Cathepsin L regulates pathogenic CD4 T cells in experimental autoimmune encephalomyelitis

2021 ◽  
Vol 93 ◽  
pp. 107425
Author(s):  
Miho Shibamura-Fujiogi ◽  
Koichi Yuki ◽  
Lifei Hou
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Cd4 T Cells ◽  
Cathepsin L ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals The Disease-Ameliorating Function of Autoregulatory CD8 T Cells Is Mediated by Targeting of Encephalitogenic CD4 T Cells in Experimental Autoimmune Encephalomyelitis

2013 ◽  
Vol 191 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Sterling B. Ortega ◽  
Venkatesh P. Kashi ◽  
Andrew F. Tyler ◽  
Khrishen Cunnusamy ◽  
Jason P. Mendoza ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis

2016 ◽  
Vol 291 ◽  
pp. 39-45 ◽  
Author(s):  
Koji Shinoda ◽  
Xun Sun ◽  
Akiko Oyamada ◽  
Hisakata Yamada ◽  
Jun-ichi Kira ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Cd4 T Cells ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Analysis of Autoreactive CD4 T Cells in Experimental Autoimmune Encephalomyelitis after Primary and Secondary Challenge Using MHC Class II Tetramers

2004 ◽  
Vol 172 (5) ◽  
pp. 2878-2884 ◽  
Author(s):  
Felix Bischof ◽  
Matthias Hofmann ◽  
Ton N. M. Schumacher ◽  
Florry A. Vyth-Dreese ◽  
Robert Weissert ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Mhc Class Ii ◽  
Cd4 T Cells ◽  
Class Ii ◽  
Autoimmune Encephalomyelitis ◽  
Secondary Challenge ◽  
Experimental Autoimmune

scholarly journals The Contribution of Immune and Glial Cell Types in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Samuel S. Duffy ◽  
Justin G. Lees ◽  
Gila Moalem-Taylor
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Glial Cell ◽  
Cd4 T Cells ◽  
Killer Cell ◽  
Cell Subset ◽  
Cell Types ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterised by widespread areas of focal demyelination. Its aetiology and pathogenesis remain unclear despite substantial insights gained through studies of animal models, most notably experimental autoimmune encephalomyelitis (EAE). MS is widely believed to be immune-mediated and pathologically attributable to myelin-specific autoreactive CD4+ T cells. In recent years, MS research has expanded beyond its focus on CD4+ T cells to recognise the contributions of multiple immune and glial cell types to the development, progression, and amelioration of the disease. This review summarises evidence of T and B lymphocyte, natural killer cell, macrophage/microglial, astrocytic, and oligodendroglial involvement in both EAE and MS and the intercommunication and influence of each cell subset in the inflammatory process. Despite important advances in the understanding of the involvement of these cell types in MS, many questions still remain regarding the various subsets within each cell population and their exact contribution to different stages of the disease.

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