Simultaneous determination of nintedanib and its metabolite BIBF 1202 in different tissues of mice by UPLC–MS/MS and its application in drug tissue distribution study

2015 ◽  
Vol 1002 ◽  
pp. 239-244 ◽  
Author(s):  
Xiao-wei Xu ◽  
Xin-juan Su ◽  
Yu-niao Zhang ◽  
Xiao-kang Zheng ◽  
Peng-fei Lv ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Simultaneous Determination ◽  
Distribution Study ◽  
Tissue Distribution Study ◽  
Different Tissues

Quantitative determination of periplocymarin in rat plasma and tissue by LC-MS/MS: application to pharmacokinetic and tissue distribution study

2016 ◽  
Vol 30 (8) ◽  
pp. 1195-1201 ◽  
Author(s):  
Kaijing Yan ◽  
Xiangyang Wang ◽  
Yumeng Jia ◽  
Yang Chu ◽  
Xiufeng Guan ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Tissue Distribution ◽  
Rat Plasma ◽  
Distribution Study ◽  
Tissue Distribution Study

scholarly journals Simultaneous Measurement of Tadehaginoside and its Principal Metabolite in Rats by HPLC–MS/MS and its Application in Pharmacokinetics and Tissue Distribution Study

2021 ◽  
Author(s):  
Cai-Yun Zhang ◽  
Ya-Ting Lu ◽  
Yin-Feng Tan ◽  
Lin Dong ◽  
Zhi-Heng Su ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
High Performance ◽  
Biological Activities ◽  
Intragastric Administration ◽  
Distribution Study ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Tissue Distribution Study

Abstract Background Tadehaginoside, an active ingredient isolated from Tadehagi triquetrum L., exhibited various biological activities. However, the pharmacokinetics and tissue-distribution which affects tadehaginoside’s therapeutic actions and application remain elusive.MethodsTo clarify the metabolism of tadehaginoside in vivo, a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established to detect the level of tadehaginoside in plasma and eleven tat tissues (brain, heart, liver, spleen, lungs, kidneys, stomach, small intestine, skeletal muscle, body fat, and testes). Besides, this validated method was also successfully applied to the quantitative determination of its metabolite, p-hydroxycinnamic acid (HYD) in plasma. The pharmacokinetic and tissue-distribution of tadehaginoside were investigated by this developed method. ResultsThe pharmacokinetic study indicated that tadehaginoside in plasma of rats with intragastric administration showed relatively low concentration may be due to the formation of its metabolite, and the quick absorption of tadehaginoside was detected following intravenous administration. Tissue-distribution study indicated that kidney and spleen were the major distribution organs for tadehaginoside in rats. ConclusionsThese results could provide clues for exploring the bioactivity of tadehaginoside based on its pharmacokinetic characteristics.

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