Treatment Effect of the Tree Pollen SLIT-Tablet on Allergic Rhinoconjunctivitis During Oak Pollen Season

2021 ◽  
Author(s):  
Hendrik Nolte ◽  
Susan Waserman ◽  
Anne K. Ellis ◽  
Tilo Biedermann ◽  
Peter A. Würtzen
Keyword(s):  
Treatment Effect ◽  
Pollen Season ◽  
Allergic Rhinoconjunctivitis ◽  
Tree Pollen ◽  
Oak Pollen

scholarly journals Oak pollen season in selected cities of Poland in 2019

Alergoprofil ◽  
2019 ◽  
Vol 15 (2) ◽  
pp. 12-16
Author(s):  
Katarzyna Dąbrowska-Zapart ◽  
Kazimiera Chłopek ◽  
Małgorzata Malkiewicz ◽  
Krystyna Piotrowska-Weryszko ◽  
Daniel Kotrych ◽  
...  
Keyword(s):  
Pollen Season ◽  
Oak Pollen

scholarly journals Oak pollen concentration in the air of selected Polish cities in 2020

Alergoprofil ◽  
2020 ◽  
Vol 16 (4) ◽  
pp. 15-20
Author(s):  
Anna Rapiejko ◽  
Małgorzata Malkiewicz ◽  
Monika Ziemianin ◽  
Aneta Sulborska ◽  
Kazimiera Chłopek ◽  
...  
Keyword(s):  
Pollen Season ◽  
Pollen Grains ◽  
Volumetric Method ◽  
Pollen Concentration ◽  
Total Catch ◽  
Pollen Concentrations ◽  
Oak Pollen ◽  
Annual Total ◽  
High Concentrations

The study aims to compare the oak pollen season in selected Polish cities; Bialystok, Bydgoszcz, Cracow, Katowice, Piotrkow Trybunalski, Lublin, Olsztyn, Opole, Szczecin, Warsaw, and Wroclaw in 2020. Measurements were made using the volumetric method, with a Hirst-type sampler. Oak pollen season, defined as the period with 98% of the annual total catch, started between 14 (in Opole) and 25 April (in Lublin). The season ended on 1 June at the latest;  in Sosnowiec, Bydgoszcz, Olsztyn, and Bialystok. It lasted from 30 to 47 days  (37 days on average). The maximum daily oak pollen concentrations were observed between 24 April and 11 May. The highest annual sum of oak pollen grains (SPI) was recorded in Lublin, while the lowest in Bialystok. The highest concentrations of 596 oak pollen grains/m3 were noted in Lublin on 28 April. The longest exposure to high concentrations of oak pollen (>91 grains/m3), lasting 12-13 days, was recorded in Lublin, Opole, and Wroclaw.

scholarly journals Specific subcutaneus immunotherapy by a birch extract absorbed onto calcium phosphate

2009 ◽  
Vol 7 (4) ◽  
pp. 79-84
Author(s):  
M A Mokronosova ◽  
E S Korovkina
Keyword(s):  
Calcium Phosphate ◽  
Pollen Season ◽  
Rescue Medication ◽  
Birch Pollen ◽  
Pollen Allergy ◽  
Pollen Grains ◽  
Allergic Rhinoconjunctivitis ◽  
Control Group ◽  
Common Disease ◽  
One Year

