scholarly journals GW29-e0322 Role of interleukin-34 in predicting the aggravation of heart failure and long-term prognosis in patients with myocardial infarction

2018 ◽  
Vol 72 (16) ◽  
pp. C162
Author(s):  
Qin Fan ◽  
Xiaoxiang Yan ◽  
Hang Zhang ◽  
Hongyang Xie ◽  
Rui Xi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Long Term Prognosis

scholarly journals The relevance of prescribing triple neurohormonal blockade in real clinical practice: the role of mineralocorticoid receptor antagonists

2021 ◽  
Vol 23 (6) ◽  
pp. 491-497
Author(s):  
Igor V. Zhirov ◽  
◽  
Igor V. Zhirov ◽  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Mineralocorticoid Receptor ◽  
Systolic Dysfunction ◽  
Term Treatment ◽  
Mineralocorticoid Receptor Antagonists ◽  
Long Term Treatment ◽  
Real Clinical Practice

In the article is outlined the main concepts use of the mineralocorticoids receptors antagonists in the treatment of congestive heart failure and systolic dysfunction after acute myocardial infarction. Claimed the pivotal role of eplerenone in the long-term treatment strategy due to decrease of mortality and improving the clinical outcomes.

scholarly journals Long-term Prognosis Analysis of PARACHUTE Device Implantation in Patients with Ischemic Heart Failure: A Single-Center Experience of Chinese patients

2020 ◽  
Author(s):  
Jianghua Li ◽  
Huadong Liu ◽  
Qiyun Liu ◽  
Cheng Liu ◽  
Wei Xiong ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Left Ventricular ◽  
Chinese Patients ◽  
Device Implantation ◽  
Lv Ejection Fraction ◽  
Long Term Prognosis ◽  
Apical Aneurysm

Abstract Background: Heart failure (HF) is one of the leading causes of mortality and morbidity. The PARACHUTE device is designed to partition for left ventricular (LV) apical aneurysm post extensive anterior myocardial infarction. However, the long-term prognosis of the PARACHUTE device post-implantation is unclear.Methods：From November 2015 to April 2017, six subjects with New York Heart Association Class II, III and IV ischemic HF, LV ejection fraction between 15% and 40%, and LV anterior apical aneurysm were enrolled in our center. The cumulative event rates for myocardial infarction, hospitalization, and mortality were documented respectively. Further assessment of LV ejection fraction, LV end-diastolic diameter, and estimated pulmonary artery pressure were determined by echocardiography core laboratory. For quantitative data comparison, paired t‑test was employed.Results: Device implantation was successful in all six enrolled subjects, and acute device association adverse events were not observed. At 4.6 ± 1.7 years follow-up, MACEs were found in 50% patients, and the survival rate was 86.7%. We found that the LV ejection fraction was significantly elevated after deployment (46.00 ± 6.00% vs. 35.83 ± 1.47%, P=0.009). Besides, the LVEDD elevated after MI (51.17 ± 3.71 vs. 62.83 ± 3.25, P<0.001) was revealed, but the device sustained preserved LVEDD after implantation.Conclusion: The PARACHUTE device is an alternative therapy for patients with severe LV maladaptive remodeling. The procedure of PARACHUTE implantation is safe and has a potential benefit in long-term mortality reduction. However, the device seems to increase the HF ratio.Clinical Trial Registration: NCT02240940, https://clinicaltrials.gov/ct2/ show/NCT02240940

scholarly journals Long-term prognosis and a nomogram model for postoperative acute heart failure in patients with acute myocardial infarction

2020 ◽  
Author(s):  
Zhaodong Guo ◽  
Guoli Sun ◽  
Feier Song ◽  
Li Lei ◽  
Yibo He ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Acute Heart Failure ◽  
Kidney Injury ◽  
Final Analysis ◽  
Adequate Hydration ◽  
Long Term Prognosis ◽  
Long Term Mortality

