Reply to: “Re: Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study”

BACKGROUND In many parts of the world, polymorphous light eruption (PLE) is the commonest cause of photosensitivity. Previous studies have suggested the association of PLE with multiple autoimmune diseases. Few studies are available suggesting the association of PLE with autoimmune thyroiditis. We have undertaken this study to conrm such an association and to predict which cases of PLE are likely to have hypothyroidism and autoimmune thyroiditis. METHODS This was a cross-sectional study with comparative group with 75 PLE cases and 75 controls. Thyroid function test (TFT) was done for all subjects and, if found abnormal, anti-thyroid peroxidase (TPO) antibodies were tested. The studied parameters were compared using Pearson's chi-squared test for signicance. RESULTS The male to female ratio was 1:2.1. Hypothyroidism and autoimmune thyroiditis were signicantly present in PLE cases. PLE lesions with papular morphology, persistent and recurrent PLE, positive family history and associated other autoimmune diseases were signicantly associated with autoimmune thyroiditis. CONCLUSION PLE is signicantly associated with hypothyroidism and autoimmune thyroiditis. Hence we suggest screening of PLE patients for hypothyroidism and, if required, for autoimmune thyroiditis for early diagnosis and treatment.

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Atopic dermatitis and systemic autoimmune diseases: A descriptive cross sectional study

Dermatology Online Journal ◽

10.5070/d33sf31124 ◽

2006 ◽

Vol 12 (3) ◽

Author(s):

Vida Feizy ◽

Arefeh Ghobadi

Keyword(s):

Atopic Dermatitis ◽

Autoimmune Diseases ◽

Cross Sectional Study ◽

Sectional Study ◽

Systemic Autoimmune Diseases ◽

Cross Sectional

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Spondyloarthropathies in Autoimmune Diseases and Vice Versa

Autoimmune Diseases ◽

10.1155/2012/736384 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Oscar M. Pérez-Fernández ◽

Rubén D. Mantilla ◽

Paola Cruz-Tapias ◽

Alberto Rodriguez-Rodriguez ◽

Adriana Rojas-Villarraga ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Systemic Lupus Erythematosus ◽

Autoimmune Diseases ◽

Lupus Erythematosus ◽

Clinical Characteristics ◽

Cross Sectional Study ◽

Sectional Study ◽

Systemic Lupus ◽

Two Phase ◽

Cross Sectional

Polyautoimmunity is one of the major clinical characteristics of autoimmune diseases (ADs). The aim of this study was to investigate the prevalence of ADs in spondyloarthropathies (SpAs) and vice versa. This was a two-phase cross-sectional study. First, we examined the presence of ADs in a cohort of patients with SpAs (N=148). Second, we searched for the presence of SpAs in a well-defined group of patients with ADs (N=1077) including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren’s syndrome (SS). Among patients with SpAs, ankylosing spondylitis was observed in the majority of them (55.6%). There were two patients presenting with SS in the SpA group (1.4%) and 5 patients with autoimmune thyroiditis (3.5%). The global prevalence of ADs in SpAs was 4.86%. In the ADs group, there were 5 patients with SpAs (0.46%). Our results suggest a lack of association between SpAs and ADs. Accordingly, SpAs might correspond more to autoinflammatory diseases rather than to ADs.

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Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

10.20944/preprints202108.0162.v1 ◽

2021 ◽

Author(s):

Maria del Carmen Moleon ◽

Estrella Martinez-Gomez ◽

Marisa Flook ◽

Andreina Peralta-Leal ◽

Juan Antonio Gallego ◽

...

Keyword(s):

Autoimmune Diseases ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

Cross Sectional Study ◽

Cytokine Profile ◽

Sectional Study ◽

Meniere Disease ◽

Cross Sectional ◽

Menière Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profile in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early onset MD (EOMD, <35 years old), and 39 with late onset MD (LOMD, > 50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p=0.004) and a higher prevalence of migraine than LOMD (p=0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3 and CXCL4 were different between patients with MD or migraine and controls.

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The prevalence of autoimmune diseases in patients with multiple sclerosis: A cross-sectional study in Qom, Iran, in 2018

Current Journal of Neurology ◽

10.18502/cjn.v19i3.5421 ◽

2021 ◽

Author(s):

Nazanin Ershadinia ◽

Nader Mortazavinia ◽

Sepideh Babaniamansour ◽

Mahdi Najafi-Nesheli ◽

Parto Babaniamansour ◽

...

Keyword(s):

Multiple Sclerosis ◽

Autoimmune Disease ◽

Autoimmune Diseases ◽

Hashimoto’S Thyroiditis ◽

Cross Sectional Study ◽

Hashimoto's Thyroiditis ◽

Sectional Study ◽

Cross Sectional ◽

Duration Of Disease

Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases worldwide and various autoimmune comorbidities are reported with MS. The objective of this study is to estimate the prevalence of the autoimmune diseases’ comorbidity in patients with MS. Methods: In this cross-sectional study, we investigated a group of patients with MS in terms of age, gender, duration of MS, presence of simultaneous autoimmune diseases, such as Graves’ disease, Hashimoto’s thyroiditis, type 1 diabetes mellitus (DM), and systemic lupus erythematous (SLE). Results: This study included 1215 patients with MS, of which 70.8% were women. The mean age of participants was 33.70 ± 27.63 years. 55 patients (4.5%) had at least one autoimmune disease. The most common comorbidity was for Hashimoto’s thyroiditis (30 patients). The frequency of simultaneous autoimmune disease was higher in women. Mean age (P = 0.01), mean duration of MS (P = 0.03), and mean age on MS diagnosis (P = 0.02) were significantly higher in simultaneous MS and other autoimmune diseases. Conclusion: Our study revealed that the probability of autoimmune diseases co-occurrence in patients with MS could be higher in older patients, in longer duration of disease, and also in patients with higher age at time of MS diagnosis.

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