scholarly journals Predicting Lupus Membranous Nephritis using Reduced Picolinic Acid to Tryptophan Ratio as a Urinary Biomarker

iScience ◽  
2021 ◽  
pp. 103355
Author(s):  
Krittima Anekthanakul ◽  
Siriphan Manocheewa ◽  
Kittiphan Chienwichai ◽  
Patcha Poungsombat ◽  
Suphitcha Limjiasahapong ◽  
...  
Keyword(s):  
Picolinic Acid ◽  
Urinary Biomarker ◽  
Membranous Nephritis

Thermal study and characterization of new cocrystals of ciprofloxacin with picolinic acid

2021 ◽  
Author(s):  
Carolina Torquetti ◽  
Patrícia Osório Ferreira ◽  
Amanda Cosmo de Almeida ◽  
Richard Perosa Fernandes ◽  
Flávio Junior Caires
Keyword(s):  
Picolinic Acid ◽  
Thermal Study

scholarly journals Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Vincent Millischer ◽  
Matthias Heinzl ◽  
Anthi Faka ◽  
Michael Resl ◽  
Ada Trepci ◽  
...  
Keyword(s):  
Human Subjects ◽  
Picolinic Acid ◽  
Plasma Concentrations ◽  
Experimental Studies ◽  
Placebo Treatment ◽  
Kynurenine Pathway ◽  
Healthy Male ◽  
Systemic Injection ◽  
Plasma Tryptophan ◽  
Endotoxemia Model

Abstract Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS leads to induction of the kynurenine pathway followed by depressive-like behavior and cognitive dysfunction in animals. The aim of the present study is to investigate how acute intravenous LPS administration affects the kynurenine pathway in healthy male human subjects. Methods The present study is a prospective, single-blinded, randomized, placebo-controlled cross-over study to investigate the effects of intravenously administered LPS (Escherichia coli O113, 2 ng/kg) on tryptophan and kynurenine metabolites over 48 h and their association with interleukin-6 (IL-6) and C-reactive protein (CRP). The study included 10 healthy, non-smoking men (18–40 years) free from medication. Statistical differences in tryptophan and kynurenine metabolites as well as associations with IL-6 and CRP in LPS and placebo treated subjects were assessed with linear mixed-effects models. Results Systemic injection of LPS was associated with significantly lower concentrations of plasma tryptophan and kynurenine after 4 h, as well as higher concentrations of quinolinic acid (QUIN) after 48 h compared to the placebo injection. No differences were found in kynurenic acid (KYNA) or picolinic acid plasma concentrations between LPS or placebo treatment. The KYNA/kynurenine ratio peaked at 6 h post LPS injection while QUIN/kynurenine maintained significantly higher from 3 h post LPS injection until 24 h. The kynurenine/tryptophan ratio was higher at 24 h and 48 h post LPS treatment. Finally, we report an association between the kynurenine/tryptophan ratio and CRP. Conclusions Our findings strongly support the concept that an inflammatory challenge with LPS induces the kynurenine pathway in humans, activating both the neurotoxic (QUIN) and neuroprotective (KYNA) branch of the kynurenine pathway. Trial registration This study is based on a study registered at ClinicalTrials.gov, NCT03392701. Registered 21 December 2017.

scholarly journals Association between Friends’ Use of Nicotine and Cannabis and Intake of both Substances among Adolescents

2021 ◽  
Vol 18 (2) ◽  
pp. 695
Author(s):  
Rachel Herold ◽  
Rachel Boykan ◽  
Allison Eliscu ◽  
Héctor E. Alcalá ◽  
Maciej L. Goniewicz
Keyword(s):  
New York ◽  
Peer Influence ◽  
Behavioral Problems ◽  
Secondary Analysis ◽  
Cannabis Use ◽  
Urinary Biomarker ◽  
Urinary Cotinine ◽  
Multivariable Analyses ◽  
Cannabis Smoking ◽  
The Relationship

Nicotine and cannabis use are common among adolescents and may be associated with behavioral problems, poor academic outcomes and use disorders. The goals of this analysis were the following: (1) Describe the influence of friends’ nicotine and cannabis smoking and vaping on self-reported use. (2) Describe the relationship between friends’ nicotine and cannabis use on participants’ urinary biomarkers of nicotine (cotinine) and cannabis (11-nor-9-carboxy-Δ⁹tetrahydrocannabinol=THC-COOH). This is a secondary analysis of survey and biomarker data collected in adolescents aged 12–21 between April 2017 and April 2018, in Long Island, New York. Bivariate and multivariable analyses were conducted using SPSS 26. A cutoff value of ≥10 ng/mL was used to signify recent usage for urinary cotinine and THC-COOH levels. Over one-third of the 517 surveyed adolescents reported using tobacco and one-third reported using cannabis. A significant relationship between friends’ substance use and self-use was found. For both tobacco and cannabis, over 90% (p < 0.01) of participants with urinary biomarker levels above cutoff had friends who used the respective substance. Friends’ nicotine and friends’ cannabis use were each independently associated with urinary biomarker levels for those substances (for nicotine, beta = 88.29, p = 0.03; for cannabis, beta = 163.58, p = 0.03). Friends’ use of nicotine and cannabis is associated with adolescents’ intake, as well as the physiological exposure to those substances. These findings underscore the importance of including peer influence in the discussion with adolescents about tobacco and cannabis use.

N-(2-Hydroxyethyl)-l-valyl-l-leucine: a novel urinary biomarker of ethylene oxide exposure in humans

2020 ◽  
Vol 326 ◽  
pp. 18-22 ◽  
Author(s):  
Jaroslav Mráz ◽  
Iveta Hanzlíková ◽  
Šárka Dušková ◽  
Monika Tvrdíková ◽  
Igor Linhart
Keyword(s):  
Ethylene Oxide ◽  
Urinary Biomarker

scholarly journals Analysis of a Urinary Biomarker Panel for Incident Kidney Disease and Clinical Outcomes

2013 ◽  
Vol 24 (11) ◽  
pp. 1880-1888 ◽  
Author(s):  
Conall M. O’Seaghdha ◽  
Shih-Jen Hwang ◽  
Martin G. Larson ◽  
James B. Meigs ◽  
Ramachandran S. Vasan ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Clinical Outcomes ◽  
Urinary Biomarker ◽  
Biomarker Panel

scholarly journals Urinary biomarker of oxidative stress correlating with outcome in critically septic patients

2007 ◽  
Vol 33 (8) ◽  
pp. 1473-1473 ◽  
Author(s):  
Wei-Erh Cheng ◽  
Chuen-Ming Shih ◽  
Liang-Wen Hang ◽  
Kuen-Yuh Wu ◽  
Hsin-Ling Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Biomarker
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