Sex differences in the associations of nonmedical use of prescription drugs with self-injurious thoughts and behaviors among adolescents: A large-scale study in China

2021 ◽  
Vol 285 ◽  
pp. 29-36
Author(s):  
Bo Xie ◽  
Beifang Fan ◽  
Wanxin Wang ◽  
Wenyan Li ◽  
Ciyong Lu ◽  
...  
Keyword(s):  
Sex Differences ◽  
Prescription Drugs ◽  
Large Scale ◽  
Large Scale Study ◽  
Nonmedical Use ◽  
And Behaviors

scholarly journals Problematic Internet Use, Non-Medical Use of Prescription Drugs, and Depressive Symptoms among Adolescents: A Large-Scale Study in China

2020 ◽  
Vol 17 (3) ◽  
pp. 774
Author(s):  
Beifang Fan ◽  
Wanxing Wang ◽  
Tian Wang ◽  
Bo Xie ◽  
Huimin Zhang ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Prescription Drugs ◽  
Large Scale ◽  
Internet Use ◽  
Chinese Adolescents ◽  
Problematic Internet Use ◽  
Large Scale Study ◽  
Frequent Use ◽  
Increased Risk ◽  
Path Models

This large-scale study aimed to test, among Chinese adolescents, the association between problematic Internet use (PIU), non-medical use of prescription drugs (NMUPD), and depressive symptoms, as well as the mediating effects of NMUPD on the associations above. This study used the data from the 2017 National School-based Chinese Adolescents Health Survey, and 24,345 students’ questionnaires qualified for the analyses. Generalized linear mixed models and path models were performed. In the models without mediation, PIU was associated with depressive symptoms (unstandardized β estimate = 0.26, 95% CI = 0.25–0.27); frequent use of opioid or sedative was also related to depressive symptoms (unstandardized β estimate for opioid = 2.77, 95% CI = 1.90–3.63; unstandardized β estimate for sedative = 4.45, 95% CI = 3.02–5.88). Additionally, the results of the path models indicated that opioid misuse partially mediated the association between PIU and depressive symptoms. PIU and opioid/sedative misuse were related to the increased risk of depressive symptoms, respectively. The association above might be complicated, and PIU may elevate the risk of opioid or sedative misuse and depressive symptoms, which in turn could worsen the situation of PIU and vice versa. Multidisciplinary health intervention programs to prevent adolescents involving in PIU, as well as NMPUD, are recommended to be provided.

Association between nonmedical use of opioids or sedatives and suicidal behavior among Chinese adolescents: An analysis of sex differences

2018 ◽  
Vol 53 (6) ◽  
pp. 559-569 ◽  
Author(s):  
Lan Guo ◽  
Min Luo ◽  
Wanxin Wang ◽  
Di Xiao ◽  
Chuhao Xi ◽  
...  
Keyword(s):  
Sex Differences ◽  
Suicidal Ideation ◽  
Confidence Interval ◽  
Suicidal Behavior ◽  
Prescription Drugs ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Suicide Attempts ◽  
Frequent Use ◽  
Nonmedical Use

Objective: The rising rate of suicidal behavior among adolescents is a growing concern, and sex differences may induce differential exposure to prescription drug misuse or suicidal behavior. We estimated, among Chinese adolescents, (1) the prevalence of nonmedical use of prescription drugs, suicidal ideation and suicide attempts; (2) whether nonmedical use of prescription drugs was independently associated with suicidal ideation and suicide attempts; and (3) whether there were sex differences in the associations. Methods: This was a secondary analysis of the data drawn from the 2015 National School-based Chinese Adolescents Health Survey. A total of 94,911 students completed questionnaires and qualified for our survey (response rate: 93.7%). All analyses were conducted separately for boys and girls. Results: There were significant sex differences in the prevalence of opioid or sedative misuse, and the sources and reasons for nonmedical use of prescription drugs ( p < 0.05). The prevalence of suicidal ideation or suicide attempts was significantly higher in girls than in boys (suicidal ideation: 17.9% among girls vs 14.1% among boys; suicide attempts: 3.5% among girls vs 2.7% among boys). Among girls, frequent use of opioids was associated with an increased risk of suicidal ideation (adjusted odds ratio = 1.84, 95% confidence interval = [1.57, 2.17]) and suicide attempts (adjusted odds ratio = 2.96, 95% confidence interval = [2.34, 3.74]), and frequent use of sedatives was also positively associated with suicidal ideation (adjusted odds ratio = 2.23, 95% confidence interval = [1.91, 2.60]) and suicide attempts (adjusted odds ratio = 4.02, 95% confidence interval = [3.25, 4.99]). These associations were also statistically significant in boys, but the magnitudes of adjusted odds ratios for the associations between frequent use of opioids and sedatives and suicidal behavior were greater in girls than boys. Conclusion: There exist significant sex differences in the prevalence rates of nonmedical use of prescription drugs and suicidal behavior, and the child’s sex plays a role in the association between nonmedical use of prescription drugs and suicidal behavior. The significant sex differences found above may provide a basis for early identification of adolescents at high risk of suicidal behavior.

