Reply to: “Laser assisted drug delivery: Enhanced response to ingenol mebutate after ablative fractional laser treatment”

2015 ◽  
Vol 72 (2) ◽  
pp. 365-366 ◽  
Author(s):  
Giuseppe Micali ◽  
Francesco Lacarrubba ◽  
Maria Rita Nasca
Keyword(s):  
Drug Delivery ◽  
Laser Treatment ◽  
Ingenol Mebutate ◽  
Fractional Laser ◽  
Ablative Fractional Laser

Fractional Laser As Laser Assisted Drug Delivery of Triamcinolone Acetonide in Keloid

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Drug Delivery ◽  
Laser Treatment ◽  
Triamcinolone Acetonide ◽  
Thermal Injury ◽  
Fractional Laser ◽  
Depth Of Penetration ◽  
Burn Scar ◽  
Intralesional Corticosteroid ◽  
Assisted Delivery ◽  
Ablative Fractional Laser

Background: Keloid is benign hyperplasia of dermal collagen which may or may not be preceded by injury in susceptible person. Keloids are refractory to treatment most of the times. Intralesional corticosteroid, topical retinoic acid, topical imiquimod cream, surgery, cryotherapy, laser, and silicon sheeting are mainly used for treatment. Fractional ablative laser is a new laser treatment modality that create numerous microscopic thermal injury zone controlled width, depth, and density that are surrounded by a reservoir of spared epidermal and dermal tissue, allowing of rapid repair of laser-induced thermal injury. Multiple studies demonstrate that laser pretreatment of the skin can increase the permeability and depth of penetration of topical drug molecules. Main observations: A boy, 12 years, scar that arise after burn scar 14 months ago. Scar was felt bigger and thickening also itching. Patient was diagnosed keloid and had been treated with same-session ablative fractional laser and topical triamcinolone acetonide after therapy. Patient had been treated 5 sessions with 3 weeks of interval. Successful of treatment was measured with reduction of keloid size and vancouver scar scale (VSS). Conclusions: Laser assisted drug delivery is an envolving technology with potentially broad clinical application. Ablative fractional laser treatment create vertical channels that might assist the delivery of drug into skin. Combination same-session therapy with ablative fractional laser and triamcinolone acetonide offer a good combination caused assisted delivery of drug.

Bacterial infections following non-ablative fractional laser treatment: A case series and discussion

2015 ◽  
Vol 47 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Lisa Y. Xu ◽  
Suzanne L. Kilmer ◽  
E. Victor Ross ◽  
Mathew M. Avram
Keyword(s):  
Laser Treatment ◽  
Bacterial Infections ◽  
Case Series ◽  
Fractional Laser ◽  
Ablative Fractional Laser

scholarly journals Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

2014 ◽  
Vol 5 (11) ◽  
pp. 3949 ◽  
Author(s):  
Chih-Hsun Yang ◽  
Meng-Tsan Tsai ◽  
Su-Chin Shen ◽  
Chau Yee Ng ◽  
Shih-Ming Jung
Keyword(s):  
Drug Delivery ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Fractional Laser ◽  
Ablative Fractional Laser

scholarly journals Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260095
Author(s):  
Joseph D. Sherrill ◽  
Deborah Finlay ◽  
Robert L. Binder ◽  
Michael K. Robinson ◽  
Xingtao Wei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wound Healing ◽  
Laser Treatment ◽  
Human Skin ◽  
Fractional Laser ◽  
Skin Rejuvenation ◽  
Skin Wound Healing ◽  
Age Related ◽  
Ablative Fractional Laser ◽  
Laser Treatments

Ablative fractional laser treatment is considered the gold standard for skin rejuvenation. In order to understand how fractional laser works to rejuvenate skin, we performed microarray profiling on skin biopsies to identify temporal and dose-response changes in gene expression following fractional laser treatment. The backs of 14 women were treated with ablative fractional laser (Fraxel®) and 4 mm punch biopsies were collected from an untreated site and at the treated sites 1, 3, 7, 14, 21 and 28 days after the single treatment. In addition, in order to understand the effect that multiple fractional laser treatments have on skin rejuvenation, several sites were treated sequentially with either 1, 2, 3, or 4 treatments (with 28 days between treatments) followed by the collection of 4 mm punch biopsies. RNA was extracted from the biopsies, analyzed using Affymetrix U219 chips and gene expression was compared between untreated and treated sites. We observed dramatic changes in gene expression as early as 1 day after fractional laser treatment with changes remaining elevated even after 1 month. Analysis of individual genes demonstrated significant and time related changes in inflammatory, epidermal, and dermal genes, with dermal genes linked to extracellular matrix formation changing at later time points following fractional laser treatment. When comparing the age-related changes in skin gene expression to those induced by fractional laser, it was observed that fractional laser treatment reverses many of the changes in the aging gene expression. Finally, multiple fractional laser treatments, which cover different regions of a treatment area, resulted in a sustained or increased dermal remodeling response, with many genes either differentially regulated or continuously upregulated, supporting previous observations that maximal skin rejuvenation requires multiple fractional laser treatments. In conclusion, fractional laser treatment of human skin activates a number of biological processes involved in wound healing and tissue regeneration.

scholarly journals Transcriptomic Analysis of Human Skin Wound Healing and Rejuvenation Following Ablative Fractional Laser Treatment

2021 ◽  
Author(s):  
Joseph D Sherrill ◽  
Deborah Finlay ◽  
Robert L Binder ◽  
Michael K Robinson ◽  
Xingtao Wei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wound Healing ◽  
Laser Treatment ◽  
Skin Wound ◽  
Fractional Laser ◽  
Skin Rejuvenation ◽  
Skin Wound Healing ◽  
Age Related ◽  
Ablative Fractional Laser ◽  
Laser Treatments

Ablative fractional laser treatment is considered the gold standard for skin rejuvenation. In order to understand how fractional laser works to rejuvenate skin, we performed microarray profiling on skin biopsies to identify temporal and dose-response changes in gene expression following fractional laser treatment. The backs of 14 women were treated with ablative fractional laser (Fraxel) and 4 mm punch biopsies were collected from an untreated site and at the treated sites 1, 3, 7, 14, 21 and 28 days after the single treatment. In addition, in order to understand the effect that multiple fractional laser treatments have on skin rejuvenation, several sites were treated sequentially with either 1, 2, 3, or 4 treatments (with 28 days between treatments) followed by the collection of 4 mm punch biopsies. RNA was extracted from the biopsies, analyzed using Affymetrix U219 chips and gene expression was compared between untreated and treated sites. We observed dramatic changes in gene expression as early as 1 day after fractional laser treatment with changes remaining elevated even after 1 month. Analysis of individual genes demonstrated significant and time related changes in inflammatory, epidermal, and dermal genes, with dermal genes linked to extracellular matrix formation changing at later time points following fractional laser treatment. When comparing the age-related changes in skin gene expression to those induced by fractional laser, it was observed that fractional laser treatment reverses many of the changes in the aging gene expression. Finally, multiple fractional laser treatments resulted in continued changes in gene expression, with many genes either differentially regulated or continuously upregulated with increasing number of treatments, indicating that maximal skin rejuvenation requires multiple fractional laser treatments. In conclusion, fractional laser treatment of skin activates several biological processes involved in wound healing and tissue regeneration, all of which significantly contribute to the rejuvenating effect of fractional laser treatment on aged skin.

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