O2-10-04: A Regulatory Variant at the TREM Gene Cluster Associates with Decreased Alzheimer’s Disease Risk and Increased TREML1 and TREM2 Brain Gene Expression

2016 ◽  
Vol 12 ◽  
pp. P251-P252 ◽  
Author(s):  
Minerva M. Carrasquillo ◽  
Mariet Allen ◽  
Jeremy D. Burgess ◽  
Samantha L. Strickland ◽  
Shivani Aryal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Cluster ◽  
Disease Risk ◽  
Brain Gene Expression ◽  
Regulatory Variant

scholarly journals A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

2017 ◽  
Vol 13 (6) ◽  
pp. 663-673 ◽  
Author(s):  
Minerva M. Carrasquillo ◽  
Mariet Allen ◽  
Jeremy D. Burgess ◽  
Xue Wang ◽  
Samantha L. Strickland ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Cluster ◽  
Disease Risk ◽  
Brain Gene Expression ◽  
Regulatory Variant

scholarly journals Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

2014 ◽  
Vol 6 (4) ◽  
pp. 39 ◽  
Author(s):  
Mariet Allen ◽  
Michaela Kachadoorian ◽  
Zachary Quicksall ◽  
Fanggeng Zou ◽  
High Chai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk ◽  
Expression Levels ◽  
Brain Gene Expression ◽  
Gene Expression Levels

O3-11-03: Genetic association of variants with late-onset Alzheimer's disease risk and brain gene expression

2012 ◽  
Vol 8 (4S_Part_12) ◽  
pp. P451-P451 ◽  
Author(s):  
Mariet Allen ◽  
Fanggeng Zou ◽  
High Seng Chai ◽  
Curtis Younkin ◽  
Julia Crook ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Disease Risk ◽  
Late Onset ◽  
Brain Gene Expression

scholarly journals Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease

2014 ◽  
Vol 35 (9) ◽  
pp. 1961-1972 ◽  
Author(s):  
Nicole C. Berchtold ◽  
Marwan N. Sabbagh ◽  
Thomas G. Beach ◽  
Ronald C. Kim ◽  
David H. Cribbs ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Brain Gene Expression

Rs4878104 contributes to Alzheimer’s disease risk and regulates DAPK1 gene expression

2017 ◽  
Vol 38 (7) ◽  
pp. 1255-1262 ◽  
Author(s):  
Yang Hu ◽  
Liang Cheng ◽  
Ying Zhang ◽  
Weiyang Bai ◽  
Wenyang Zhou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk

Novel Late-Onset Alzheimer's Disease Loci Variants Associate with Brain Gene Expression (S54.001)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S54.001-S54.001
Author(s):  
M. Allen ◽  
F. Zou ◽  
H. S. Chai ◽  
C. Younkin ◽  
J. Crook ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Brain Gene Expression ◽  
Disease Loci

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

1991 ◽  
Vol 21 (4) ◽  
pp. 855-866 ◽  
Author(s):  
Paul J. Harrison ◽  
Amanda J. L. Barton ◽  
Abdolrahman Najlerahim ◽  
Brendan McDonald ◽  
R. Carl A. Pearson
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Messenger Rna ◽  
Pyramidal Neurons ◽  
Temporal Cortex ◽  
Granule Cell Layer ◽  
Brain Gene Expression ◽  
Mrna Content ◽  
Functionally Impaired

SYNOPSISMessenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly less poly(A) + mRNA than controls in hippocampus (field CA3) and cerebellum (granule cell layer). Analysis of constituent pyramidal neurons showed mean reductions per cell within AD hippocampus (field CA3) and temporal cortex, but not in visual cortex. Similar changes were seen in a small group of non-AD dementias. The finding of reduced poly(A) + mRNA content is another indication of the altered brain gene expression occurring in AD. It is proposed that measurement of poly(A) + mRNA may be valuable in identifying functionally impaired neuronal populations. The methodology also provides a means by which changes in the quantitative distribution of individual mRNAs can be determined relative to that of poly(A) + mRNA as a whole.

scholarly journals O4-10-03: FUNCTIONAL DISSECTION OF ALZHEIMER'S DISEASE BRAIN GENE EXPRESSION SIGNATURES IN HUMANS AND MOUSE MODELS

2019 ◽  
Vol 15 ◽  
pp. P1260-P1260
Author(s):  
Carl Grant Mangleburg ◽  
Ying-Wooi Wan ◽  
Rami Al-Ouran ◽  
Tom V. Lee ◽  
Katherine S. Allison ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Brain Gene Expression ◽  
Gene Expression Signatures

Heterogeneity of Brain Gene Expression in Alzheimer's Disease

1993 ◽  
Vol 679 (1 Markers of Ne) ◽  
pp. 178-187 ◽  
Author(s):  
JOHN R. DUGUID ◽  
CHRISTOPHER TRZEPACZ ◽  
THOMAS KEMPER ◽  
WALLACE W. TOURTELLOTE ◽  
LADISLAV VOLICER
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Gene Expression
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