Aberrant Functional Connectivity of Basal Forebrain Subregions with Cholinergic System in Short-term and Chronic Insomnia Disorder

2021 ◽  
Vol 278 ◽  
pp. 481-487
Author(s):  
Xiaofen Ma ◽  
Shishun Fu ◽  
Yi Yin ◽  
Yunfan Wu ◽  
Tianyue Wang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Basal Forebrain ◽  
Cholinergic System ◽  
Chronic Insomnia ◽  
Short Term ◽  
Insomnia Disorder

scholarly journals The Abnormal Functional Connectivity in the Locus Coeruleus-Norepinephrine System Associated With Anxiety Symptom in Chronic Insomnia Disorder

2021 ◽  
Vol 15 ◽  
Author(s):  
Liang Gong ◽  
Min Shi ◽  
Jian Wang ◽  
Ronghua Xu ◽  
Siyi Yu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Locus Coeruleus ◽  
Inferior Frontal Gyrus ◽  
Underlying Mechanism ◽  
Anxiety Symptoms ◽  
Anterior Cingulate ◽  
Functional Network ◽  
Chronic Insomnia ◽  
Dorsal Anterior Cingulate Cortex ◽  
Insomnia Disorder

BackgroundMental syndromes such as anxiety and depression are common comorbidities in patients with chronic insomnia disorder (CID). The locus coeruleus noradrenergic (LC-NE) system is considered to be crucial for modulation of emotion and sleep/wake cycle. LC-NE system is also a critical mediator of the stress-induced anxiety. However, whether the LC-NE system contributes to the underlying mechanism linking insomnia and these comorbidities remain unclear. This study aimed to investigate the LC-NE system alterations in patients with insomnia and its relationship with depression and anxiety symptoms.Materials and MethodsSeventy patients with CID and 63 matched good sleep control (GSC) subjects were recruited and underwent resting-state functional MRI scan. LC-NE functional network was constructed by using seed-based functional connectivity (FC) analysis. The alterations in LC-NE FC network in patients with CID and their clinical significance was explored.ResultsCompared with GSC group, the CID group showed decreased left LC-NE FC in the left inferior frontal gyrus, while they had increased LC-NE FC in the left supramarginal gyrus and the left middle occipital gyrus (MOG). For the right LC-NE FC network, decreased FC was found in left dorsal anterior cingulate cortex (dACC). Interesting, the increased LC-NE FC was located in sensory cortex, while decreased LC-NE FC was located in frontal control cortex. In addition, the FC between the left LC and left MOG was associated with the duration of the disease, while abnormal FC between right LC and left dACC was associated with the anxiety scores in patients with CID.ConclusionThe present study found abnormal LC-NE functional network in patients with CID, and the altered LC-NE function in dACC was associated with anxiety symptoms in CID. The present study substantially extended our understanding of the neuropathological basis of CID and provided the potential treatment target for CID patients who also had anxiety.

scholarly journals Synaptic co-transmission of acetylcholine and GABA regulates hippocampal states

2017 ◽  
Author(s):  
Virág T. Takács ◽  
Csaba Cserép ◽  
Dániel Schlingloff ◽  
Balázs Pósfai ◽  
András Szőnyi ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Neurodegenerative Disorders ◽  
Basal Forebrain ◽  
Cholinergic System ◽  
Epileptiform Activity ◽  
Short Term ◽  
Main Text ◽  
Short Term Plasticity ◽  
Synaptic Control ◽  
Novel Model

SummaryThe basal forebrain cholinergic system is widely assumed to control cortical functions via non-synaptic transmission of a single neurotransmitter, acetylcholine. Yet, using immune-electron tomographic, molecular anatomical, optogenetic and physiological techniques, we find that mouse hippocampal cholinergic terminals invariably establish synapses and their vesicles dock at synapses only. We demonstrate that these synapses do not co-release but co-transmit GABA and acetylcholine via different vesicles, whose release is triggered by distinct calcium channels. This co-transmission evokes fast composite postsynaptic potentials, which are mutually cross-regulated by presynaptic auto-receptors and display different short-term plasticity. The GABAergic component alone effectively suppresses hippocampal sharp wave-ripples and epileptiform activity. The synaptic nature of the forebrain cholinergic system with differentially regulated, fast, GABAergic and cholinergic co-transmission suggests a hitherto unrecognized level of synaptic control over cortical states. This novel model of hippocampal cholinergic neurotransmission could form the basis for alternative pharmacotherapies after cholinergic deinnervation seen in neurodegenerative disorders.Supplementary materials are attached after the main text.

scholarly journals Acupuncture Treatment Modulates the Hypothalamus Functional Connectivity in Patients With Chronic Insomnia Disorder

2021 ◽  
Vol 168 ◽  
pp. S135
Author(s):  
Siyi Yu ◽  
Wei Peng ◽  
Leixiao Zhang ◽  
Jie Yang ◽  
Youping Hu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Acupuncture Treatment ◽  
Chronic Insomnia ◽  
Insomnia Disorder

Convergent and divergent functional connectivityalterations of hippocampal subregions between short-term and chronic insomnia disorder

2020 ◽  
Author(s):  
Xiaofen Ma ◽  
Guihua Jiang ◽  
Junzhang Tian ◽  
Mengchen Liu ◽  
Jin Fang ◽  
...  
Keyword(s):  
Chronic Insomnia ◽  
Short Term ◽  
Insomnia Disorder

scholarly journals Disrupted interhemispheric functional connectivity in chronic insomnia disorder: a resting-state fMRI study

2018 ◽  
Vol Volume 14 ◽  
pp. 1229-1240 ◽  
Author(s):  
Fuqing Zhou ◽  
Yanlin Zhao ◽  
Muhua Huang ◽  
Xianjun Zeng ◽  
Bo Wang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Resting State Fmri ◽  
Chronic Insomnia ◽  
Insomnia Disorder ◽  
Fmri Study

Selective Immunolesioning of the Basal Forebrain Cholinergic System Disrupts Short-term Memory in Rats

1996 ◽  
Vol 8 (7) ◽  
pp. 1535-1544 ◽  
Author(s):  
G. Leanza ◽  
J. Muir ◽  
O. G. Nilsson ◽  
R. G. Wiley ◽  
S. B. Dunnett ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Cholinergic System ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory
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