TCT-661 Assessments of Lipid Plaque and Thrombus With a Novel High-Definition 60-MHz IVUS Imaging System: Comparison with Conventional 40-MHz IVUS and Optical Coherence Tomography

Characterization of bladder biopsies, using a combined fiber optic probe-based optical coherence tomography and Raman spectroscopy imaging system that allows a large field-of-view imaging and detection and grading of cancerous bladder lesions.

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Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging

Journal of VitreoRetinal Diseases ◽

10.1177/2474126421997335 ◽

2021 ◽

pp. 247412642199733

Author(s):

Kyle D. Kovacs ◽

M. Abdallah Mahrous ◽

Luis Gonzalez ◽

Benjamin E. Botsford ◽

Tamara L. Lenis ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Clinical Utility ◽

Clinical Decision Making ◽

Imaging System ◽

Imaging Modality ◽

Case Series ◽

Subretinal Fluid ◽

Optical Coherence ◽

Swept Source ◽

Oct Imaging

Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) imaging system. Methods: A retrospective, single-center, consecutive case series evaluated patients between September 2019 and October 2020 with UWF SS-OCT (modified Optos P200TxE, Optos PLC) as part of routine retinal care. The logistics of image acquisition, interpretability of images captured, nature of the peripheral abnormality, and clinical utility in management decisions were recorded. Results: Eighty-two eyes from 72 patients were included. Patients were aged 59.4 ± 17.1 years (range, 8-87 years). During imaging, 4.4 series of images were obtained in 4.1 minutes, with 86.4% of the image series deemed to be diagnostic of the peripheral pathology on blinded image review. The most common pathologic findings were chorioretinal scars (18 eyes). In 31 (38%) eyes, these images were meaningful in supporting clinical decision-making with definitive findings. Diagnoses imaged included retinal detachment combined with retinoschisis, retinal hole with overlying vitreous traction and subretinal fluid, vitreous inflammation overlying a peripheral scar, Coats disease, and peripheral retinal traction in sickle cell retinopathy. Conclusions: Navigated UWF SS-OCT imaging was clinically practical and provided high-quality characterization of peripheral retinal lesions for all eyes. Images directly contributed to management plans, including laser, injection or surgical treatment, for a clinically meaningful set of patients (38%). Future studies are needed to further assess the value of this imaging modality and its role in diagnosing, monitoring, and treating peripheral lesions.

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Synthetic polarization-sensitive optical coherence tomography by deep learning

npj Digital Medicine ◽

10.1038/s41746-021-00475-8 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Yi Sun ◽

Jianfeng Wang ◽

Jindou Shi ◽

Stephen A. Boppart

Keyword(s):

Optical Coherence Tomography ◽

Deep Learning ◽

Imaging System ◽

Imaging Modality ◽

Similarity Index ◽

Polarization Sensitivity ◽

Imaging Method ◽

Optical Coherence ◽

The Real ◽

Oct Imaging

AbstractPolarization-sensitive optical coherence tomography (PS-OCT) is a high-resolution label-free optical biomedical imaging modality that is sensitive to the microstructural architecture in tissue that gives rise to form birefringence, such as collagen or muscle fibers. To enable polarization sensitivity in an OCT system, however, requires additional hardware and complexity. We developed a deep-learning method to synthesize PS-OCT images by training a generative adversarial network (GAN) on OCT intensity and PS-OCT images. The synthesis accuracy was first evaluated by the structural similarity index (SSIM) between the synthetic and real PS-OCT images. Furthermore, the effectiveness of the computational PS-OCT images was validated by separately training two image classifiers using the real and synthetic PS-OCT images for cancer/normal classification. The similar classification results of the two trained classifiers demonstrate that the predicted PS-OCT images can be potentially used interchangeably in cancer diagnosis applications. In addition, we applied the trained GAN models on OCT images collected from a separate OCT imaging system, and the synthetic PS-OCT images correlate well with the real PS-OCT image collected from the same sample sites using the PS-OCT imaging system. This computational PS-OCT imaging method has the potential to reduce the cost, complexity, and need for hardware-based PS-OCT imaging systems.

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High-definition optical coherence tomography of melanocytic skin lesions

Journal of Biophotonics ◽

10.1002/jbio.201400085 ◽

2014 ◽

Vol 8 (8) ◽

pp. 681-686 ◽

Cited By ~ 28

Author(s):

Thilo Gambichler ◽

Iris Plura ◽

Monika Schmid-Wendtner ◽

Konstantinos Valavanis ◽

Daniela Kulichova ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Skin Lesions ◽

Optical Coherence ◽

High Definition

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Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

Optics Letters ◽

10.1364/ol.41.001636 ◽

2016 ◽

Vol 41 (7) ◽

pp. 1636 ◽

Cited By ~ 16

Author(s):

Zhongjiang Chen ◽

Sihua Yang ◽

Da Xing

Keyword(s):

Optical Coherence Tomography ◽

Fluorescence Imaging ◽

Imaging System ◽

Optical Coherence ◽

Photoacoustic Microscopy ◽

All Optical

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Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

International Journal of Optics ◽

10.1155/2018/3726207 ◽

2018 ◽

Vol 2018 ◽

pp. 1-22 ◽

Cited By ~ 4

Author(s):

Farid Atry ◽

Israel Jacob De La Rosa ◽

Kevin R. Rarick ◽

Ramin Pashaie

Keyword(s):

Optical Coherence Tomography ◽

Imaging System ◽

Optical Design ◽

Spectral Domain ◽

Design Parameters ◽

Optical Coherence ◽

Custom Made ◽

Essential Knowledge ◽

Sd Oct

In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to develop custom-made scanners that suit specific applications. This paper aims to provide a detailed discussion on the design and development process of a typical SD-OCT scanner. The effects of multiple design parameters, for the main optical and optomechanical components, on the overall performance of the imaging system are analyzed and discussions are provided to serve as a guideline for the development of a custom SD-OCT system. While this article can be generalized for different applications, we will demonstrate the design of a SD-OCT system and representative results for in vivo brain imaging. We explain procedures to measure the axial and transversal resolutions and field of view of the system and to understand the discrepancies between the experimental and theoretical values. The specific aim of this piece is to facilitate the process of constructing custom-made SD-OCT scanners for research groups with minimum understanding of concepts in optical design and medical imaging.

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