Electroconvulsive therapy is most often used to treat disorders of mood. The internally experienced feeling is the emotional state reflected in the way we present ourselves to others and in the ways we react to them. Mood varies with daily circumstances and is sensitive to the conditions of the body, particularly physical health, fatigue, hunger, and hormonal activity. Moods are experienced internally and fluctuate widely. Two disorders are recognized. Depression, or depressive mood disorder, is dominated by sadness, hopelessness, fear of the future, and the persistent thought that life is not worth living. Mania, or manic mood disorder, is a state of excitement, grandiosity, expansiveness, and feelings of increased power and energy. In the present psychiatric classification, mania is labeled bipolar disorder and the depressed phase is labeled major depression. In a depressive mood disorder, body functions are disrupted. Patients are sleepless, appetite is poor, and weight loss may be pronounced, at times amounting to 20% of the body weight within a few weeks. Work, sexual activity, and family may be disregarded. The future appears hopeless, patients believe they are helpless to affect it, and their thoughts are filled with gloom. Threats of suicide reflect their distress. They are often agitated and restless. Many meet the criteria for the malignant syndrome of melancholia. Overwhelmed by feelings of helplessness, hopelessness, and worthlessness, the depressed patient dwells on thoughts of suicide. He may believe that others are watching or talking about him; voices are heard when no one is present; and concerns that his spouse is unfaithful dominate his thought. At times, the events depicted on the television or movie screen seem to apply directly to him. Such strange thoughts are delusions, and this severe state of depressed mood and disorder in thought is labeled delusional depression or psychotic depression. These disorders require intensive treatment and almost always hospital care. A depressed patient is commonly unaware of the day’s events, registers little of what happens around her, and has a compromised memory. This form of depression can be difficult to distinguish from an Alzheimer-type dementia. When the symptoms of dementia are brought about by depression, however, they can be reversed with treatment.