The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial

Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a low-dose azelaic acid nanocrystal (AZA-NC) hydrogel in the treatment of mild to moderate facial acne. The study was designed as a double-blind, randomized controlled trial. Patients were randomized to treatment with AZA-NC hydrogel, 10%, or AZA cream, 20%, administered in quantities of approximately 1 g twice daily for 8 weeks. Efficacy of therapy was measured by the number of lesions and safety by the frequency and severity of adverse events. At week 8, the success rate of treatment with AZA-NC hydrogel, 10%, was 36.51% (p < 0.001) versus 30.37% (p < 0.001) with AZA cream. At week 8, treatment with AZA-NC hydrogel, 10%, resulted in a significant reduction in total inflammatory lesions from baseline of 39.15% (p < 0.001) versus 33.76% (p < 0.001) with AZA cream, and a reduction in non-inflammatory lesions from baseline of 34.58% (p < 0.001) versus 27.96% (p < 0.001) with AZA cream, respectively. The adverse event rate was low and mostly mild.

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A Meta-Analysis of Nutritional Supplementation for Management of Hospitalized Alcoholic Hepatitis

Canadian Journal of Gastroenterology ◽

10.1155/2012/945707 ◽

2012 ◽

Vol 26 (7) ◽

pp. 463-467 ◽

Cited By ~ 30

Author(s):

Ramy Antar ◽

Phil Wong ◽

Peter Ghali

Keyword(s):

Biochemical Parameters ◽

Meta Analysis ◽

Nutritional Therapy ◽

Pooled Analysis ◽

Nutritional Supplementation ◽

Mortality Benefit ◽

Randomized Controlled ◽

Balanced Diet ◽

Randomized Controlled Studies ◽

Diet Versus

BACKGROUND: Alcoholic liver disease (ALD) is associated with a high risk of morbidity and mortality. Malnutrition accompanies this condition and may be both a consequence of and contributor to the pathology. Many trials have investigated the benefits of providing supplemental nutrition in the management of patients with ALD. The present study is a meta-analysis of the available evidence.METHOD: A meta-analysis of randomized controlled studies comparing nutritional supplementation plus a normal hospital diet versus diet alone.RESULTS: Seven randomized controlled studies including 262 patients with ALD were identified. Pooled analysis revealed no statistical difference in mortality between groups given special nutritional therapy versus a normal balanced diet (OR 0.80 [95% CI 0.42 to 1.52]). In addition, nutrition did not significantly improve ascites (OR 1.29 [95% CI 0.52 to 3.20]) or any biochemical parameters. However, encephalopathy showed a significant improvement or resolution (OR 0.24 [95% CI 0.06 to 0.93]).CONCLUSION: Nutritional supplementation provided no mortality benefit in patients with ALD, and neither ascites nor biochemical parameters significantly improved. However, encephalopathy was significantly ameliorated and, therefore, nutritional supplementation should be encouraged in that setting.

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Randomized controlled trial of pimecrolimus 1% cream for treatment of facial acne vulgaris

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2004.08.012 ◽

2005 ◽

Vol 52 (4) ◽

pp. 738-739 ◽

Cited By ~ 7

Author(s):

Jerry K.L. Tan ◽

Karen Morneau ◽

Karen Fung

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Acne Vulgaris ◽

Randomized Controlled ◽

Facial Acne

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The PROMOTE study (High-protein and resistance-training combination in overweight and obesity) for short-term weight loss and long-term weight maintenance for Chinese people: a protocol for a pilot randomized controlled trial

Trials ◽

10.1186/s13063-019-3954-7 ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Shaoyong Xu ◽

Juan Zhang ◽

Yuxiang Dong ◽

Ruikun Chen ◽

Wenlei Xu ◽

...

Keyword(s):

Weight Loss ◽

Resistance Training ◽

Controlled Trial ◽

Weight Maintenance ◽

High Protein Diet ◽

Diet Group ◽

High Protein ◽

Protein Diet ◽

Short Term ◽

Low Fat Diet

Abstract Background It is very important for clinicians and dieticians to explore reasonable weight management strategies for obese people that address both short-term weight loss and subsequent weight maintenance. We hypothesized that resistance training combined with a high-protein diet would result in similar short-term weight loss but better long-term weight maintenance than either a conventional low-fat diet control or a high-protein diet alone. Methods/design This is an 8-week randomized parallel controlled trial followed by a 24-week observational follow-up study. A 48-week supplementary follow-up study will be carried out if necessary. The study will be conducted between June 2019 and October 2020. The 90 overweight or obese participants will be randomly assigned to the conventional low-fat diet group, the high-protein diet group and the high-protein diet and resistance training combination group. Primary outcomes are body weight change at week 8 and week 24 compared with the baseline level. Discussion High-quality research on the effect of a high-protein diet combined resistance training on weight loss and weight maintenance is limited in the Chinese population. Our study will provide a basis for obesity management in China and will promote the development of exercise- and diet-related studies. Trial registration Chinese Clinical Trial Registry, ChiCTR1900023841. Registered on 14 June 2019.

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