The association of the blood lead level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2A polymorphisms rs10636 GC and rs28366003 AA

AbstractBackgroundThe aim of this study was to know the present scenario of blood lead level and its effect on serum lipid peroxide and antioxidant parameters of spray painters.MethodsWe included 42 male spray painters and 50 control subjects with an age range of 20–45 years. Blood lead level, serum lipid peroxide and antioxidant parameters, i.e. erythrocyte catalase, superoxide dismutase (SOD), plasma ceruloplasmin, nitric oxide, uric acid and bilirubin, were quantified by standard methods.ResultsWe observed the significant elevated blood lead (p < 0.001, 458%), lipid peroxide (p < 0.001, 170%), uric acid (p < 0.001, 25.6%) and bilirubin (p < 0.01, 24.5%) and the significant decrease in antioxidant enzymes like SOD (p < 0.001, −50.4%), catalase (p < 0.001, −34.33%), ceruloplasmin (p < 0.001, −32.7%) and nitric oxide (p < 0.001, −39.58%) in the study group as compared to control. A significant positive correlation coefficient (r) of blood lead level with lipid peroxide (r = 0.44, p < 0.001), uric acid (r = 0.33 p < 0.05) and bilirubin (r = 0.35, p < 0.05) and a negative correlation with SOD (r = −0.32, p < 0.05), catalase (r = −0.33, p < 0.05), ceruloplasmin (r = −0.27, p < 0.05) and nitric oxide (r = 0.30, p < 0.05) were observed.ConclusionsElevated blood lead level induces serum lipid peroxide and alters the antioxidant enzymes of spray painters. Therefore, it is necessary to reduce the blood lead level by taking proper precautions while spraying the paints, and additional antioxidant supplementation like vitamin C, multivitamin and multiminerals will be useful in reducing oxidative stress.

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Association between Blood Lead Level and Gout: The United States National Health Nutrition and Examination Survey 2007-2016

SSRN Electronic Journal ◽

10.2139/ssrn.3537105 ◽

2020 ◽

Author(s):

Man-Fung Tsoi ◽

Bernard Man Yung Cheung ◽

Chak Sing Lau ◽

Tommy Cheung

Keyword(s):

United States ◽

National Health ◽

Blood Lead Level ◽

Lead Level ◽

Blood Lead ◽

The United States

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Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016

Scientific Reports ◽

10.1038/s41598-021-82435-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Man Fung Tsoi ◽

Chris Wai Hang Lo ◽

Tommy Tsang Cheung ◽

Bernard Man Yung Cheung

Keyword(s):

Blood Pressure ◽

Lead Exposure ◽

Blood Lead Level ◽

Lead Level ◽

Blood Lead ◽

The United States ◽

Study Data ◽

Blood Lead Levels ◽

Environmental Lead ◽

Lead Levels

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.

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Blood lead level as a criterion of global pollution

Bulletin of Environmental Contamination and Toxicology ◽

10.1007/bf00199062 ◽

1992 ◽

Vol 48 (4) ◽

Cited By ~ 8

Author(s):

Dagmar Kalavsk�

Keyword(s):

Blood Lead Level ◽

Lead Level ◽

Blood Lead ◽

Global Pollution

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Hardness of Domestic Water and Blood Lead Levels

Human Toxicology ◽

10.1177/096032718300200411 ◽

1983 ◽

Vol 2 (4) ◽

pp. 645-648 ◽

Cited By ~ 13

Author(s):

P.C. Elwood ◽

K.M. Phillips ◽

N. Lowe ◽

J.K. Phillips ◽

C. Toothill

Keyword(s):

Blood Lead Level ◽

Lead Level ◽

Blood Lead ◽

Hard Water ◽

Control Area ◽

Blood Lead Levels ◽

Domestic Water ◽

Solvent Water ◽

Small Rise ◽

Lead Levels

1 The effect on the blood lead levels of residents in an area in which a soft plumbo-solvent water was hardened is examined. 2 Water lead levels fell after hardening was introduced whereas there was a small rise in water lead levels in a control area monitored over the same time. 3 The blood lead levels of residents fell after hardening and the fall was slightly greater than would have been predicted on the basis of the change in water lead levels. This suggests that lead is less well absorbed from hard water than from soft water. 4 Following hardening there was a significant fall in mean blood lead level of subjects living in houses which had initially had negligible amounts of lead in the water. This suggests that hard water may interfere with the absorption of lead from sources other than water.

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Lead Poisoning: Twenty Years After

PEDIATRICS ◽

10.1542/peds.92.3.505 ◽

1993 ◽

Vol 92 (3) ◽

pp. 505-505

Author(s):

HENRIETTA SACHS ◽

DONALD I. MOEL

Keyword(s):

Disease Control ◽

Lead Poisoning ◽

Blood Lead Level ◽

Scientific Evidence ◽

Lead Level ◽

Blood Lead ◽

Neurobehavioral Development ◽

Long Term Follow Up

To the Editor.— In October 1991, the Centers for Disease Control decreased the blood lead level PbB) from 25 to 10 µg/dL and designated it as abnormal because of "overwhelming and compelling scientific evidence"1 that 10 µg/dL is associated with adverse neurobehavioral development. We have evidence to the contrary, obtained in a long-term follow-up of severely lead-poisoned children whom we treated before 1972 for PbBs between 80 and 470 µg/dL (mean, 150.3 ± 77.1 µg/dL); their mean age was 28 months.

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Chronic Environmental and Occupational Lead Exposure and Kidney Function among African Americans: Dallas Lead Project II

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15122875 ◽

2018 ◽

Vol 15 (12) ◽

pp. 2875 ◽

Cited By ~ 2

Author(s):

Robert Reilly ◽

Susan Spalding ◽

Brad Walsh ◽

Jeanne Wainer ◽

Sue Pickens ◽

...

Keyword(s):

African Americans ◽

Kidney Function ◽

Lead Exposure ◽

Environmental Protection Agency ◽

Blood Lead Level ◽

Lead Level ◽

Blood Lead ◽

Lead Smelter ◽

Male And Female ◽

Negative Effect

Background: We examined the effects of lead on kidney function in occupationally and environmentally exposed adults from a Dallas lead smelter community that was the site of an Environmental Protection Agency (EPA) Superfund clean-up. All subjects were African Americans—a racial group that bears a disproportionate burden of kidney disease. Methods: A two-phase health screening was conducted. Phase II included a physical examination and laboratory tests. Study subjects were African Americans residents, aged ≥19 years to ≤89 years. Of 778 subjects, 726 were environmentally exposed and 52 were both occupationally and environmentally exposed. The effects of lead exposure on estimated glomerular filtration rate (eGFR) were examined in three groups: male and female smelter-community residents, as well as males with both occupational and environmental exposure. Multiple linear regression was used to analyze the dependence of eGFR on log (blood lead level), duration of residence in the community, type 2 diabetes, and hypertension. Results: There was a statistically significant negative effect on kidney function for all three groups. Comparison of female and male residents showed a slightly larger negative effect of blood lead level on eGFR in females versus males, with the largest effect seen in male smelter-working residents. For each unit increase (log10 10µg/dL = 1) in blood lead level, age-adjusted eGFR was reduced 21.2 mL/min/1.73 m2 in male residents, 25.3 mL/min/1.73 m2 in female residents and 59.2 mL/min/1.73 m2 in male smelter-working residents. Conclusions: Chronic lead exposure is associated with worsening kidney function in both African American male and female residents, as well as male workers in Dallas smelter communities. This effect is slightly, but not statistically significantly, worse in female residents than male residents, and significantly worse in males that both worked and resided in the smelter community.

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