Extreme elevations of low-density lipoprotein cholesterol with very low carbohydrate, high fat diets

2021 ◽  
Author(s):  
Anna E. Schaffer ◽  
David A. D'Alessio ◽  
John R. Guyton
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Data mining: traditional spring festival associated with hypercholesterolemia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Danchen Wang ◽  
Yutong Zou ◽  
Honglei Li ◽  
Songlin Yu ◽  
Liangyu Xia ◽  
...  
Keyword(s):  
Information System ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
High Fat ◽  
College Hospital ◽  
Cross Sectional ◽  
Spring Festival ◽  
High Fat Diets ◽  
Fat Diets

Abstract Background Serum lipid concentrations are affected by long-term high-fat diets; thus, we hypothesize that lipid levels increase after the Spring Festival in China. Method In total, 20,192 individuals (male: n=10,108, female: n=10,084) were enrolled in this retrospective cross-sectional study based on clinical data from the Laboratory Information System (LIS) and Hospital Information System (HIS) in Peking Union Medical College Hospital from 2014 to 2018. Total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were analyzed. Results The serum TC [male vs. female: (4.71 ± 0.90 vs. 4.56 ± 0.85) mmol/L], TG [male vs. female: (1.71 ± 1.56 vs. 1.02 ± 0.68) mmol/L], and LDL-C [male vs. female: (3.01 ± 0.77 vs. 2.73 ± 0.74) mmol/L] levels were significantly higher in males than in females (P < 0.001); serum HDL-C [male vs. female: (1.18 ± 0.28 vs. 1.50 ± 0.34) mmol/L] was significantly lower in males (P < 0.001). In February, the TC, TG, and LDL-C levels were 8.4%, 16.3%, and 9.3% higher than the lowest levels recorded, respectively. The prevalence of dyslipidemia of the two weeks before the Spring festival was significantly lower than that of the first week after the Spring festival (43.6% (168/385) vs. 54.1% (126/233), P=0.007). Additionally, the prevalence of dyslipidemia was statistically higher in the first week after the Spring Festival than in May–January. Conclusion Higher TC, TG, and LDL-C in winter could be associated with high-fat diets during the Spring Festival. The Spring Festival was immediately followed by a higher lipid concentrations. Thus, we don't recommend lipid assessment or physical examination immediately after the holiday especially Spring festival.

Effect of short-term low- and high-fat diets on low-density lipoprotein particle size in normolipidemic subjects

Metabolism ◽  
2012 ◽  
Vol 61 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Valérie Guay ◽  
Benoît Lamarche ◽  
Amélie Charest ◽  
André J. Tremblay ◽  
Patrick Couture
Keyword(s):  
Particle Size ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
High Fat ◽  
Short Term ◽  
Lipoprotein Particle ◽  
High Fat Diets ◽  
Lipoprotein Particle Size ◽  
Fat Diets

Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets

Metabolism ◽  
1995 ◽  
Vol 44 (8) ◽  
pp. 1058-1066 ◽  
Author(s):  
Rampratap S. Kushwaha ◽  
P.Hugh R. Barrett ◽  
Catherine A. Reardon ◽  
Douglas S. Lewis ◽  
K.D. Carey ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats

2021 ◽  
Author(s):  
Maria Donatella Semeraro ◽  
Gunter Almer ◽  
Melanie Kaiser ◽  
Sieglinde Zelzer ◽  
Andreas Meinitzer ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Low Density Lipoprotein Cholesterol ◽  
High Fat ◽  
Nitric Oxide Metabolites

Abstract Purpose Regular exercise reduces obesity and the risk of cardiovascular disease. However, health-promoting benefits of physical activity are commonly associated with increased inflammation and oxidative stress. Here, we tested whether constant moderate exercise is able to prevent or attenuate the oxidative/nitrosative stress, inflammation, and serum lipids in lean and obese rats. Methods Four-month-old female Sprague Dawley rats received standard or a high-fat diet. Animals were subjected to a physical activity protocol, consisting of 30 min forced treadmill exercise for 5 consecutive days per week during 10 months. Baseline and sedentary (non-exercised) rats were used as controls. Lipids, oxidized low-density lipoprotein cholesterol, nitric oxide metabolites, and pro- and anti-inflammatory markers were measured in blood collected upon euthanasia. Results At variance to young baseline control rats, 14-month-old animals fed normal diet had increased plasma lipid levels, including total cholesterol and triglycerides, which were further elevated in rats that consumed a high-fat diet. While treadmill exercise did not lower the amount of serum lipids in standard diet group, forced physical activity reduced non-high-density lipoprotein cholesterol in response to high-fat diet feeding. Exercised rats fed standard diet or high-fat diet had lower abundancy of nitric oxide metabolites, which coincided with increased levels of oxidized low-density lipoprotein cholesterol. Accordingly, the amount of nitric oxide metabolites correlated inversely with oxidized low-density lipoprotein cholesterol and homo-arginine. Exercise significantly reduced inflammatory cytokines in high-fat diet fed rats only. Conclusion Our study suggests that regular exercise alters the equilibrium between oxidative and anti-oxidative compounds and reduces pro-inflammatory cytokines.

scholarly journals Data mining: Traditional Spring Festival Associated With Hypercholesterolemia

2021 ◽  
Author(s):  
Danchen Wang ◽  
Yutong Zou ◽  
Honglei Li ◽  
Songlin Yu ◽  
Liangyu Xia ◽  
...  
Keyword(s):  
Information System ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
High Fat ◽  
College Hospital ◽  
Cross Sectional ◽  
Spring Festival ◽  
High Fat Diets ◽  
Fat Diets

Abstract BackgroundSerum lipid concentrations are affected by long-term high fat diets; thus, we hypothesise that lipid levels increase after Spring Festival in China. In total, 20,192 individuals (males, 10,108; females, 10,084) were enrolled in this retrospective cross-sectional study, based on clinical data from Laboratory Information System (LIS) and Hospital Information System (HIS) in Peking Union Medical College Hospital, from 2014 to 2018. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were analysed. Results Average age, BMI, SBP, and DBP of the participants were 39.4 years, 23.7 kg/m2, 118 mmHg, and 73 mmHg, respectively. Serum TC, TG, and LDL levels were significantly higher in males than in females (P < 0.001); serum HDL-C was statistically lower in males (P < 0.001). In February, the TC, TG, and LDL-C levels were 8.4%, 16.3%, and 9.3% higher than the lowest levels recorded, respectively. Additionally, dyslipidaemia prevalence was statistically higher in the first week after Spring Festival than in May–January. Conclusion Higher TC, TG, LDL-C in winter could be associated with high fat diets during Spring Festival. Spring Festival was immediately followed by a higher lipid concentration. Thus, it is necessary accurately diagnose dyslipidaemia after Spring Festival.

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