scholarly journals Surgical Management of Patients with Complex Perianal Fistula: Results of a US National Case-based Survey to Determine Future Educational Needs

2021 ◽  
Vol 233 (5) ◽  
pp. e27
Author(s):  
Gregory Salinas ◽  
Emily Belcher ◽  
Susan Cazzetta ◽  
Pradeep P. Nazarey ◽  
Sylvie Stacy
2021 ◽  
Vol 116 (1) ◽  
pp. S379-S379
Author(s):  
Gregory D. Salinas ◽  
Emily D. Belcher ◽  
Susan E. Cazzetta ◽  
Pradeep P. Nazarey ◽  
Sylvie Stacy

2018 ◽  
Vol 13 (4) ◽  
pp. 1288
Author(s):  
CarmeloLucio Sturiale ◽  
Antonella Mangraviti ◽  
Edoardo Mazzucchi ◽  
Alessandro Izzo ◽  
Cosimo Sturdà ◽  
...  

2021 ◽  
Vol 37 (1) ◽  
pp. 5-15
Author(s):  
Jong Lyul Lee ◽  
Yong Sik Yoon ◽  
Chang Sik Yu

Perianal fistula is a frequent complication and one of the subclassifications of Crohn disease (CD). It is the most commonly observed symptomatic condition by colorectal surgeons. Accurately classifying a perianal fistula is the initial step in its management in CD patients. Surgical management is selected based on the type of perianal fistula and the presence of rectal inflammation; it includes fistulotomy, fistulectomy, seton procedure, fistula plug insertion, video-assisted ablation of the fistulous tract, stem cell therapy, and proctectomy with stoma creation. Perianal fistulas are also managed medically, such as antibiotics, immunomodulators, and biologics including anti-tumor necrosis factor-alpha agents. The current standard treatment of choice for perianal fistula in CD patients is the multidisciplinary approach combining surgical and medical management; however, the rate of long-term remission is low and is reported to be 50% at most. Therefore, the optimum management strategy for perianal fistulas associated with CD remains controversial. Currently, the goal of management for CD-related perianal fistulas are controlling symptoms and maintaining long-term anal function without proctectomy, while monitoring progression to anorectal carcinoma. This review evaluates perianal fistula in CD patients and determines the optimal surgical management strategy based on recent evidence.


2021 ◽  
pp. 1-16
Author(s):  
Xinyi Cherry Cheung ◽  
Tom Fahey ◽  
Ailin C. Rogers ◽  
John Hogeland Pemberton ◽  
Dara Oliver Kavanagh

<b><i>Background:</i></b> Perianal fistula is a common colorectal condition with an incidence of 9 per 100,000. Many surgical treatments exist, all aiming to eliminate symptoms with minimal risk of recurrence and impact upon continence. Despite extensive evaluation of the therapeutic modalities, no clear consensus exists as to what is the gold standard approach. This systematic review aimed to examine all available evidence pertaining to the surgical management of perianal fistulas. Primary outcomes examined were recurrence and incontinence. <b><i>Summary:</i></b> This study was conducted according to PRISMA guidelines. Primary outcomes were analyzed for each group and expressed as pooled odds ratio with confidence intervals of 95%. 687 studies were identified from which 28 relevant studies were included. There was no significant difference in rates of incontinence identified between various surgical approaches. Glues and plugs show higher recurrence rates. Newer treatments continue to emerge with promise but lack supporting evidence of benefit over conventional therapies. <b><i>Key Messages:</i></b> While we await more robust randomized data, we will continue to proceed cautiously trying to offset the benefits of fistula healing against the inherent risk of altered continence.


Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5872-5872
Author(s):  
Wilson Lam ◽  
Arjun Law ◽  
Umberin Najeeb ◽  
Danny Panisko ◽  
Raymond Jang ◽  
...  