Background. Allergic rhinitis is a common disease, affecting 25-35% of the population. Birch pollen is a significant cause of immediate hypersensitivity among sensitive subjects, affecting about 80% of the population in the central part of Russian Federation. Specific subcutaneus immunotherapy (SCIT) is the only treatment producing lasting clinical improvement in patients with allergy. The aim, of the study was to investigate the efficacy of one - year SCIT for allergic rhinoconjunctivitis for birch pollen using the Average Rhinoconjunctivitis Total Symptom Score (ARTSS) and Average Rescue Medication Score (ARMS). Materials and methods. 54 subjects with IgE-mediated seasonal allergic rhinoconjunctivitis with/without seasonal asthma were enrolled; 47 patients with pollen allergy were included in a control group. All patients were sensitized to birch pollen-allergens. SCIT was performed during 9 months 2009-2010 years by a birch extract standardized in IR and absorbed onto calcium phosphate (Phostal, France). Patients were asked to complete diary during the birch pollination season (from 1 April to 1 June). Pollen grains were counted daily during the pollen seasons by standardized protocol and the amount of pollen was expressed as the number of pollen grains/m3 air. The ARTSS was derived from individual symptom scores for nasal and eye symptoms during the pollen season. In addition there was a daily score for the use of rescue medication (ARMS). Rescue medication allowed included Hl-antihistamines, nasal steroids, oral steroids; each puff, drop (nostril/eye), tablet counted as one point. Results. The seasonal pollen counts and the duration of the pollen season had differed in 2009 and in 2010. Reduction in ARTSS of 29% and decrease in ARMS of 28,9% were found in the birch pollen season for subjects treated with the SCIT compared with controls after one year of treatment. The immunotherapy after the end of the treatment was not effective in 3 patients (5%). Conclusion. Immunotherapy by Phostal shows clinical effect on development of seasonal rhinoconjunctivitis. The decrease in ARTSS for Phostal-treated patients that occurred in parallel with a marked reduction in their requirement for ARMS provides additional evidence for the efficacy of SCIT over and above usual pharmacotherapy for rhinitis.

Dose escalation using carbamylated monomeric tree pollen drops is well tolerated in patients with allergic rhinoconjunctivitis and points towards clinical effects

Allergy ◽  
2019 ◽  
Vol 74 (11) ◽  
pp. 2273-2276
Author(s):  
Esther Raskopf ◽  
Silke Allekotte ◽  
Enrico Compalati ◽  
Jaswinder Singh ◽  
Cengiz Han Acikel ◽  
...  
Keyword(s):  
Dose Escalation ◽  
Allergic Rhinoconjunctivitis ◽  
Clinical Effects ◽  
Tree Pollen

СРАВНИТЕЛЬНАЯ ЭФФЕКТИВНОСТЬ РАЗНЫХ МЕТОДОВ АЛЛЕРГЕН-СПЕЦИФИЧЕСКОЙ ИММУНОТЕРАПИИ У ПАЦИЕНТОВ С ПОЛЛИНОЗОМ: ОТКРЫТОЕ РАНДОМИЗИРОВАННОЕ ИСПЫТАНИЕ

2019 ◽  
pp. 35-45
Author(s):  
A.Y. Nasunova ◽  
N.M. Nenasheva
Keyword(s):  
Pollen Season ◽  
Biological Fluids ◽  
Clinical Manifestations ◽  
Allergic Rhinoconjunctivitis ◽  
Nasal Lavage ◽  
Subcutaneous Immunotherapy ◽  
Immune Reactivity ◽  
Cationic Protein ◽  
New Findings ◽  
Study Results

