O2-02-05: Novel candidate genes for late-onset Alzheimer's disease from a large scale association study of 20K functional variants

2006 ◽  
Vol 2 ◽  
pp. S33-S33
Author(s):  
Andrew Grupe ◽  
Yonghong Li ◽  
Charles Rowland ◽  
Richard Abraham ◽  
Paul Hollingworth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Candidate Genes ◽  
Large Scale ◽  
Late Onset ◽  
Functional Variants

An association study of common variation at theMAPTlocus with late-onset Alzheimer's disease

2009 ◽  
Vol 150B (8) ◽  
pp. 1152-1155 ◽  
Author(s):  
Richard Abraham ◽  
Rebecca Sims ◽  
Liam Carroll ◽  
Paul Hollingworth ◽  
Michael C. O'Donovan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Late Onset ◽  
Common Variation

scholarly journals Association Study of the TREM2 Gene and Identification of a Novel Variant in Exon 2 in Iranian Patients with Late-Onset Alzheimer's Disease

2015 ◽  
Vol 24 (4) ◽  
pp. 351-354 ◽  
Author(s):  
Zohreh Mehrjoo ◽  
Amin Najmabadi ◽  
Seyedeh Sedigheh Abedini ◽  
Marzieh Mohseni ◽  
Koorosh Kamali ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Late Onset ◽  
Exon 2 ◽  
Novel Variant ◽  
Iranian Patients

Association study of susceptibility genes for late-onset Alzheimer’s disease in the Japanese population

2012 ◽  
Vol 22 (6) ◽  
pp. 290-293 ◽  
Author(s):  
Tomoyuki Ohara ◽  
Toshiharu Ninomiya ◽  
Yoichiro Hirakawa ◽  
Kyota Ashikawa ◽  
Akira Monji ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Japanese Population ◽  
Late Onset ◽  
Susceptibility Genes

scholarly journals East Asian-specific novel loci associated with late-onset Alzheimer’s disease: the GARD cohort Genome-wide study

2020 ◽  
Author(s):  
Sarang Kang ◽  
Tamil Iniyan Gunasekaran ◽  
Kyu Yeong Choi ◽  
Jang Jae Lee ◽  
Sungho Won ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Large Scale ◽  
Genetic Factors ◽  
Late Onset ◽  
East Asian ◽  
Genetic Heritability ◽  
Genome Wide ◽  
Japanese Sample ◽  
Genomic Studies

ABSTRACTThe high genetic heritability of Alzheimer’s disease has contributed to the multi-directional and large-scale genomic studies to discover genetic factors, and so far many massive studies have been reported. However, the majority of genetic factors have been identified through European races, and relatively few studies using East Asians to discover genetic factors. In this study, East Asian specific loci is first reported through GWAS using GARD cohorts, which have been intensively recruited and managed by a single institution. ApoE-stratified GWAS with the AD cases and matched controls (n=2,291) in the Korean cohort and validation analysis using a Japanese sample (n=1,956) replicated six previously reported loci (genes) including ApoE and suggested two novel susceptible loci in LRIG1 and CACNA1A gene. This study demonstrates that discovery of AD-associated variants can be accomplished in ethnic groups of a more homogeneous genetic background using samples comprising fewer subjects.

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