O4-02-05: Lower microglial Fcγ RI/II and macrophage scavenger receptor a in human Alzheimer's disease after Aβ42 immunisation.

2011 ◽  
Vol 7 ◽  
pp. S684-S685
Author(s):  
Elina Zotova ◽  
Clive Holmes ◽  
James Neal ◽  
Seth Love ◽  
James Nicoll ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Scavenger Receptor ◽  
Macrophage Scavenger Receptor ◽  
Scavenger Receptor A

Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer’s disease pathophysiology

2018 ◽  
Vol 69 ◽  
pp. 336-350 ◽  
Author(s):  
Francisca Cornejo ◽  
Marianne Vruwink ◽  
Claudia Metz ◽  
Paola Muñoz ◽  
Nicole Salgado ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Immune Response ◽  
Scavenger Receptor ◽  
Scavenger Receptor A

scholarly journals Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Kim Wilkinson ◽  
Joseph El Khoury
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Scavenger Receptor ◽  
Scavenger Receptors ◽  
Oxygen Species ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
Ros Scavenger ◽  
Scavenger Receptor A ◽  
The Brain

Alzheimer’s disease (AD) is increasing in prevalence with the aging population. Deposition of amyloid-β(Aβ) in the brain of AD patients is a hallmark of the disease and is associated with increased microglial numbers and activation state. The interaction of microglia with Aβappears to play a dichotomous role in AD pathogenesis. On one hand, microglia can phagocytose and clear Aβ, but binding of microglia to Aβalso increases their ability to produce inflammatory cytokines, chemokines, and neurotoxic reactive oxygen species (ROS). Scavenger receptors, a group of evolutionally conserved proteins expressed on the surface of microglia act as receptors for Aβ. Of particular interest are SCARA-1 (scavenger receptor A-1), CD36, and RAGE (receptor for advanced glycation end products). SCARA-1 appears to be involved in the clearance of Aβ, while CD36 and RAGE are involved in activation of microglia by Aβ. In this review, we discuss the roles of various scavenger receptors in the interaction of microglia with Aβand propose that these receptors play complementary, nonredundant functions in the development of AD pathology. We also discuss potential therapeutic applications for these receptors in AD.

scholarly journals Macrophage Scavenger Receptor A Mediates Adhesion to Apolipoproteins A-I and E

Biochemistry ◽  
2009 ◽  
Vol 48 (50) ◽  
pp. 11858-11871 ◽  
Author(s):  
Claudine Neyen ◽  
Annette Plüddemann ◽  
Pietro Roversi ◽  
Benjamin Thomas ◽  
Lei Cai ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Macrophage Scavenger Receptor ◽  
Scavenger Receptor A

Possible role of scavenger receptor SRCL in the clearance of amyloid-βin Alzheimer's disease

2006 ◽  
Vol 84 (4) ◽  
pp. 874-890 ◽  
Author(s):  
Kenji Nakamura ◽  
Wakana Ohya ◽  
Hiroshi Funakoshi ◽  
Gaku Sakaguchi ◽  
Akira Kato ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Scavenger Receptor

Th-P15:97 Identification of apolipoprotein A-I as A plasma ligand for macrophage scavenger receptor A

2006 ◽  
Vol 7 (3) ◽  
pp. 514
Author(s):  
C. Neyen ◽  
A. Plüddemann ◽  
B. Thomas ◽  
A. Akoulitchev ◽  
L. Cai ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Macrophage Scavenger Receptor ◽  
Apolipoprotein A ◽  
Scavenger Receptor A

Evasion of macrophage scavenger receptor A-mediated recognition by pathogenic streptococci

2008 ◽  
Vol 38 (11) ◽  
pp. 3068-3079 ◽  
Author(s):  
Thomas Areschoug ◽  
Johan Waldemarsson ◽  
Siamon Gordon
Keyword(s):  
Scavenger Receptor ◽  
Macrophage Scavenger Receptor ◽  
Scavenger Receptor A

scholarly journals GPCR19 regulates P2X7R-mediated NLRP3 inflammasomal activation of microglia by Amyloid β in Alzheimer’s diseases

2020 ◽  
Author(s):  
Jahirul Islam ◽  
Jung-Ah Cho ◽  
Ju-yong Kim ◽  
Kyung-Sun Park ◽  
Young-Jae koh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nlrp3 Inflammasome ◽  
Memory Function ◽  
Scavenger Receptor ◽  
Amyloid Β ◽  
Neuronal Loss ◽  
Priming Phase ◽  
5Xfad Mice ◽  
The Brain

Abstract Amyloid β (Aβ) and/or ATP activates NLRP3 inflammasome (N3I) by P2 × 7R ion channel of microglia, which is crucial in neuroinflammation shown in Alzheimer’s disease (AD). Due to polymorphisms, subtypes, and ubiquitous expression of P2 × 7R, inhibition of P2 × 7R has not been effective for AD. We first report that GPCR19 is a prerequisite for P2 × 7R-mediated N3I activation and Taurodeoxycholate (TDCA), a GPCR19 ligand, inhibited the priming phase of N3I activation, suppressed P2 × 7R expression and P2 × 7R-mediated Ca++ mobilization, and N3I oligomerization which is essential for production of IL-1β/IL-18. Further, TDCA increased expression of scavenger receptor (SR) A, enhanced phagocytosis of Aβ, and decreased Aβ plaque numbers in the brain of 5x Familial Alzheimer’s disease (5xFAD) mice. TDCA also reduced microgliosis, prevented neuronal loss, and improved memory function of 5xFAD mice. The pleiotropic roles of GPCR19 in P2 × 7-mediated N3I activation suggest that targeting GPCR19 might resolve neuroinflammation in AD patients.

scholarly journals Macrophage Scavenger Receptor-A–Deficient Mice Are Resistant Against Diabetic Nephropathy Through Amelioration of Microinflammation

Diabetes ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 363-372 ◽  
Author(s):  
Hitomi Kataoka Usui ◽  
Kenichi Shikata ◽  
Motofumi Sasaki ◽  
Shinichi Okada ◽  
Mitsuhiro Matsuda ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Scavenger Receptor ◽  
Macrophage Scavenger Receptor ◽  
Scavenger Receptor A ◽  
Deficient Mice
Sign in / Sign up

Export Citation Format

Share Document