Аллергенспецифическая иммунотерапия (АСИТ) является единственным методом, способным влиять на все патогенетически значимые звенья аллергического процесса, на раннюю и позднюю фазы IgEопосредованной аллергической реакции и тем самым видоизменять характер иммунного ответа организма на аллерген. В настоящее время в клинической практике наиболее часто используют подкожный (ПКИТ) и сублингвальный методы (СЛИТ) АСИТ. Несмотря на доказанную эффективность подкожной и сублингвальной аллергенспецифической иммунотерапии, остаются нерешенными вопросы предпочтительного метода сравнительной эффективности АСИТ посредством измерения биомаркеров в сыворотке крови и в других биологических жидкостях у пациентов с аллергическим ринитом (с/без астмы). Цель. Провести сравнительный анализ эффективности разных методов АСИТ (ПКИТ и СЛИТ экстрактами аллергенов) на основании клинических и иммунологических параметров. Материалы и методы. В исследование включены 60 пациентов с аллергическим ринитом (с/без астмы) в возрасте от 18 до 50 лет. Все пациенты случайным способом были распределены на 3 группы в зависимости от метода проведения АСИТ: группа 1 пациенты, получавшие сублингвальную АСИТ экстрактами аллергенов группа 2 пациенты, получавшие подкожную АСИТ экстрактами аллергенов группа 3 пациенты, получавшие подкожную АСИТ модифицированными аллергенами (аллергоидами). Результаты. Продемонстрирована эффективность предсезонной АСИТ (ПКИТ и СЛИТ) экстрактами аллергенов и аллергоидами в контроле симптомов аллергического риноконъюнктивита (с/без астмы). Анализ данных шкал (Total Symptom Scove TSS, Mediacation Scove MS) после окончания 1го курса предсезонной АСИТ выявил статистически значимые различия между группами пациентов, получавших ПКИТ аллергоидами, и пациентами, получавшими СЛИТ аллергенами: по шкалам TSS (р0,023), MS (р0,002). Кроме того, у пациентов, получавших ПКИТ аллергоидами, к концу поддерживающей фазы АСИТ уровень эозинофильного катионного протеина (ECP) в назальном лаваже снизился на 22 (p0,012), секреторного иммуноглобулина А (sIgA) в назальном лаваже увеличился на 70 (p0,001), интерлейкина10 (ИЛ10) в сыворотке крови увеличился на 126 (p0,006), аллергенспецифического IgG4 увеличился на 42 (p0,01) от исходных значений, что коррелирует с уменьшением выраженности клинических проявлений. В сезон естественной экспозиции аллергенов уровень ECP в назальном лаваже статистически значимо (p0,007) ниже в группе больных, получавших ПКИТ аллергоидами, по сравнению со СЛИТ аллергенами. Статистически значимо более высокие показатели сывороточного уровня ИЛ10 в сезон цветения также отмечены в группе больных, получавших ПКИТ аллергоидами, по сравнению с группами, получавшими СЛИТ (p0,013) и ПКИТ (p0,001) экстрактами аллергенов. Заключение. Результаты исследования углубляют имеющиеся представления о механизмах ПКИТ и СЛИТ. Они позволяют разработать схему комплексной оценки эффективности данной терапии, базирующейся на мониторинге клинических параметров, а также локальных (ECP, sIgA) и системных биомаркеров (ИЛ10, аллергенспецифический IgG4).Background. Allergenspecific immunotherapy (ASIT) is viewed as the only treatment that influences all pathogenetically significant parts of the allergic process in the initial and late phases of the IgEmediated allergic reaction and modifies the abnormal immune reactivity to a specific allergen. Currently, sublingual (SLIT) and subcutaneous (SCIT) immunotherapy are most commonly used in clinical practice. Despite long experience of sublingual and subcutaneous immunotherapy application, questions remain about the preferred ASIT method and comparative effectiveness of different ASIT methods. This article evaluates the efficacy, benefits of SCIT and SLIT and highlights new findings related mechanisms and potential biomarkers. The aim of the study. To evaluate the comparative efficacy of different methods of ASIT (subcutaneous and sublingual) based on clinical data and biomarkers in the blood serum and other biological fluids in adult patients with allergic rhinoconjunctivitis (with/without asthma). Materials and methods. 60 patients with allergic rhinoconjunctivitis (with/without asthma) aged 18 to 50 were randomly assigned to 3 groups treated by sublingual immunotherapy with extracts of allergens, subcutaneous immunotherapy with extracts of allergens and subcutaneous with modified allergens (allergoids) respectively. Results. The efficiency of the first course of preseason ASIT (SCIT and SLIT) with extracts of allergens and allergoids in the control of symptoms of allergic rhinoconjunctivitis (with/without asthma) was demonstrated. After the end of the first year preseason ASIT data analysis scales (Total Symptom Score TSS, Medircation Score MS) revealed the best performance in the group of patients receiving SCIT with allergoids compared with patients receiving the SLIT with extracts of allergens: the scales of the TSS (p0.023), MS (p0.002). In addition, at the end of the maintenance phase of ASIT in patients treated with SCIT with allergoids the level of eosinophilic cationic protein (ECP) in the nasal lavage decreased by 22 (p0.012), secretory immunoglobulin A (sIgA) in the nasal lavage increased by 70 (p0.001), interleukin10 (IL10) in serum increased by 126 (p0.006), allergenspecific IgG4 increased by 42 (p0.01) from the initial values, that correlates with a decrease in the severity of clinical manifestations. In pollen season ECP level in nasal lavage was significantly (p0.007) lower in a group of patients who received SCIT with allergoids compared with patients who received the SLIT with extracts of allergens. The most significant changes of serum level of IL10 in the pollen season occurred in a group of patients receiving SCIT with allergoids compared with patients who received SLIT (p0.013) and SCIT (p0.001) with extracts of allergens. Conclusion. The study results deepen the existing understanding of the mechanisms of SCIT and SLIT. They allow to develop a comprehensive assessment of the therapy efficacy scheme based on clinical parameters and on monitoring of local (ECP, sIgA) and systemic biomarkers (IL10, allergenspecific IgG4) as well.