The Nonmedical Use of Prescription Drugs in the United States

1993 ◽  
Author(s):  
Edgar H. Adams ◽  
◽  
Andrea N. Kopstein
Keyword(s):  
United States ◽  
Prescription Drugs ◽  
The United States ◽  
Nonmedical Use

Nonmedical Use of Prescription Drugs Among Pregnant Women

2007 ◽  
Author(s):  
Jennifer R. Havens ◽  
William W. Stoops ◽  
Lisa Shannon
Keyword(s):  
Pregnant Women ◽  
Prescription Drugs ◽  
Nonmedical Use

Exploring Temporal Reduction in Dialectal Spanish: A Large-scale Study of Lenition of Voiced Stops and Coda-s

2018 ◽  
Author(s):  
Ioana Vasilescu ◽  
Nidia Hernandez ◽  
Bianca Vieru ◽  
Lori Lamel
Keyword(s):  
Large Scale ◽  
Large Scale Study

scholarly journals Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

2019 ◽  
Vol 79 ◽  
pp. 152-158 ◽  
Author(s):  
Kristoffer Sølvsten Burgdorf ◽  
Betina B. Trabjerg ◽  
Marianne Giørtz Pedersen ◽  
Janna Nissen ◽  
Karina Banasik ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Large Scale ◽  
Large Scale Study

scholarly journals Correction to: Methane and Electricity Production from Poultry Litter Digestion in the Amazon Region of Brazil: A Large-Scale Study

2021 ◽  
Author(s):  
Marcelo Mendes Pedroza ◽  
Wanderson Gomes da Silva ◽  
Luciene Santos de Carvalho ◽  
Alice Rocha de Souza ◽  
Girlene Figueiredo Maciel
Keyword(s):  
Large Scale ◽  
Poultry Litter ◽  
Amazon Region ◽  
Electricity Production ◽  
Large Scale Study

scholarly journals First Detection of SARS-CoV-2 B.1.1.7 Variant of Concern in an Asymptomatic Dog in Spain

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1379
Author(s):  
Sandra Barroso-Arévalo ◽  
Belén Rivera ◽  
Lucas Domínguez ◽  
José M. Sánchez-Vizcaíno
Keyword(s):  
Active Surveillance ◽  
Large Scale ◽  
Infectious Virus ◽  
Viral Isolation ◽  
Viral Loads ◽  
Large Scale Study ◽  
Rectal Swabs

Natural SARS-CoV-2 infection in pets has been widely documented during the last year. Although the majority of reports suggested that dogs’ susceptibility to the infection is low, little is known about viral pathogenicity and transmissibility in the case of variants of concern, such as B.1.1.7 in this species. Here, as part of a large-scale study on SARS-CoV-2 prevalence in pets in Spain, we have detected the B.1.1.7 variant of concern (VOC) in a dog whose owners were infected with SARS-CoV-2. The animal did not present any symptoms, but viral loads were high in the nasal and rectal swabs. In addition, viral isolation was possible from both swabs, demonstrating that the dog was shedding infectious virus. Seroconversion occurred 23 days after the first sampling. This study documents the first detection of B.1.1.7 VOC in a dog in Spain and emphasizes the importance of performing active surveillance and genomic investigation on infected animals.

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