P4-069: Secreted Amyloid Precursor Protein-Alpha Enhances Long-Term Potentiation Via Protein Synthesis- and Protein Trafficking-Dependent Mechanisms

Protein Trafficking ◽

Long Term Potentiation ◽

Precursor Protein ◽

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

Neurobiology of Disease ◽

10.1016/j.nbd.2008.04.011 ◽

2008 ◽

Vol 31 (2) ◽

pp. 250-260 ◽

Cited By ~ 115

Author(s):

Chanel J. Taylor ◽

David R. Ireland ◽

Irene Ballagh ◽

Katie Bourne ◽

Nicola M. Marechal ◽

...

Keyword(s):

Nmda Receptor ◽

Spatial Memory ◽

Long Term Potentiation ◽

Precursor Protein ◽

Receptor Function ◽

Term Potentiation ◽

Nmda Receptor Function

A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease

Neuropharmacology ◽

10.1016/j.neuropharm.2019.107670 ◽

2019 ◽

Vol 157 ◽

pp. 107670 ◽

Cited By ~ 3

Author(s):

Jodi A. Morrissey ◽

Bruce G. Mockett ◽

Anurag Singh ◽

David Kweon ◽

Shane M. Ohline ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Long Term Potentiation ◽

Transgenic Mouse Model ◽

Precursor Protein ◽

Model Of Alzheimer’S Disease ◽

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats

Neuroscience Letters ◽

10.1016/0304-3940(94)90360-3 ◽

1994 ◽

Vol 169 (1-2) ◽

pp. 77-80 ◽

Cited By ~ 92

Author(s):

M.S. Fazeli ◽

K. Breen ◽

M.L. Errington ◽

T.V.P. Bliss

Keyword(s):

Dentate Gyrus ◽

Long Term Potentiation ◽

Precursor Protein ◽

Term Potentiation ◽

Anaesthetized Rats

Similar levels of long-term potentiation in amyloid precursor protein -null and wild-type mice in the CA1 region of picrotoxin treated slices

Neuroscience Letters ◽

10.1016/s0304-3940(00)01204-0 ◽

2000 ◽

Vol 288 (1) ◽

pp. 9-12 ◽

Cited By ~ 29

Author(s):

Stephen M Fitzjohn ◽

Robin A Morton ◽

Frederick Kuenzi ◽

Ceri H Davies ◽

Guy R Seabrook ◽

...

Keyword(s):

Long Term Potentiation ◽

Precursor Protein ◽

Wild Type ◽

Ca1 Region ◽

P3-309 The contribution of secreted-amyloid precursor protein to the induction of long-term potentiation in anaesthetised rats

Neurobiology of Aging ◽

10.1016/s0197-4580(04)81459-3 ◽

2004 ◽

Vol 25 ◽

pp. S443

Author(s):

Chanel J. Taylor ◽

Paul R. Turner ◽

Warren P. Tate ◽

Wickliffe C. Abraham

Keyword(s):

Long Term Potentiation ◽

Precursor Protein ◽

Term Potentiation ◽

Anaesthetised Rats

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

Neuroscience ◽

10.1016/s0306-4522(98)00410-2 ◽

1999 ◽

Vol 90 (1) ◽

pp. 1-13 ◽

Cited By ~ 204

Author(s):

G.R Dawson ◽

G.R Seabrook ◽

H Zheng ◽

D.W Smith ◽

S Graham ◽

...

Keyword(s):

Cognitive Deficits ◽

Long Term Potentiation ◽

Precursor Protein ◽

Marker Density ◽

Age Related ◽

Term Potentiation ◽

Β Amyloid

Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

Journal of Neuroscience ◽

10.1523/jneurosci.21-13-04691.2001 ◽

2001 ◽

Vol 21 (13) ◽

pp. 4691-4698 ◽

Cited By ~ 131

Author(s):

Stephen M. Fitzjohn ◽

Robin A. Morton ◽

Frederick Kuenzi ◽

Thomas W. Rosahl ◽

Mark Shearman ◽

...

Keyword(s):

Transgenic Mice ◽

Synaptic Transmission ◽

Long Term Potentiation ◽

Precursor Protein ◽

Mutant Form ◽

Age Related ◽

Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice

Journal of Neuroscience ◽

10.1523/jneurosci.22-09-03445.2002 ◽

2002 ◽

Vol 22 (9) ◽

pp. 3445-3453 ◽

Cited By ~ 159

Author(s):

Ilse Dewachter ◽

Delphine Reversé ◽

Nathalie Caluwaerts ◽

Laurence Ris ◽

Cuno Kuipéri ◽

...

Keyword(s):

Transgenic Mice ◽

Amyloid Plaque ◽

Long Term Potentiation ◽

Plaque Formation ◽

Precursor Protein ◽

Presenilin 1 ◽

P3-410: CHF5074, a novel gamma-secretase modulator, completely reverses hippocampal long-term potentiation and nonspatial memory deficits in young, plaque-free, human amyloid precursor protein transgenic mice

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.1953 ◽

2010 ◽

Vol 6 ◽

pp. S573-S573

Author(s):

Bruno P. Imbimbo ◽

Claudia Balducci ◽

Lydia Mare ◽

Gianluigi Forloni ◽

Gino Villetti ◽

...

Keyword(s):

Transgenic Mice ◽

Memory Deficits ◽

Long Term Potentiation ◽

Precursor Protein ◽

Gamma Secretase ◽

Term Potentiation ◽

Nonspatial Memory

A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation

Neurobiology of Disease ◽

10.1016/j.nbd.2016.02.016 ◽

2016 ◽

Vol 91 ◽

pp. 94-104 ◽

Cited By ~ 3

Author(s):

Emilie Trillaud-Doppia ◽

Nicolas Paradis-Isler ◽

Jannic Boehm

Keyword(s):

Amino Acid ◽

Long Term Potentiation ◽

Synaptic Depression ◽

Precursor Protein ◽

Single Amino Acid ◽

Amino Acid Difference ◽

Term Potentiation ◽

Intracellular Domains