Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs

2009 ◽  
Vol 134 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Angel Tan ◽  
Spomenka Simovic ◽  
Andrew K. Davey ◽  
Thomas Rades ◽  
Clive A. Prestidge
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Poorly Soluble Drugs ◽  
Oral Delivery System ◽  
Poorly Soluble

scholarly journals Relative Contributions of Solubility and Mobility to the Stability of Amorphous Solid Dispersions of Poorly Soluble Drugs: A Molecular Dynamics Simulation Study

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 101 ◽  
Author(s):  
Michael Brunsteiner ◽  
Johannes Khinast ◽  
Amrit Paudel
Keyword(s):  
Molecular Dynamics ◽  
Oral Delivery ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Dynamics Simulation ◽  
Limiting Factor ◽  
Poorly Soluble Drugs ◽  
Formulation Development ◽  
Amorphous Solid Dispersions ◽  
Poorly Soluble

Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of poorly soluble drugs. The limiting factor for the applicability of this approach is the physical (in)stability of the amorphous phase in solid samples. Minimizing the risk of reduced shelf life for a new drug by establishing a suitable excipient/polymer-type from first principles would be desirable to accelerate formulation development. Here, we perform Molecular Dynamics simulations to determine properties of blends of eight different polymer–small molecule drug combinations for which stability data are available from a consistent set of literature data. We calculate thermodynamic factors (mixing energies) as well as mobilities (diffusion rates and roto-vibrational fluctuations). We find that either of the two factors, mobility and energetics, can determine the relative stability of the amorphous form for a given drug. Which factor is rate limiting depends on physico-chemical properties of the drug and the excipients/polymers. The methods outlined here can be readily employed for an in silico pre-screening of different excipients for a given drug to establish a qualitative ranking of the expected relative stabilities, thereby accelerating and streamlining formulation development.

Indomethacin-5-fluorouracil-methyl ester dry emulsion: a potential oral delivery system for 5-fluorouracil

2010 ◽  
Vol 36 (6) ◽  
pp. 647-656 ◽  
Author(s):  
Jing Wang ◽  
Yanchen Hu ◽  
Ling Li ◽  
Tongying Jiang ◽  
Siling Wang ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Delivery System ◽  
Oral Delivery ◽  
Oral Delivery System ◽  
Dry Emulsion

Solvent-free synthesis of acetylated cashew gum for oral delivery system of insulin

2019 ◽  
Vol 207 ◽  
pp. 601-608 ◽  
Author(s):  
Eliadna de Lemos Vasconcelos Silva ◽  
Antônia Carla de Jesus Oliveira ◽  
Yuri Basílio Gomes Patriota ◽  
António José Ribeiro ◽  
Francisco Veiga ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Solvent Free ◽  
Cashew Gum ◽  
Oral Delivery System ◽  
Solvent Free Synthesis

Formulation of lipid bearing pellets as a delivery system for poorly soluble drugs

2013 ◽  
Vol 446 (1-2) ◽  
pp. 136-144 ◽  
Author(s):  
Shruti Chopra ◽  
Natarajan Venkatesan ◽  
Guru V. Betageri
Keyword(s):  
Delivery System ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Oral Delivery System for Two-pulse Colonic Release of Protein Drugs and Protease Inhibitor/Absorption Enhancer Compounds

2011 ◽  
Vol 100 (8) ◽  
pp. 3251-3259 ◽  
Author(s):  
Maria Dorly Del Curto ◽  
Alessandra Maroni ◽  
Luca Palugan ◽  
Lucia Zema ◽  
Andrea Gazzaniga ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Delivery System ◽  
Oral Delivery ◽  
Absorption Enhancer ◽  
Protein Drugs ◽  
Oral Delivery System ◽  
Colonic Release
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