ESTIMATING YEARS FROM CLINICAL SYMPTOM ONSET FOR SPORADIC ALZHEIMER DISEASE: HOW FAR ARE WE?

2019 ◽  
Vol 15 (7) ◽  
pp. P216-P217
Author(s):  
Guoqiao Wang ◽  
Marco Lorenzi ◽  
Yan Li ◽  
Michael C. Donohue ◽  
Eric Mcdade ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Clinical Symptom ◽  
Symptom Onset ◽  
Sporadic Alzheimer Disease

scholarly journals Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease

2018 ◽  
Vol 75 (5) ◽  
pp. 608 ◽  
Author(s):  
Sylvia Villeneuve ◽  
Jacob W. Vogel ◽  
Julie Gonneaud ◽  
Alexa Pichet Binette ◽  
Pedro Rosa-Neto ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Symptom Onset ◽  
Amyloid Β ◽  
Sporadic Alzheimer Disease

[P4-218]: YEARS TO PARENTAL SYMPTOM ONSET PREDICTS AMYLOID BURDEN IN HEALTHY ELDERLY WITH A PARENTAL HISTORY OF SPORADIC ALZHEIMER DISEASE

2017 ◽  
Vol 13 (7S_Part_28) ◽  
pp. P1352-P1352
Author(s):  
Sylvia Villeneuve ◽  
Jacob W. Vogel ◽  
Julie Gonneaud ◽  
Alexa Pichet Binette ◽  
Pedro Rosa-Neto ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Symptom Onset ◽  
Amyloid Burden ◽  
Parental History ◽  
Healthy Elderly ◽  
History Of ◽  
Sporadic Alzheimer Disease

scholarly journals Depressive symptoms in relation to clinical symptom onset of mild cognitive impairment

2018 ◽  
Vol 31 (04) ◽  
pp. 561-569 ◽  
Author(s):  
Carol K. Chan ◽  
Anja Soldan ◽  
Corinne Pettigrew ◽  
Mei-Cheng Wang ◽  
Jiangxia Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Mild Cognitive Impairment ◽  
Clinical Symptom ◽  
Symptom Onset ◽  
Symptom Severity ◽  
Hamilton Depression Scale ◽  
Cognitively Normal ◽  
Increased Risk ◽  
Time To Onset

ABSTRACTObjective:There is increasing evidence of an association between depressive symptoms and mild cognitive impairment (MCI) in cross-sectional studies, but the longitudinal association between depressive symptoms and risk of MCI onset is less clear. The authors investigated whether baseline symptom severity of depression was predictive of time to onset of symptoms of MCI.Method:These analyses included 300 participants from the BIOCARD study, a cohort of individuals who were cognitively normal at baseline (mean age = 57.4 years) and followed for up to 20 years (mean follow-up = 2.5 years). Depression symptom severity was measured using the Hamilton Depression Scale (HAM-D). The authors assessed the association between dichotomous and continuous HAM-D and time to onset of MCI within 7 years versus after 7 years from baseline (reflecting the mean time from baseline to onset of clinical symptoms in the cohort) using Cox regression models adjusted for gender, age, and education.Results:At baseline, subjects had a mean HAM-D score of 2.2 (SD = 2.8). Higher baseline HAM-D scores were associated with an increased risk of progression from normal cognition to clinical symptom onset ≤ 7 years from baseline (p= 0.043), but not with progression > 7 years from baseline (p= 0.194). These findings remained significant after adjustment for baseline cognition.Conclusions:These results suggest that low levels of depressive symptoms may be predictive of clinical symptom onset within approximately 7 years among cognitively normal individuals and may be useful in identifying persons at risk for MCI due to Alzheimer’s disease.

Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease

2004 ◽  
Vol 369 (3) ◽  
pp. 219-223 ◽  
Author(s):  
Claudia Günther ◽  
Kirsten von Hadeln ◽  
Tomas Müller-Thomsen ◽  
Antonella Alberici ◽  
Giuliano Binetti ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Alzheimer Disease ◽  
Mitochondrial Transcription ◽  
Mitochondrial Transcription Factor ◽  
Mitochondrial Transcription Factor A ◽  
Sporadic Alzheimer Disease

S182 and STM2 gene missense mutations in sporadic Alzheimer disease

1996 ◽  
Vol 67 (4) ◽  
pp. 429-429 ◽  
Author(s):  
Susumu Higuchi ◽  
Sachio Matsushita ◽  
Yoshio Hasegawa ◽  
Taro Muramatsu ◽  
Shigeru Itabashi ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Missense Mutations ◽  
Sporadic Alzheimer Disease

scholarly journals PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

2015 ◽  
Vol 129 (5) ◽  
pp. 757-762 ◽  
Author(s):  
Kurt A. Jellinger ◽  
Irina Alafuzoff ◽  
Johannes Attems ◽  
Thomas G. Beach ◽  
Nigel J. Cairns ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Sporadic Alzheimer Disease

Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models

2015 ◽  
Vol 130 (5) ◽  
pp. 713-729 ◽  
Author(s):  
Yvonne Bouter ◽  
Jose Socrates Lopez Noguerola ◽  
Petra Tucholla ◽  
Gabriela A. N. Crespi ◽  
Michael W. Parker ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Mouse Models ◽  
Sporadic Alzheimer Disease

P4-029: The role of the renin-angiotensin system and apolipoprotein e in a sporadic Alzheimer disease mouse model

2015 ◽  
Vol 11 (7S_Part_17) ◽  
pp. P776-P776
Author(s):  
Christopher John De Vera ◽  
Andrew Ho ◽  
Monica Castro ◽  
Carleton B. Jones ◽  
T. Bucky Jones
Keyword(s):  
Alzheimer Disease ◽  
Mouse Model ◽  
Apolipoprotein E ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Sporadic Alzheimer Disease
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