpretation of positive- and negative-control analytes in our assay. We used polyclonal and postvaccination responses in 4,919 samples to analyze the development of T cell immunocompetence. We have found that the vast majority of the samples were viable up to 3 days from the blood draw, yet meaningful responses were found in a proportion of those with longer travel times. Furthermore, the shipping time of uncooled samples significantly decreased both the viabilities of the samples and the unstimulated cell counts in the viable samples. Also, subject age was significantly associated with the number of unstimulated cells and T cell proliferation to positive activators. Finally, we observed a pattern of statistically significant increases in T cell responses to tetanus toxin around the timing of infant vaccinations. This assay platform and shipping protocol satisfy the criteria for robust and reproducible long-term measurements of human T cell function, comparable to those of established blood biochemical tests. We present a stable technology for prospective disease-relevant T cell analysis in immunological diseases, vaccination medicine, and measurement of herd immunity.

scholarly journals Regulation of MHC Class I Expression by Foxp3 and Its Effect on Regulatory T Cell Function

2014 ◽  
Vol 192 (6) ◽  
pp. 2892-2903 ◽  
Author(s):  
Jie Mu ◽  
Xuguang Tai ◽  
Shankar S. Iyer ◽  
Jocelyn D. Weissman ◽  
Alfred Singer ◽  
...  
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Class I ◽  
T Cell Function
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