Layered double hydroxides as effective carrier for anticancer drugs and tailoring of release rate through interlayer anions

AbstractThe effect of a Mg- and Al-containing layered double hydroxide (LDH), used as an additive or as a matrix, on the dissolution and solubility of two non-steroidal anti-inflammatory drugs (NSAIDs), namely, mefenamic and meclofenamic acids, is reported. The use of MgAl-LDH enhances the solubility of mefenamic acid at the three pH values tested, and the value is larger when the acid is intercalated as opposed to simply being mixed with the layered material. For pure mefenamic acid, the most unfavourable pH is 1.2, while for the physical mixture and the sample with the intercalated drug, the most unfavourable pH is 4.5, for which the minimum increase in the amount of dissolved acid is recorded. The (dissolution) release-rate for both drugs when they are intercalated between the layers is much slower than for the physical mixture or for the dissolution of the pure drug.

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EFFICIENT REMOVAL OF ANIONIC DYE POLLUTANT BY NIMGAL LAYERED DOUBLE HYDROXIDES OF VARIABLE COMPOSITION

Catalysis in Green Chemistry and Engineering ◽

10.1615/catalgreenchemeng.2018028634 ◽

2018 ◽

Vol 1 (4) ◽

pp. 307-323

Author(s):

Dipshikha Bharali ◽

Pankaj Bharali ◽

Ramesh Ch. Deka

Keyword(s):

Layered Double Hydroxides ◽

Variable Composition ◽

Efficient Removal ◽

Anionic Dye ◽

Double Hydroxides

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Acceptorless amine dehydrogenation and transamination using Pd-doped layered double hydroxides

10.26434/chemrxiv.6998204.v2 ◽

2018 ◽

Author(s):

Diana Ainembabazi ◽

Nan An ◽

Jinesh Manayil ◽

Kare Wilson ◽

Adam Lee ◽

...

Keyword(s):

Layered Double Hydroxides ◽

Oxidation States ◽

Secondary Amines ◽

Primary Amines ◽

Acid Dissolution ◽

Oxidative Amination ◽

Strong Function ◽

Excellent Activity ◽

High Yields ◽

Double Hydroxides

<div> <p>The synthesis, characterization, and activity of Pd-doped layered double hydroxides (Pd-LDHs) for for acceptorless amine dehydrogenation is reported. These multifunctional catalysts comprise Brønsted basic and Lewis acidic surface sites that stabilize Pd species in 0, 2+, and 4+ oxidation states. Pd speciation and corresponding cataytic performance is a strong function of metal loading. Excellent activity is observed for the oxidative transamination of primary amines and acceptorless dehydrogenation of secondary amines to secondary imines using a low Pd loading (0.5 mol%), without the need for oxidants. N-heterocycles, such as indoline, 1,2,3,4-tetrahydroquinoline, and piperidine, are dehydrogenated to the corresponding aromatics with high yields. The relative yields of secondary imines are proportional to the calculated free energy of reaction, while yields for oxidative amination correlate with the electrophilicity of primary imine intermediates. Reversible amine dehydrogenation and imine hydrogenation determine the relative imine:amine selectivity. Poisoning tests evidence that Pd-LDHs operate heterogeneously, with negligible metal leaching; catalysts can be regenerated by acid dissolution and re-precipitation.</p> </div> <br>

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Carbonate Form of Mg,Al-Layered Double Hydroxides for Concentrating Eu(III) and Its Subsequent Analytical Determination in Natural Aqueous Media

Journal of Water Chemistry and Technology ◽

10.3103/s1063455x20050094 ◽

2020 ◽

Vol 42 (5) ◽

pp. 365-372

Author(s):

G. N. Pshinko ◽

L. N. Puzyrnaya ◽

V. S. Shunkov ◽

B. P. Yatsik

Keyword(s):

Layered Double Hydroxides ◽

Aqueous Media ◽

Analytical Determination ◽

Double Hydroxides

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Antibiotic-anionic Clay Matrix Used for Drug Controlled Release

Revista de Chimie ◽

10.37358/rc.18.2.6098 ◽

2018 ◽

Vol 69 (2) ◽

pp. 321-323

Author(s):

Georgeta Zegan ◽

Elena Mihaela Carausu ◽

Loredana Golovcencu ◽

Alina Sodor Botezatu ◽

Eduard Radu Cernei ◽

...

Keyword(s):

Controlled Release ◽

Layered Double Hydroxides ◽

Bioactive Molecules ◽

Drug Controlled Release ◽

Anionic Clays ◽

Anionic Clay ◽

Toxicological Studies ◽

High Efficient ◽

Clay Matrix ◽

Double Hydroxides

Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.

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