Drug depot-anchoring hydrogel: A self-assembling scaffold for localized drug release and enhanced stem cell differentiation

2017 ◽  
Vol 261 ◽  
pp. 234-245 ◽  
Author(s):  
Ruixiang Li ◽  
Zhiqing Pang ◽  
Huining He ◽  
Seungjin Lee ◽  
Jing Qin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Drug Release ◽  
Stem Cell Differentiation ◽  
Self Assembling

scholarly journals Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 840 ◽  
Author(s):  
Markus Witzler ◽  
Dominik Büchner ◽  
Sarah Shoushrah ◽  
Patrick Babczyk ◽  
Juliana Baranova ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Drug Release ◽  
Bone Regeneration ◽  
Cell Biology ◽  
Bone Structure ◽  
Stem Cell Differentiation ◽  
Interdisciplinary Field ◽  
Novel Scaffold

Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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