Negative life stress, sleep disturbance, and depressive symptoms: the moderating role of anterior insula activity in response to sleep-related stimuli

Author(s):  
Sun-Young Kim ◽  
Kyung Hwa Lee ◽  
Hayoung Lee ◽  
Jeong Eun Jeon ◽  
Mi Hyun Lee ◽  
...  
2021 ◽  
pp. 000486742110257
Author(s):  
Kyung Hwa Lee ◽  
Ha Young Lee ◽  
Inkyung Park ◽  
Jeong Eun Jeon ◽  
Nambeom Kim ◽  
...  

Objectives: Evidence suggests that emotion regulation difficulty may play an important role in the association between life stress, sleep disturbance and depressive symptoms. We proposed two models depicting the possible moderating roles of prefrontal cortex activation during emotion regulation in the associations among these variables and tested them. We hypothesized that (1) the association between stress and sleep disturbance would differ across prefrontal cortex activation during emotion regulation (moderation model) and (2) the indirect effects of stress on depressive symptoms through sleep disturbance would depend on prefrontal cortex activation during emotion regulation (moderated mediation model). Methods: Forty-eight healthy adults without sleep disorders based on nocturnal polysomnography participated in this study. They received functional magnetic resonance imaging scans while performing an emotion regulation task. They also completed questionnaires assessing life stress, sleep disturbance and depressive symptoms. The proposed models were tested using the PROCESS macro for SPSS. Results: As hypothesized, there was a significant moderating effect of prefrontal cortex activation during emotion regulation on the association between life stress and sleep disturbance. Furthermore, right lateral prefrontal cortex activation had a moderating role in the indirect effect of life stress on depressive symptoms through sleep disturbance. Conclusion: These findings highlight the important role of prefrontal cortex function during emotion regulation in the associations between stress, sleep disturbance and depressive symptoms. Increasing lateral prefrontal cortex recruitment when regulating the emotional response to negative life events may be critical for the prevention and intervention of depression as well as sleep problems.


2016 ◽  
Vol 29 (7) ◽  
pp. 1251-1267 ◽  
Author(s):  
Jeong Eun Lee ◽  
Lynn M. Martire ◽  
Steve H. Zarit ◽  
Michael J. Rovine

Objective: The present study aimed to clarify the circumstances under which activity restriction (AR) is associated with depressive symptoms among patients with osteoarthritis (OA) and their spouses. Method: A total of 220 older adults with OA and their caregiving spouses participated in the study. The actor–partner interdependence model (APIM) was used to examine the associations between AR stemming from patients’ OA and the depressive symptoms of patients and spouses. The potential moderating role of marital satisfaction also was examined. Results: After accounting for pain severity, health, and life stress of both patients with OA and spouses, higher AR was associated with more depressive symptoms for both patients and spouses. In regard to partner effects, patients whose spouse had higher AR reported more depressive symptoms. In addition, the association of spouses’ and patients’ AR and their own depressive symptoms was moderated by their marital satisfaction. For both patients and spouses, the associations between their own AR and depressive symptoms were weaker for those with higher levels of marital satisfaction compared with those with lower levels of marital satisfaction. Discussion: This pattern of findings highlights the dyadic implications of AR and the vital role of marital satisfaction in the context of chronic illness.


2019 ◽  
Vol 22 (11) ◽  
pp. 692-699 ◽  
Author(s):  
David A. Cole ◽  
Elizabeth A. Nick ◽  
Gergely Varga ◽  
Darcy Smith ◽  
Rachel L. Zelkowitz ◽  
...  

Author(s):  
Sae Hwang Han ◽  
Kyungmin Kim ◽  
Jeffrey A Burr

Abstract Objectives Limitations in performing basic daily activities, as well as spousal caregiving that arises from activity limitations, are important factors that have ramifications for mental health among couples. The objective of this study was to investigate the interplay of these factors by focusing on whether the associations between activity limitations and depressive symptoms among coupled-individuals were moderated by receipt and provision of spousal care. Methods Longitudinal household data from the Health and Retirement Study (2004–2014; dyad N = 6,614) were analyzed to estimate within-person associations between one’s own and spousal activity limitations, receipt and provision of spousal care, and depressive symptoms. Results Findings showed a consistent link between one’s own activity limitations and depressive symptoms for both spouses, whereas spousal activity limitations were associated with depressive symptoms for wives only. We also found moderating effects of spousal care in the link between one’s own and spousal activity limitations and depressive symptoms. Discussion Receipt and provision of activities of daily living-related assistance may contextualize the association between activity limitations and depressive symptoms among older coupled-individuals in a direction that could alleviate or aggravate the risk of depression.


2014 ◽  
Vol 49 ◽  
pp. 90-95 ◽  
Author(s):  
Scott M. Monroe ◽  
George M. Slavich ◽  
Ian H. Gotlib

2018 ◽  
Vol 27 (12) ◽  
pp. 3964-3974 ◽  
Author(s):  
Lindsey M. Green ◽  
Lies Missotten ◽  
Erin B. Tone ◽  
Koen Luyckx

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