Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen–cimetidine mixtures prepared by mechanical activation

2009 ◽  
Vol 136 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Morten Allesø ◽  
Norman Chieng ◽  
Sönke Rehder ◽  
Jukka Rantanen ◽  
Thomas Rades ◽  
...  
Keyword(s):  
Mechanical Activation ◽  
Dissolution Rate ◽  
Binary Systems ◽  
Enhanced Dissolution ◽  
Synchronized Release

The Effect of Superdisintegrants on the Dissolution of Promethazine. HCl Fast Dissolving Tablets

2010 ◽  
Vol 3 (1) ◽  
pp. 867-871
Author(s):  
Ganesh kumar Gudas ◽  
Manasa B ◽  
Senthil Kumaran K ◽  
Rajesham V V ◽  
Kiran Kumar S ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Angle Of Repose ◽  
Content Uniformity ◽  
Disintegration Time ◽  
Enhanced Dissolution ◽  
Weight Variation ◽  
Compressibility Index ◽  
Chemoreceptor Trigger Zone ◽  
Trigger Zone ◽  
Standard Limit

Promethazine.HCl is a potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Promethazine is also believed to inhibit the medullary chemoreceptor trigger zone, and antagonize apomorphine -induced vomiting. Fast dissolving tablets of Promethazine.HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The precompression blend was tested for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Promethazine.HCl was prepared and studied and the formulation S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present study an attempt has been made to prepare fast dissolving tablets of Promethazine.HCl, by using different superdisintegrants with enhanced disintegration and dissolution rate. 

Controlled precipitation for enhanced dissolution rate of flurbiprofen: development of rapidly disintegrating tablets

2017 ◽  
Vol 43 (9) ◽  
pp. 1430-1439 ◽  
Author(s):  
Ebtessam A. Essa ◽  
Amira O. Elmarakby ◽  
Ahmed M. A. Donia ◽  
Gamal M. El Maghraby
Keyword(s):  
Dissolution Rate ◽  
Enhanced Dissolution ◽  
Controlled Precipitation

Acetone-assisted co-processing of meloxicam with amino acids for enhanced dissolution rate

2020 ◽  
Vol 25 (7) ◽  
pp. 882-891
Author(s):  
Nancy E. Elkholy ◽  
Amal A. Sultan ◽  
Ghada H. Elosaily ◽  
Gamal M. El Maghraby
Keyword(s):  
Amino Acids ◽  
Dissolution Rate ◽  
Enhanced Dissolution

Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants

2009 ◽  
Vol 73 (1) ◽  
pp. 154-161 ◽  
Author(s):  
P. Srinarong ◽  
J.H. Faber ◽  
M.R. Visser ◽  
W.L.J. Hinrichs ◽  
H.W. Frijlink
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Enhanced Dissolution

Enhanced dissolution rate of simvastatin using spherical crystallization technique

2010 ◽  
Vol 16 (5) ◽  
pp. 529-535 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Naser Tavakoli ◽  
Fatemeh Akhavan Salamat
Keyword(s):  
Dissolution Rate ◽  
Enhanced Dissolution ◽  
Spherical Crystallization

scholarly journals FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALDECOXIB

2018 ◽  
Vol 7 (6) ◽  
Author(s):  
K Kareemuddin Ansari ◽  
Neeraj Sharma
Keyword(s):  
Dissolution Rate ◽  
Methyl Cellulose ◽  
Aqueous Solubility ◽  
Angle Of Repose ◽  
Content Uniformity ◽  
Carboxy Methyl Cellulose ◽  
Compression Technique ◽  
Disintegration Time ◽  
Enhanced Dissolution ◽  
Carboxy Methyl

Valdecoxib is a selective COX- II inhibitor with anti – inflammatory, analgesic and antipyretic properties. The poor aqueous solubility of the drug leads to variable dissolution rates. In the present study an attempt has been made to prepare fast dissolving tablets of Valdecoxib in the oral cavity with enhanced dissolution rate. The fast dissolving tablets of Valdecoxib was prepared with some carriers (polymers) and super disintegrants such as Polyvinyl Pyrrolidone (PVP), Sodium Carboxy Methyl Cellulose (SCMC), Crospovidone NF and β – Cyclodextrin. The above mentioned all carriers and superdisintegrants were taken in different proportions of 5, 10, and 15%. All the formulations of the fast dissolving tablets of Valdecoxib were prepared by direct compression technique. The blend was examined for Angle of repose, Bulk density, Compressibility index and Hausner’s ratio. The prepared tablets were evaluated for hardness, drug content uniformity, friability, disintegration time and dissolution rate. An effective pleasant testing formulation released 99.88% drug within 10 minutes. The prepared formulations drug release was found to be comparable with the marketed dispersible tablets. Keywords: Fast dissolving tablets, Super-disintegrants, Valdecoxib, Crosspovidone, Sodium Carboxy Methyl Cellulose.

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