The utility of routine cytology in detecting asymptomatic cervical cancer recurrence

2021 ◽  
Author(s):  
Jamie L. McDowell ◽  
Amanda J. Young ◽  
James A. Daucher ◽  
Scott C. Purinton
Keyword(s):  
Cervical Cancer ◽  
Cancer Recurrence

Surgical resection of locally recurrent cervical cancer: a single institutional 70 patient series

2004 ◽  
Vol 14 (5) ◽  
pp. 846-851 ◽  
Author(s):  
V. Moutardier ◽  
G. Houvenaeghel ◽  
M. Martino ◽  
B. Lelong ◽  
V. J. Bardou ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Local Control ◽  
Cancer Recurrence ◽  
Palliative Surgery ◽  
Morbidity Rate ◽  
Actuarial Survival ◽  
Recurrent Cervical Cancer ◽  
Actuarial Survival Rate ◽  
Life Threatening ◽  
Threatening Situation

Pelvic recurrence of cervical cancer is a life-threatening situation and only local control can provide hope for remission. The aim of this study was to evaluate the role of surgery in the treatment of cervical cancer recurrence. This retrospective study analyzed a series of 70 patients who underwent resection of cervix locoregional recurrence. Thirteen patients had palliative salvage surgery for pelvic complications. Twenty-nine resections were considered as curative. Fifty recurrences required pelvic exenterations. The hospital mortality rate was 9% and the morbidity rate was 44%. Overall 5-year actuarial survival rate was 23%. Survival was significantly higher: (a) after curative resection and (b) after centropelvic recurrence resection. Local control was obtained in 48% of the cases and 13 patients are alive with a median follow-up of 75 months. In conclusion, the results of this small and heterogen series seem to justify an attempt to resection for centropelvic recurrences whenever possible. Palliative surgery should be reserved to salvage therapy and highly selected patients.

Significance of microvascular density (MVD) in cervical cancer recurrence

2003 ◽  
Vol 13 (6) ◽  
pp. 856-862 ◽  
Author(s):  
D. Cantu De León ◽  
C. Lopez-Graniel ◽  
M. Frias Mendivil ◽  
G. Chanona Vilchis ◽  
C. Gomez ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell ◽  
Cancer Recurrence ◽  
Disease Free Survival ◽  
Cancer Stage ◽  
Disease Free Interval ◽  
Free Survival ◽  
Free Interval ◽  
Global Survival ◽  
Disease Free

The purpose of this retrospective study of 118 patients with squamous cell cervical cancer from January 1990 to December 1993 was to evaluate angiogenesis as predictive factor of recurrence in cervical cancer stages II–III treated with standard radiotherapy. Microvessel density (MVD) was evaluated and correlated with other prognostic factors. MVD was greater than 20 in 67.8% of patients with recurrence (P = 0.002) in comparison to 39% of patients without. Disease-free survival was shorter in stage IIA and MVD >20 (P = 0.0193) as well as for stage IIB (P < 0.05), but not for IIIB (P = 0.1613). Global survival was significantly shorter when MVD was >20 (P = 0.0316). For stage IIA and MVD >20 survival was shorter (P = 0.0008) for stage IIB (P < 0.05) but not for IIIB (P = 0.14). Patients younger than 40 years and MVD >20 had poorer disease-free interval and survival (P = 0.0029). MVD in patients with squamous cell cervical cancer stage II and age younger than 40 may play a role in predicting recurrence and survival.

Local, combination chemotherapy in prevention of cervical cancer recurrence after surgery by using nanofibers co-loaded with cisplatin and curcumin

RSC Advances ◽  
2015 ◽  
Vol 5 (129) ◽  
pp. 106325-106332 ◽  
Author(s):  
Yue Ma ◽  
Xue Wang ◽  
Shan Zong ◽  
Zhiyun Zhang ◽  
Zhigang Xie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Combination Chemotherapy ◽  
Cancer Recurrence ◽  
Electrospun Nanofibers

Electrospun nanofibers co-loaded with cisplatin and curcumin effectively reduce the risk of local cervical cancer recurrence after surgery.

Time to cervical cancer recurrence on maintenance bevacizumab

2020 ◽  
Vol 159 ◽  
pp. 173
Author(s):  
A.D. Borgstadt ◽  
C.A. Mathews
Keyword(s):  
Cervical Cancer ◽  
Cancer Recurrence

scholarly journals α-Actinin-4 regulates cancer stem cell properties and chemoresistance in cervical cancer

2019 ◽  
Vol 41 (7) ◽  
pp. 940-949 ◽  
Author(s):  
Jaeyeon Jung ◽  
Suhyun Kim ◽  
Hyoung-Tae An ◽  
Jesang Ko
Keyword(s):  
Cervical Cancer ◽  
Cell Cycle Progression ◽  
Cancer Metastasis ◽  
Epithelial To Mesenchymal Transition ◽  
Cancer Recurrence ◽  
Actin Binding ◽  
Mesenchymal Transition ◽  
Key Factor ◽  
Sphere Formation

Abstract Cancer stem cells (CSCs) initiate tumors and possess the properties of self-renewal and differentiation. Since they are responsible for chemoresistance, CSCs are known to be a key factor in cancer recurrence. α-Actinin-4 (ACTN4) is an actin-binding protein that is involved in muscle differentiation and cancer metastasis. It promotes epithelial to mesenchymal transition and cell cycle progression via β-catenin stabilization in cervical cancer. In the present study, we investigated the role of ACTN4 in regulating cancer cell stemness and chemoresistance in cervical cancer. Results from the gene expression database analysis showed that ACTN4 mRNA expression was elevated in cancerous cervices when compared with normal cervices. Furthermore, ACTN4 knockdown suppressed sphere formation and CSC proliferation. It also decreased CSC size and CD44high/CD24low cell population. ACTN4-knockdown CSCs were sensitive to anticancer drugs, which was observed by down-regulation of the ATP-binding cassette family G2 involved in drug resistance. Finally, ACTN4-knockdown CSCs formed reduced tumors in vivo when compared with control CSCs. Overall, these findings suggest that ACTN4 regulates CSC properties and contributes to chemoresistance in cervical cancer.

Photodynamic therapy in the prevention of HPV-associated cervical cancer recurrence

GYNECOLOGY ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. 46-48 ◽  
Author(s):  
O.I. Trushina ◽  
◽  
E.G. Novikova ◽  
A.A. Kostin ◽  
A.T. Asratov ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Photodynamic Therapy ◽  
Cancer Recurrence
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