Impaired Lymph-Node Homing of Dendritic Cells (DC) in Allergen-Challenged Surfactant Protein D Deficient (SP-D-/-) Mice is Associated with Lack of Ccr7 and Reduced Expression of Signal Regulatory Protein-Alpha (Sirp-α)

2011 ◽  
Vol 127 (2) ◽  
pp. AB270-AB270
Author(s):  
L.R. Forbes ◽  
C. Koziol-White ◽  
B. Ducka ◽  
M. Fehrenbach ◽  
A. Haczku
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
Regulatory Protein ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Lymph Node Homing

scholarly journals Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure

2015 ◽  
Vol 196 (2) ◽  
pp. 553-557 ◽  
Author(s):  
Moyar Qing Ge ◽  
Blerina Kokalari ◽  
Cameron H. Flayer ◽  
Sarah S. Killingbeck ◽  
Imre G. Redai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Dendritic Cell ◽  
Nk Cells ◽  
Surfactant Protein ◽  
Cutting Edge ◽  
Ozone Exposure ◽  
Surfactant Protein D ◽  
Lymph Node Homing

scholarly journals Correction: Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure

2016 ◽  
Vol 196 (7) ◽  
pp. 3212-3212 ◽  
Author(s):  
Moyar Qing Ge ◽  
Blerina Kokalari ◽  
Cameron H. Flayer ◽  
Sarah S. Killingbeck ◽  
Imre G. Redai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Dendritic Cell ◽  
Nk Cells ◽  
Surfactant Protein ◽  
Cutting Edge ◽  
Ozone Exposure ◽  
Surfactant Protein D ◽  
Lymph Node Homing

Lymph node homing of T cells and dendritic cells via afferent lymphatics

2012 ◽  
Vol 33 (6) ◽  
pp. 271-280 ◽  
Author(s):  
Reinhold Förster ◽  
Asolina Braun ◽  
Tim Worbs
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Lymph Node Homing

MYCOPHENOLIC ACID IMPEDES ANTIGEN PRESENTING AND LYMPH NODE HOMING CAPACITIES OF HUMAN BLOOD MYELOID DENDRITIC CELLS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 727-728
Author(s):  
V R. Cicinnati ◽  
J Hou ◽  
M Lindemann ◽  
A Radtke ◽  
C G. Klein ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
Human Blood ◽  
Mycophenolic Acid ◽  
Myeloid Dendritic Cells ◽  
Lymph Node Homing ◽  
Antigen Presenting

scholarly journals All-trans-Retinoic Acid Imprints Expression of the Gut-Homing Marker α4β7 while Suppressing Lymph Node Homing of Dendritic Cells

2013 ◽  
Vol 20 (10) ◽  
pp. 1642-1646 ◽  
Author(s):  
Tristan I. Evans ◽  
R. Keith Reeves
Keyword(s):  
Dendritic Cells ◽  
Retinoic Acid ◽  
Lymph Node ◽  
Ex Vivo ◽  
Dependent Manner ◽  
Atra Treatment ◽  
Lymph Node Homing ◽  
All Trans Retinoic Acid ◽  
Trafficking Receptor ◽  
Dose Dependent

ABSTRACTTissue-directed trafficking of dendritic cells (DCs) as natural adjuvants and/or direct vaccine carriers is highly attractive for the next generation of vaccines and immunotherapeutics. Since these types of studies would undoubtedly be first conducted using nonhuman primate models, we evaluated the ability of all-trans-retinoic acid (ATRA) to induce gut-homing α4β7 expression on rhesus macaque plasmacytoid and myeloid DCs (pDCs and mDCs, respectively). Induction of α4β7 occurred in both a time-dependent and a dose-dependent manner with up to 8-fold increases for mDCs and 2-fold increases for pDCs compared to medium controls. ATRA treatment was also specific in inducing α4β7 expression, but not expression of another mucosal trafficking receptor, CCR9. Unexpectedly, upregulation of α4β7 was associated with a concomitant downregulation of CD62L, a marker of lymph node homing, indicating an overall shift in the trafficking repertoire. These same phenomena occurred with ATRA treatment of human and chimpanzee DCs, suggesting a conserved mechanism among primates. Collectively, these data serve as a first evaluation forex vivomodification of primate DC homing patterns that could later be used in reinfusion studies for the purposes of immunotherapeutics or mucosa-directed vaccines.

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