Remote Ischemic Conditioning is Neuroprotective in Necrotizing Enterocolitis-Induced Brain Injury

2019 ◽  
Vol 229 (4) ◽  
pp. e173
Author(s):  
George Biouss ◽  
Niloofar Ganji ◽  
Haitao Zhu ◽  
Bo Li ◽  
Augusto Zani ◽  
...  
Keyword(s):  
Brain Injury ◽  
Necrotizing Enterocolitis ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning

scholarly journals Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuhki Koike ◽  
Bo Li ◽  
Niloofar Ganji ◽  
Haitao Zhu ◽  
Hiromu Miyake ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Mechanism Of Action ◽  
Intestinal Inflammation ◽  
Intestinal Damage ◽  
Invasive Treatment ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Non Invasive ◽  
Intestinal Microcirculation ◽  
Promising Tool

Abstract Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal inflammation and ischemia, as well derangements in intestinal microcirculation. Remote ischemic conditioning (RIC) has emerged as a promising tool in protecting distant organs against ischemia-induced damage. However, the effectiveness of RIC against NEC is unknown. To address this gap, we aimed to determine the efficacy and mechanism of action of RIC in experimental NEC. NEC was induced in mouse pups between postnatal day (P) 5 and 9. RIC was applied through intermittent occlusion of hind limb blood flow. RIC, when administered in the early stages of disease progression, decreases intestinal injury and prolongs survival. The mechanism of action of RIC involves increasing intestinal perfusion through vasodilation mediated by nitric oxide and hydrogen sulfide. RIC is a viable and non-invasive treatment strategy for NEC.

Remote ischemic conditioning preserves cognition and motor coordination in a mouse model of traumatic brain injury

2017 ◽  
Vol 83 (6) ◽  
pp. 1074-1081 ◽  
Author(s):  
Alexander J. Sandweiss ◽  
Asad Azim ◽  
Kareem Ibraheem ◽  
Tally M. Largent-Milnes ◽  
Peter Rhee ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Motor Coordination ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning

Continuous remote ischemic conditioning attenuates cognitive and motor deficits from moderate traumatic brain injury

2018 ◽  
Vol 85 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Viraj Pandit ◽  
Muhammad Khan ◽  
El Rasheid Zakaria ◽  
Tally M. Largent-Milnes ◽  
Mohammad Hamidi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Motor Deficits ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Moderate Traumatic Brain Injury

scholarly journals The Effect of Head Cooling and Remote Ischemic Conditioning on Patients with Traumatic Brain Injury

iScience ◽  
2021 ◽  
pp. 102472
Author(s):  
Fardin Hodoodi ◽  
Dr. Mohammad Allah-Tavakoli ◽  
Dr.Farzad Tajik ◽  
Dr. Iman Fatemi ◽  
Dr. Amir Moghadamahmadi
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Head Cooling

scholarly journals Proteomic analysis identifies plasma correlates of remote ischemic conditioning in the context of experimental traumatic brain injury

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maha Saber ◽  
Khyati V. Pathak ◽  
Marissa McGilvrey ◽  
Krystine Garcia-Mansfield ◽  
Jordan L. Harrison ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Proteomic Analysis ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Experimental Traumatic Brain Injury

scholarly journals Remote ischemic conditioning improves outcome independent of anesthetic effects following shockwave-induced traumatic brain injury

IBRO Reports ◽  
2020 ◽  
Vol 8 ◽  
pp. 18-27
Author(s):  
Eugene Park ◽  
Victoria McCutcheon ◽  
Tamar Telliyan ◽  
Elaine Liu ◽  
Rebecca Eisen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning

scholarly journals Remote Ischemic Conditioning Reduced Acute Lung Injury After Traumatic Brain Injury in The Mouse

Shock ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Maha Saber ◽  
Amanda D. Rice ◽  
Immaculate Christie ◽  
Rebecca G. Roberts ◽  
Kenneth S. Knox ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Acute Lung Injury ◽  
Brain Injury ◽  
Lung Injury ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning
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