Abstract Background Undefined adequate hydration may increase the risk of postoperative acute heart failure (AHF) while reducing the risk of contrast-induced acute kidney injury (CI-AKI) in patients with acute myocardial infarction (AMI). No relevant study exists regarding the association of postoperative AHF and long-term prognosis. This study is to evaluate the all-cause long-term mortality and establish a nomogram model for predicting postoperative AHF in this patient group. Methods In this prospective observational study, 1312 AMI patients undergoing coronary angiography (CAG) were included in the final analysis. Patients were assigned into a non-postoperative AHF-group (n=1235) or a postoperative AHF-group (n=77). The diagnosis of postoperative AHF was based on assessing symptom history, prior cardiovascular history, and potential cardiac and non-cardiac precipitants. Results The overall incidence of postoperative AHF was 77/1312 (5.9%). The incidence of all-cause long-term mortality was significantly higher in the postoperative AHF-group than in the non-postoperative AHF-group (50.6% vs. 17.0%, P<0.01). The median follow-up period was 7.0 years (interquartile range: 5.5 – 8.7). After adjusting for female, LVEF, eGFR, anemia, hypertension, diabetes mellitus, and PCI, postoperative AHF was the strongest predictor of all-cause long-term mortality (hazard ratio: 3.11; 95% CI: 1.83 – 5.30; P<0.01). A nomogram developed based on the four variables was with the AUC 0.83 on internal validation. Calibration curve showed that the predicted and actual probabilities of postoperative AHF were fitted well. Conclusions In patients with AMI undergoing CAG, postoperative AHF is the strongest predictor of all-cause long-term mortality. The nomogram showed an effective value of predicting postoperative AHF using preoperative predictions.

scholarly journals Peripartum cardiomyopathy

2011 ◽  
Vol 2 (3) ◽  
pp. 161
Author(s):  
Rodolfo Citro ◽  
Roberta Giudice ◽  
Marco Mirra ◽  
Rosa Paolillo ◽  
Chiara Paolillo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systolic Dysfunction ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Peripartum Cardiomyopathy ◽  
Multicenter Trials ◽  
Autoimmune Processes ◽  
Long Term Prognosis

Peripartum cardiomyopathy is an uncommon form of congestive heart failure associated with systolic dysfunction of left ventricle. The onset is characterised by symptoms of heart failure occurring between the last month of pregnancy and 5-6 months postpartum. The early diagnosis and the institution of medical treatment for this disease are essential because the inadequate management may affect the patient’s long-term prognosis and can lead to severe complications, including death.Currently its aetiology is not completely understood. Many aetiopathogenetic hypotheses have been formulated: inflammation, viral agents, autoimmune processes. In the last years, evidences aroused for a role of prolactin and its 16 kDa metabolite in reducing cardiomyocite metabolic activity and contraction. In this article we have reviewed the current literature with special emphasis on the role of prolactin and the related current treatment strategies. In particular, bromocriptine appears promising, even if women need to be informed that the drug stops the production of breastmilk. Further researchers, such as large multicenter trials, are needed to decide the best treatment for the women suffering of this disease.

4939Clinical significance of global strain estimated by 3D speckle tracking acutely after onset of ST-elevation myocardial infarction on prediction of long term prognosis

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
N Iwahashi ◽  
J K Kirigaya ◽  
M H Horii ◽  
E A Akiyama ◽  
K O Okada ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Cardiac Death ◽  
Speckle Tracking ◽  
Kaplan Meier ◽  
Global Strain ◽  
St Elevation ◽  
Long Term Prognosis ◽  
First Time

Abstract Background Three-dimensional (3D) speckle tracking echocardiography (STE) is a novel method for assessing cardiac function because of free form out-of-plane motion effects. Aim To explore the role of 3D-STE for prediction of the long term prognosis in patients with a first-time ST elevation acute myocardial infarction (STEMI). Methods A total of 238 patients (mean age 64.6 years) with a first-time STEMI treated with reperfusion therapy were enrolled in our study. Twenty four hours after admission, standard 2D echocardiography and 3D full volume imaging were obtained and strain parameters (GLS: global longitudinal strain, GCS: global circumferential strain) were calculated using 4D LV analysis. Infarct size was measured with single-photon emission computed tomography imaging 7 to 14 days after onset. We followed them for median 94 months (inter quartile range: 69–109 months). The primary end point was the major adverse cardiac and cerebrovascular events (MACE: cardiac death, non-fatal MI, heart failure requiring intravenous diuretics administration and stroke). The patients with persistent chronic atrial fibrillation, poor image quality, emergency bypass surgery were excluded. Results During follow up periods, 78 patients experienced MACE (26 cardiac death, 48 heart failure, 29 non-fatal MI, 5 stroke) and 48 patients died (22 non-cardiac death). In multivariate analysis, 3D-GLS was the strongest predictor for MACE. Kaplan-Meier Curve demonstrated that 3D-GLS >−11.4 was the independent predictor for MACE (Log-rank χ2=73.818, p<0.0001). When combined with 3D-GCS >−19.2, the patients with higher value both of 3D-GLS and 3D-GCS were extremely high risk. The figure shows the Kaplan-Meier curve according to the 4 groups based on the cut-off values determinded by ROC curves. Conclusions Global strain estimated by 3D-STE immediately onset of STEMI was useful tool for the prediction of long term prognosis. Acknowledgement/Funding None

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