scholarly journals A comparison of different methods of the allergen-specific immunotherapy in patients with pollinosis: the results of open randomized study

2019 ◽  
Vol 16 (3) ◽  
pp. 35-45
Author(s):  
A Y Nasunova ◽  
N M Nenasheva
Keyword(s):  
Pollen Season ◽  
Specific Immunotherapy ◽  
Allergic Rhinoconjunctivitis ◽  
Nasal Lavage ◽  
Subcutaneous Immunotherapy ◽  
Immune Reactivity ◽  
Allergen Specific Immunotherapy ◽  
New Findings ◽  
Study Results ◽  
Specific Igg4

Background. Allergen-specific immunotherapy (ASIT) is viewed as the only treatment that influences all patho-genetically significant parts of the allergic process in the initial and late phases of the IgE-mediated allergic reaction and modifies the abnormal immune reactivity to a specific allergen. Currently, sublingual (SLIT) and subcutaneous (SCIT) immunotherapy are most commonly used in clinical practice. Despite long experience of sublingual and subcutaneous immunotherapy application, questions remain about the preferred ASIT method and comparative effectiveness of different ASIT methods. This article evaluates the efficacy, benefits of SCIT and SLIT and highlights new findings related mechanisms and potential biomarkers. The aim of the study. To evaluate the comparative efficacy of different methods of ASIT (subcutaneous and sublingual) based on clinical data and biomarkers in the blood serum and other biological fluids in adult patients with allergic rhinoconjunctivitis (with/without asthma). Materials and methods. 60 patients with allergic rhinoconjunctivitis (with/without asthma) aged 18 to 50 were randomly assigned to 3 groups treated by sublingual immunotherapy with extracts of allergens, subcutaneous immunotherapy with extracts of allergens and subcutaneous with modified allergens (allergoids) respectively. Results. The efficiency of the first course of preseason ASIT (SCIT and SLIT) with extracts of allergens and aller-goids in the control of symptoms of allergic rhinoconjunctivitis (with/without asthma) was demonstrated. After the end of the first year pre-season ASIT data analysis scales (Total Symptom Score -TSS, Medircation Score -MS) revealed the best performance in the group of patients receiving SCIT with allergoids compared with patients receiving the SLIT with extracts of allergens: the scales of the TSS (p=0.023), MS (p=0.002). In addition, at the end of the maintenance phase of ASIT in patients treated with SCIT with allergoids the level of eosinophilic cationic protein (ECP) in the nasal lavage decreased by 22% (p=0.012), secretory immunoglobulin A (sIgA) in the nasal lavage increased by 70% (p=0.001), interleukin-10 (IL-10) in serum increased by 126% (p=0.006), allergen-specific IgG4 increased by 42% (p=0.01) from the initial values, that correlates with a decrease in the severity of clinical manifestations. In pollen season ECP level in nasal lavage was significantly (p=0.007) lower in a group of patients who received SCIT with allergoids compared with patients who received the SLIT with extracts of allergens. The most significant changes of serum level of IL-10 in the pollen season occurred in a group of patients receiving SCIT with allergoids compared with patients who received SLIT (p=0.013) and SCIT (p=0.001) with extracts of allergens. Conclusion. The study results deepen the existing understanding of the mechanisms of SCIT and SLIT. They allow to develop a comprehensive assessment of the therapy efficacy scheme based on clinical parameters and on monitoring of local (ECP, sIgA) and systemic biomarkers (IL-10, allergen-specific IgG4) as well.

scholarly journals Plane tree pollen season in Poland and Hungary in 2019 – why are the plane trees planted in cities so much?

