scholarly journals Chiral analysis of selected enantiomeric drugs relevant in doping controls

2021 ◽  
pp. 100017
Author(s):  
Ana Rubio ◽  
Christian Görgens ◽  
Sven Guddat ◽  
Thomas Piper ◽  
Ann-Marie Garzinsky ◽  
...  
Keyword(s):  
Chiral Analysis ◽  
In Doping

CHIRAL ANALYSIS OF ISOPULEGOL BY FOURIER TRANSFORM MOLECULAR ROTATIONAL SPECTROSCOPY

2016 ◽  
Author(s):  
Luca Evangelisti ◽  
Brooks Pate ◽  
Lorenzo Spada ◽  
Nathan Seifert
Keyword(s):  
Fourier Transform ◽  
Chiral Analysis ◽  
Rotational Spectroscopy

INTERNAL DYNAMICS AND CHIRAL ANALYSIS OF PULEGONE, USING MICROWAVE BROADBAND SPECTROSCOPY

2017 ◽  
Author(s):  
Anna Krin ◽  
Juan Lopez ◽  
Susana Blanco ◽  
Pablo Pinacho ◽  
Juan Avilés-Moreno ◽  
...  
Keyword(s):  
Chiral Analysis ◽  
Internal Dynamics ◽  
Broadband Spectroscopy

Preparation and Thermoelectric Transport Properties of In-doping b-Zn4Sb3 Bulk Thermoelectric Materials

2010 ◽  
Vol 25 (6) ◽  
pp. 598-602 ◽  
Author(s):  
Bing MA ◽  
Su-Dan CHENG ◽  
Wen-Yu ZHAO ◽  
Qing-Jie ZHANG
Keyword(s):  
Transport Properties ◽  
Thermoelectric Materials ◽  
Thermoelectric Transport ◽  
In Doping ◽  
Thermoelectric Transport Properties

Confirmation of Long Term Excreted Metabolites of Stanozolol by Gas Chromatography Coupled with High Resolution Mass Spectrometry (GC/HRMS)

2008 ◽  
Vol 59 (7) ◽  
Author(s):  
Ileana Vajiala ◽  
Ruxandra Subasu ◽  
Mirela Zorio ◽  
Rodica Picu
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Parent Compound ◽  
Urine Specimen ◽  
Decision Making Process ◽  
Purification Procedure ◽  
Specific Identification ◽  
Immunoaffinity Purification ◽  
In Doping ◽  
Resolution Mass

Upon screening identification of Stanozolol, GC/HRMS confirmation of the suspicious sample is done by reanalysis of the urine specimen, where a specific immunoaffinity purification procedure is used to selectively isolate the long term excreted metabolites of Stanozolol. By meeting the specific identification criteria for more than one metabolite of the same parent compound, additional evidence could be obtained in the decision making process in doping control.

A Review of Analytical Methods for the Determination of Tibolone: Pharmacokinetics and Pharmaceutical Formulations Analysis and Application in Doping Control

2020 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Marilene Lopes Ângelo ◽  
Fernanda de Lima Moreira ◽  
Ana Laura Araújo Santos ◽  
Hérida Regina Nunes Salgado ◽  
Magali Benjamim de Araújo
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
Estrogenic Activity ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Doping Control ◽  
Specific Effects ◽  
In Doping

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.

scholarly journals A New Approach for Approximate Solution of ADE: Physical-Based Modeling of Carriers in Doping Region

Mathematics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 458
Author(s):  
Leobardo Hernandez-Gonzalez ◽  
Jazmin Ramirez-Hernandez ◽  
Oswaldo Ulises Juarez-Sandoval ◽  
Miguel Angel Olivares-Robles ◽  
Ramon Blanco Sanchez ◽  
...  
Keyword(s):  
Differential Equation ◽  
Approximate Solution ◽  
Analytic Solution ◽  
Order Differential Equation ◽  
Electric Circuit ◽  
New Approach ◽  
In Doping ◽  
Electric Behavior ◽  
Spatio Temporal ◽  
Physical Phenomena

The electric behavior in semiconductor devices is the result of the electric carriers’ injection and evacuation in the low doping region, N-. The carrier’s dynamic is determined by the ambipolar diffusion equation (ADE), which involves the main physical phenomena in the low doping region. The ADE does not have a direct analytic solution since it is a spatio-temporal second-order differential equation. The numerical solution is the most used, but is inadequate to be integrated into commercial electric circuit simulators. In this paper, an empiric approximation is proposed as the solution of the ADE. The proposed solution was validated using the final equations that were implemented in a simulator; the results were compared with the experimental results in each phase, obtaining a similarity in the current waveforms. Finally, an advantage of the proposed methodology is that the final expressions obtained can be easily implemented in commercial simulators.

Simultaneous determination of the concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe

2021 ◽  
Vol 13 (16) ◽  
pp. 1905-1910
Author(s):  
Lamei Yang ◽  
Feng Luo ◽  
Weili Wei
Keyword(s):  
Amino Acids ◽  
Simultaneous Determination ◽  
Enantiomeric Excess ◽  
Chiral Analysis

An achiral easy-to-synthesize coumarin aldehyde probe was designed and synthesized for chiral analysis of amino acids.

A micellar electrokinetic chromatography–mass spectrometry approach using in-capillary diastereomeric derivatization for fully automatized chiral analysis of amino acids

2016 ◽  
Vol 1467 ◽  
pp. 400-408 ◽  
Author(s):  
Radu-Cristian Moldovan ◽  
Ede Bodoki ◽  
Timea Kacsó ◽  
Anne-Catherine Servais ◽  
Jacques Crommen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
Micellar Electrokinetic Chromatography ◽  
Chiral Analysis ◽  
Electrokinetic Chromatography ◽  
Chromatography Mass Spectrometry

scholarly journals Structure Determination, Conformational Flexibility, Internal Dynamics, and Chiral Analysis of Pulegone and Its Complex with Water

2017 ◽  
Vol 24 (3) ◽  
pp. 721-729 ◽  
Author(s):  
Anna Krin ◽  
Cristóbal Pérez ◽  
Pablo Pinacho ◽  
María Mar Quesada-Moreno ◽  
Juan Jesús López-González ◽  
...  
Keyword(s):  
Structure Determination ◽  
Conformational Flexibility ◽  
Chiral Analysis ◽  
Internal Dynamics
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