IC-P-196: Decreased resting state functional connectivity at baseline predicts subjective memory complaints after 1 year in cognitively normal individuals and individuals with mild cognitive impairment

2013 ◽  
Vol 9 ◽  
pp. P110-P110 ◽  
Author(s):  
Patrizia Vannini ◽  
Sarah Wigman ◽  
Andrew Ward ◽  
Rebecca Amariglio ◽  
Gad Marshall ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Subjective Memory Complaints ◽  
Resting State Functional Connectivity ◽  
Subjective Memory ◽  
Cognitively Normal ◽  
Memory Complaints ◽  
Normal Individuals

P3-357: HIPPOCAMPAL VOLUME AND FUNCTIONAL CONNECTIVITY DIFFERENTIATE BETWEEN COGNITIVELY NORMAL INDIVIDUALS WITH AND WITHOUT SUBJECTIVE MEMORY COMPLAINTS

2006 ◽  
Vol 14 (7S_Part_23) ◽  
pp. P1223-P1223
Author(s):  
Lauren Zajac ◽  
Bang-Bon Koo ◽  
Yorghos Tripodis ◽  
Asim Mian ◽  
Eric Steinberg ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Hippocampal Volume ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Cognitively Normal ◽  
Memory Complaints ◽  
Normal Individuals

scholarly journals Lower functional hippocampal redundancy in mild cognitive impairment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Stephanie Langella ◽  
◽  
Muhammad Usman Sadiq ◽  
Peter J. Mucha ◽  
Kelly S. Giovanello ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Resting State ◽  
Memory Performance ◽  
Potential Mechanism ◽  
Network Efficiency ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
The Relationship

AbstractWith an increasing prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to an aging population, it is critical to identify and understand neuroprotective mechanisms against cognitive decline. One potential mechanism is redundancy: the existence of duplicate elements within a system that provide alternative functionality in case of failure. As the hippocampus is one of the earliest sites affected by AD pathology, we hypothesized that functional hippocampal redundancy is protective against cognitive decline. We compared hippocampal functional redundancy derived from resting-state functional MRI networks in cognitively normal older adults, with individuals with early and late MCI, as well as the relationship between redundancy and cognition. Posterior hippocampal redundancy was reduced between cognitively normal and MCI groups, plateauing across early and late MCI. Higher hippocampal redundancy was related to better memory performance only for cognitively normal individuals. Critically, functional hippocampal redundancy did not come at the expense of network efficiency. Our results provide support that hippocampal redundancy protects against cognitive decline in aging.

scholarly journals Resting state functional connectivity associated with financial capacity in mild cognitive impairment

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Milap Nowrangi ◽  
Farah Naaz ◽  
Liuyi Chen ◽  
John D. Outen ◽  
Arnold Bakker ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Financial Capacity
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