Impaired airway epithelial barrier integrity was mediated by PI3Kδ in a mouse model of lipopolysaccharide-induced acute lung injury

2021 ◽  
Vol 95 ◽  
pp. 107570
Author(s):  
Lihong Yao ◽  
Ying Tang ◽  
Junjie Chen ◽  
Jiahui Li ◽  
Hua Wang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Mouse Model ◽  
Epithelial Barrier ◽  
Airway Epithelial ◽  
Barrier Integrity

scholarly journals Tissue Factor Enhances the Alveolar Epithelial Barrier Integrity during Acute Lung Injury

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Holly Sucharski ◽  
Nathan Putz ◽  
Ciara Shaver ◽  
Lorraine Ware ◽  
Julie Bastarache
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tissue Factor ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
Alveolar Epithelial

scholarly journals Regulators of endothelial and epithelial barrier integrity and function in acute lung injury

2009 ◽  
Vol 77 (12) ◽  
pp. 1763-1772 ◽  
Author(s):  
Rudolf Lucas ◽  
Alexander D. Verin ◽  
Stephen M. Black ◽  
John D. Catravas
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
And Function

scholarly journals miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin

2018 ◽  
Vol 233 (9) ◽  
pp. 6615-6631 ◽  
Author(s):  
Wang Xie ◽  
Qingchun Lu ◽  
Kailing Wang ◽  
Jingjing Lu ◽  
Xia Gu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Mouse Model ◽  
Lung Inflammation

scholarly journals Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury

2009 ◽  
Vol 297 (2) ◽  
pp. L219-L227 ◽  
Author(s):  
Charlie Wray ◽  
Ying Mao ◽  
Jue Pan ◽  
Anita Chandrasena ◽  
Frank Piasta ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tight Junction ◽  
Pulmonary Edema ◽  
Barrier Function ◽  
Mapk Pathway ◽  
Paracellular Transport ◽  
Epithelial Barrier ◽  
Altered Expression ◽  
Alveolar Epithelial

Intact alveolar barrier function is associated with better outcomes in acute lung injury patients; however, the regulation of alveolar epithelial paracellular transport during lung injury has not been extensively investigated. This study was undertaken to determine whether changes in tight junction claudin expression affect alveolar epithelial barrier properties and to determine the mechanisms of altered expression. In anesthetized mice exposed to ventilator-induced lung injury, claudin-4 was specifically induced among tight junction structural proteins. Real-time PCR showed an eightfold increase in claudin-4 expression in the lung injury model. To examine the role of this protein in barrier regulation, claudin-4 function was inhibited with small interfering RNA (siRNA) and a blocking peptide derived from the binding domain of Clostridium perfringens enterotoxin (CPEBD). Inhibition of claudin-4 decreased transepithelial electrical resistance but did not alter macromolecule permeability in primary rat and human epithelial cells. In mice, CPEBD decreased air space fluid clearance >33% and resulted in pulmonary edema during moderate tidal volume ventilation that did not induce edema in control peptide-treated mice. In vitro phorbol ester induced a ninefold increase in claudin-4 expression that was dependent on PKC activation and the JNK MAPK pathway. These data establish that changes in alveolar epithelial claudin expression influence paracellular transport, alveolar fluid clearance rates, and susceptibility to pulmonary edema. We hypothesize that increased claudin-4 expression early in acute lung injury represents a mechanism to limit pulmonary edema and that the regulation of alveolar epithelial claudin expression may be a novel target for acute lung injury therapy.

Glucocorticoids Enhance Airway Epithelial Barrier Integrity

2011 ◽  
Author(s):  
Akiko Sekiyama ◽  
Yasuhiro Gon ◽  
Masahiro Terakado ◽  
Ikuko Takeshita ◽  
Yutaka Kozu ◽  
...  
Keyword(s):  
Epithelial Barrier ◽  
Airway Epithelial ◽  
Barrier Integrity

scholarly journals Hydrostatin-SN1, a Sea Snake-Derived Bioactive Peptide, Reduces Inflammation in a Mouse Model of Acute Lung Injury

2017 ◽  
Vol 8 ◽  
Author(s):  
Guosheng Wu ◽  
Junjie Wang ◽  
Pengfei Luo ◽  
An Li ◽  
Song Tian ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Mouse Model ◽  
Bioactive Peptide ◽  
Sea Snake
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