Delusional Depression in Late-Life: Treatment Effects on Mood, Psychosis, Cognition and the Brain

2014 ◽  
Vol 22 (3) ◽  
pp. S10
Author(s):  
Barnett S. Meyers ◽  
Benoit H. Mulsant ◽  
Ellen Whyte
Keyword(s):  
Treatment Effects ◽  
Late Life ◽  
Delusional Depression ◽  
The Brain

Late-Life Delusional Depression: Acute and Long-Term Treatment

1995 ◽  
Vol 7 (S1) ◽  
pp. 113-124 ◽  
Author(s):  
Barnett S. Meyers
Keyword(s):  
Elderly Patients ◽  
Late Life ◽  
Poor Response ◽  
Term Treatment ◽  
Delusional Depression ◽  
Increased Risk ◽  
Long Term Treatment ◽  
Medication Side ◽  
Continuation Treatment ◽  
High Doses

Treatment studies of delusional major depression demonstrate a poor response to standard antidepressant medications. Longitudinal studies demonstrate high relapse rates, even in patients receiving postdischarge antidepressants. The poor medical and psychiatric outcomes for late-life delusional depression and the increased risk for adverse medication reactions in this population underscore the importance of developing effective postrecovery treatments.Studies of mixed-age adults demonstrate the effectiveness of acute treatment with either electroconvulsive therapy or combination pharmacotherapy with high doses of neuroleptics and antidepressants. In considering these results in relation to the treatment of late-life delusional depression, attention must be given to the particular vulnerabilities to medication side effects of elderly patients.The potential effectiveness of continuation treatment with combined antidepressant-neuroleptic therapy is discussed. Clinical and methodologic issues related to studying the effectiveness of combination treatment in elderly patients are emphasized.

scholarly journals Joint effect of mid- and late-life blood pressure on the brain: The AGES-Reykjavik Study

Neurology ◽  
2014 ◽  
Vol 82 (24) ◽  
pp. 2187-2195 ◽  
Author(s):  
M. Muller ◽  
S. Sigurdsson ◽  
O. Kjartansson ◽  
T. Aspelund ◽  
O. L. Lopez ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Late Life ◽  
Joint Effect ◽  
The Brain

Late-life delusional depression

1986 ◽  
Vol 11 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Barnett S. Meyers ◽  
Robert Greenberg
Keyword(s):  
Late Life ◽  
Delusional Depression

Multi-modal MRI classifiers identify excessive alcohol consumption and treatment effects in the brain

2016 ◽  
Vol 22 (5) ◽  
pp. 1459-1472 ◽  
Author(s):  
Alejandro Cosa ◽  
Andrea Moreno ◽  
Jesús Pacheco-Torres ◽  
Roberto Ciccocioppo ◽  
Petri Hyytiä ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Treatment Effects ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol ◽  
The Brain

Allelic Differences in the Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Late-Life Depression

2007 ◽  
Vol 15 (10) ◽  
pp. 850-857 ◽  
Author(s):  
Warren D. Taylor ◽  
Stephan Züchner ◽  
Douglas R. McQuoid ◽  
David C. Steffens ◽  
Marcy C. Speer ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Late Life ◽  
Brain Derived Neurotrophic Factor ◽  
Late Life Depression ◽  
Val66met Polymorphism ◽  
Allelic Differences ◽  
The Brain

Delusional and Non-delusional Depression in Late Life

1988 ◽  
Vol 152 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Robert C. Baldwin
Keyword(s):  
Depressive Symptoms ◽  
Poor Prognosis ◽  
Clinical Course ◽  
Late Onset ◽  
Late Life ◽  
Younger Patients ◽  
Delusional Depression ◽  
Discharge Status ◽  
Physical Treatments ◽  
Relapse Rates

The study tests the hypothesis that delusional and non-delusional depressive illnesses are distinct entities in late life. Two groups of 24 patients with late-onset depression, one with and one without delusions, were compared retrospectively. At the index admission, deluded patients were significantly more depressed, were in hospital for longer, responded poorly to antidepressants alone and required more physical treatments, especially ECT and major tranquillisers. Although illness severity was a major factor accounting for these differences, the finding that only the deluded group experienced delusional relapses suggests an underlying intrinsic susceptibility. The discharge status was similar for both groups, as were relapse rates over 48 months and the clinical course of depressive symptoms over 42–104 months. The findings are consistent with studies of younger patients which point to a distinction between these two types of depression, but not with recent work suggesting a very poor prognosis for delusional depression in late life.

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