scholarly journals P1-286: GERIATRIC DEPRESSION SCALE (GDS) ITEM-LEVEL ANALYSIS BY AMYLOID PET AND COGNITION: FINDINGS FROM THE ANTI-AMYLOID TREATMENT IN ASYMPTOMATIC ALZHEIMER'S DISEASE (A4) STUDY SCREENING DATA

2019 ◽  
Vol 15 ◽  
pp. P352-P352
Author(s):  
Jennifer R. Gatchel ◽  
Rebecca Amariglio ◽  
Sietske A.M. Sikkes ◽  
Nancy J. Donovan ◽  
Dorene M. Rentz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Amyloid Pet ◽  
Geriatric Depression ◽  
Item Level ◽  
Level Analysis

scholarly journals Awareness of the COVID-19 Outbreak and Resultant Depressive Tendencies in Patients with Severe Alzheimer’s Disease

2020 ◽  
Vol 77 (2) ◽  
pp. 539-541
Author(s):  
Akito Tsugawa ◽  
Shu Sakurai ◽  
Yuta Inagawa ◽  
Daisuke Hirose ◽  
Yoshitsugu Kaneko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Recognition Rate ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Face Mask ◽  
Geriatric Depression ◽  
Severe Dementia ◽  
Scale Scores ◽  
Current Events

The ongoing coronavirus disease 2019 (COVID-19) pandemic has substantially affected patients with dementia and their caregivers. However, we found not all Alzheimer’s disease (AD) patients were afraid of COVID-19 infection. Therefore, we investigated the association between rate of awareness of COVID-19 and depressive tendency in AD. 126 consecutive outpatients with AD were enrolled in this study from May 25, on the day when the declaration of emergency was lifted in Japan, through June 30, 2020. In addition to routine psychological tests, the participants were asked the following two questions: “Do you know COVID-19?” and “Why are you wearing a face mask?”. Moderate to severe AD patients were found to have a low COVID-19 recognition rate and did not fully understand why they were wearing face masks. In addition, because they did not understand the seriousness of the COVID-19 outbreak, their Geriatric Depression Scale scores were also substantially lower. These results may appear to simply indicate that people with severe dementia are unaware of current events. However, these results provide insights into how to care for patients with dementia and how to allocate the time and support of our limited staff during the COVID-19 outbreak.

scholarly journals Emotional Comparison Between Semantic Dementia and Alzheimer's Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Ping Wang ◽  
Qianhua Zhao ◽  
Yan Zhou ◽  
Zhen Hong ◽  
Qihao Guo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Emotional Processing ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Semantic Dementia ◽  
Depression And Anxiety ◽  
Geriatric Depression ◽  
Emotional Symptoms ◽  
Normal Individuals

Background: Previous studies have suggested that Alzheimer's disease (AD) and semantic dementia (SD) are both associated with emotional processing impairment. However, the degree and type of emotional symptoms between the two types of dementia have not been previously compared.Method: We used the Apathy Evaluation Scale (AES), the Toronto Empathy Questionnaire (TEQ), the Geriatric Depression Scale (GDS) and the Self-rating Anxiety Scale (SAS) to examine apathy, empathy, depression and anxiety, respectively.Results: Between mild AD and mild SD, moderate-to-severe AD and moderate-to-severe SD, the total scores of TEQ are significantly different, but the total scores of GDS, SAS and AES have no significant differences. In addition, normal individuals, AD and SD patients got the similar scores in SAS and GDS.Conclusions: Empathy emotion in SD patients is more severe than that in AD patients. However, apathy, depression and anxiety emotion is similar between the two groups.

scholarly journals Value of Neuropsychological Tests to Identify Patients with Depressive Symptoms on the Alzheimer’s Disease Continuum

2020 ◽  
Vol 78 (2) ◽  
pp. 819-826
Author(s):  
Felix Menne ◽  
Carola Gertrud Schipke ◽  
Arne Klostermann ◽  
Manuel Fuentes-Casañ ◽  
Silka Dawn Freiesleben ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
Neuropsychological Tests ◽  
Neuropsychological Test ◽  
Memory Task ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Area Under The Curve ◽  
Csf Biomarkers

Background: Depressive symptoms often co-occur with Alzheimer’s disease (AD) and can impact neuropsychological test results. In early stages of AD, disentangling cognitive impairments due to depression from those due to neurodegeneration often poses a challenge. Objective: We aimed to identify neuropsychological tests able to detect AD-typical pathology while taking into account varying degrees of depressive symptoms. Methods: A battery of neuropsychological tests (CERAD-NP) and the Geriatric Depression Scale (GDS) were assessed, and cerebrospinal fluid (CSF) biomarkers were obtained. After stratifying patients into CSF positive or negative and into low, moderate, or high GDS score groups, sensitivity and specificity and area under the curve (AUC) were calculated for each subtest. Results: 497 participants were included in the analyses. In patients with low GDS scores (≤10), the highest AUC (0.72) was achieved by Mini-Mental State Examination, followed by Constructional Praxis Recall and Wordlist Total Recall (AUC = 0.714, both). In patients with moderate (11–20) and high (≥21) GDS scores, Trail Making Test-B (TMT-B) revealed the highest AUCs with 0.77 and 0.82, respectively. Conclusion: Neuropsychological tests showing AD-typical pathology in participants with low GDS scores are in-line with previous results. In patients with higher GDS scores, TMT-B showed the best discrimination. This indicates the need to focus on executive function rather than on memory task results in depressed patients to explore a risk for AD.

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