A fixed-time sliding mode control (FTSMC) method is proposed for a second-order system with mismatched uncertainties in this paper. A new sliding mode, which is insensitive to the mismatched disturbance, is present to eliminate the effect of mismatched uncertainties by adopting the differentiable nonlinear function, and to obtain the fixed time stability independent of initial conditions by using the fraction-order function. In order to improve the performance of control system, the extended disturbance-observer-based fixed-time sliding mode control (EDO-FTSMC) approach is investigated to obtain the fixed-time stability subject to the mismatched uncertainties. Finally, the performance of the proposed control method is illustrated to compare other control approaches with numerical simulation results and application examples.