Alergoprofil ◽  
2020 ◽  
Vol 16 (1) ◽  
pp. 15-20
Author(s):  
Małgorzata Puc ◽  
Donát Magyar ◽  
Orsolya Udvardy ◽  
Agnieszka Lipiec ◽  
Piotr Rapiejko ◽  
...  
Keyword(s):  
Pollen Season ◽  
Pollen Allergy ◽  
Pollen Grains ◽  
Cross Reactivity ◽  
Tree Pollen ◽  
Plane Tree ◽  
Airborne Concentration ◽  
Pollen Concentrations ◽  
Pollen Seasons ◽  
Seasonal Pollen

 Allergic diseases are considered as important human health issues as they substantially restrict many allergic people. Trees such as the plane tree can pose a certain threat to allergy sufferers. Due to the frequent planting of these trees in large cities, their pollen can affect the increase in the frequency of local allergy symptoms. This study compares the plane tree pollen seasons in Poland, in Bialystok, Bydgoszcz, Warsaw, Zielona Gora, Piotrkow Trybunalski, Opole, Olsztyn, Szczecin and in Hungary, in Budapest, Debrecen, Gyor, Kaposvar, Kecskemet, Miskolc, Nyiregyhaza and Pecs in 2019. The investigations were carried out using the volumetric method (Hirst type pollen sampler). Seasonal Pollen Index (SPI) was estimated as the sum of daily average pollen concentrations in the given season. The season ranges from March to May, depending on the geographical latitude. Diagnosis of plane tree pollen allergy is made difficult due to some cross-reactivity with birch, but also alder, hazel, hornbeam, oak, beech, sweet chestnut, and to some extent with grass pollen. In 2019 the pollen season of Platanus started first in Hungary, in Pecs on the April 1st; in Poland the pollen season started in Szczecin and Zielona Gora on the April 4th. At the latest, a pollen season ended in Poland, in Warsaw and Bydgoszcz until May 11th–12th, similarly in Hungary – until May 11th in Budapest and Kaposvar. The differences of pollen seasons duration were very considerable, from 15 to 40 days. Also the differences of the highest airborne concentration especially between both countries were extremely considerable (2105 pollen grains/m3 in Nyíregyháza and 3 pollen grains/m3 in Białystok. The maximum values of seasonal pollen count in Polish cities occurred between April 24th and May 1st, and in Hungarian cities between April 9th and 16th. The highest plane tree pollen allergen hazard occurred in 2019 undoubtedly in Hungary: in Pecs, Kaposvar and Nyiregyhaza, and was ten times higher than in Poland. The highest variability in the analysed seasons was found in the peak value and annual total.

scholarly journals SIDE-EFFECTS AND PATIENTS COMPLIANCE OF SUBCUTANEOUS ALLERGEN-SPECIFIC IMMUNOTHERAPY WITH BIRCHPOLLEN EXTRACT ABSORBED ON CALCIUM PHOSPHAT

2012 ◽  
Vol 9 (6) ◽  
pp. 44-48
Author(s):  
N V Shakhova ◽  
V V Gordeev ◽  
N K Bishevskaya ◽  
T S Ardatova ◽  
V P Tokarev ◽  
...  
Keyword(s):  
Side Effects ◽  
Calcium Phosphate ◽  
Calcium Phosphates ◽  
Allergic Rhinoconjunctivitis ◽  
Pollen Allergen ◽  
Tree Pollen ◽  
Allergen Specific Immunotherapy ◽  
Local Reactions ◽  
High Level ◽  
Local Side

Subcutaneous allergenspecific immunotherapy weakens the symptoms of allergic rhinoconjunctivitis and bronchial asthma. However, there exists the risk of local reactions emergence, as well as the threat of the dangerous anaphylactic reactions. Background. The purpose of this work is to evaluate the frequency and severity of the side-effects and to assess the patients’ compliance with subcutaneous allergenspecific immunotherapy, which uses the tree pollen allergen absorbed onto the calcium phosphate suspension. Methods. The study included 21 children at the age from 5 to 17 with allergic rhinoconjunctivitis with the sensibilization to the allergens of the tree pollen (birch, alder, hazel). The patients had been receiving the treatment with the tree pollen allergen absorbed onto the calcium phosphates suspension for 2 years. All cases of systemic and local side-effects, which appeared during the study, have been analised. Results. In 86% of cases (18 out of 21 patients) local reactions were found. During the study, the total number of injections was 740 with 169 cases of local reactions, which constitutes 22,6% of all injections. In 14,3 percent of cases only slight reactions have appeared. However, 8,3% of injections resulted in pronounced reactions. No systemic reactions were observed; neither of patients has refused to get treatment due to the side-effects. Conclusion. The results of the study have shown the high level of compliance and safety of the subcutaneous allergenspecific immunotherapy, which is based on the use of the tree pollen allergen absorbed onto the calcium phosphate suspension.

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