Abstract Background Malignant Hematology is in a new era of exciting novel treatment regimens and modalities, including CAR-T (Chimeric Antigen Receptor T-cells) and BiTE (Bi-specific T-cell Engaging) antibodies. Current trainees require an ever-increasing knowledge and skillset to deliver high quality care to more complex patients. There is limited evidence on the educational needs of hematology residents with these emerging complexities. Moreover, these educational needs themselves are poorly-defined. As a first step, we sought to perform a detailed needs assessment to identify knowledge gaps in our learners. It is our intention to use this information to aid in developing a curriculum incorporating these novel elements. Methods Every year Hematology residents in Canada (Post Graduate Year [PGY] 4 and above) attend the National Hematology Retreat in Toronto, Ontario for a weekend of educational activities, which also serves as preparation for the Royal College of Physicians and Surgeons Hematology certification exam. This past year, residents were invited to participate in a questionnaire to identify perceived and unperceived needs. They were asked to select topics of perceived needs from a pre-selected list. This was followed by a knowledge assessment using case-based questions in leukemia, myeloma, lymphoma, and Blood and Marrow Transplantation [BMT]. The study is approved by the University of Toronto Research Ethics Board. Data were analyzed descriptively as needed. Mean total scores from the case-based questions were compared between post-graduate years using one way ANOVA. All statistical calculations were performed using SPSS version 24. Results 35 of 70 Canadian Hematology residents attending the retreat responded to our survey. Among the respondents, seven were PGY-4, nine were PGY-5, and 19 were PGY-6. Of our pre-selected topics list, residents perceived the most common knowledge gaps existed in management of BMT complications, followed by molecular testing (especially genomics), and novel immune and cellular therapies. The top choices differed in the PGY-4 year (BMT complications, novel immune and cellular therapies and emergency AML complications, Figure 1). Among the respondents answering case-based questions, there was a significant difference in mean scores with increasing length of training (PGY-4: 53%, PGY-5: 70%, PGY-6: 79%, p=0.009). There was a knowledge gap in BMT among all levels of residents, which correlated with their perceived knowledge gaps. However, a majority of them correctly answered the questions on molecular testing and novel immune and cellular therapies. Conclusions Needs assessments are useful in assessing background knowledge and identifying perceived and unperceived needs of trainees. These can be used towards creating a resource that accounts for learning priorities. Our needs assessment of hematology residents across Canada demonstrated that:Knowledge gaps exist among residents at different levels of training, particularly in BMT, compared to other areas of Malignant Hematology. Moreover, this was perceived by residents themselves.Learning priorities of residents may change over the course of their training.Educational curricula should incorporate recent advances in hematology (molecular testing and novel immune and cellular therapies); however more emphasis should also be placed on BMT in general. Disclosures No relevant conflicts of interest to declare.


Author(s):  
Elise Maria Meima - van Praag ◽  
Christianne Johanna Buskens ◽  
Roel Hompes ◽  
Wilhelmus Adrianus Bemelman

Abstract Purpose The aim of this review was to examine current surgical treatments in patients with Crohn’s disease (CD) and to discuss currently popular research questions. Methods A literature search of MEDLINE (PubMed) was conducted using the following search terms: ‘Surgery’ and ‘Crohn’. Different current surgical treatment strategies are discussed based on disease location. Results Several surgical options are possible in medically refractory or complex Crohn’s disease as a last resort therapy. Recent evidence indicated that surgery could also be a good alternative in terms of effectiveness, quality of life and costs as first-line therapy if biologicals are considered, e.g. ileocolic resection for limited disease, or as part of combination therapy with biologicals, e.g. surgery aiming at closure of select perianal fistula in combination with biologicals. The role of the mesentery in ileocolic disease and Crohn’s proctitis is an important surgical dilemma. In proctectomy, evidence is directing at removing the mesentery, and in ileocolic disease, it is still under investigation. Other surgical dilemmas are the role of the Kono-S anastomosis as a preventive measure for recurrent Crohn’s disease and the importance of (non)conventional stricturoplasties. Conclusion Surgical management of Crohn’s disease remains challenging and is dependent on disease location and severity. Indication and timing of surgery should always be discussed in a multidisciplinary team. It seems that early surgery is gradually going to play a more important role in the multidisciplinary management of Crohn’s disease rather than being a last resort therapy.


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