Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

Current Pharmaceutical Design ◽

10.2174/1381612823666170526111029 ◽

2018 ◽

Vol 23 (35) ◽

Cited By ~ 8

Author(s):

Sally Sabra ◽

Mona Abdelmoneem ◽

Mahmoud Abdelwakil ◽

Moustafa Taha Mabrouk ◽

Doaa Anwar ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Drug ◽

Natural Polymers ◽

Anti Cancer ◽

Drug Delivery Applications ◽

Self Assembled ◽

Cancer Drug Delivery

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Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

Current Pharmaceutical Design ◽

10.2174/1381612826666200612164511 ◽

2020 ◽

Vol 26 (36) ◽

pp. 4551-4568

Author(s):

Mohammad Kashif Iqubal ◽

Sadaf Saleem ◽

Ashif Iqubal ◽

Aiswarya Chaudhuri ◽

Faheem Hyder Pottoo ◽

...

Keyword(s):

Drug Delivery ◽

Wound Healing ◽

Photodynamic Therapy ◽

Growth Factors ◽

Combination Therapy ◽

Healing Process ◽

Wound Healing Process ◽

Wound Site ◽

Synthetic Drugs ◽

Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

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Self-assembled Camptothecin derivatives – Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy

Journal of Photochemistry and Photobiology B Biology ◽

10.1016/j.jphotobiol.2021.112124 ◽

2021 ◽

Vol 215 ◽

pp. 112124

Author(s):

Yiping Guo ◽

Hongmei Liu ◽

Haijun Xiao ◽

Minghao Yuan ◽

Yushi Liu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Self Assembled

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Cytokine induced killer cells-assisted delivery of chlorin e6 mediated self-assembled gold nanoclusters to tumors for imaging and immuno-photodynamic therapy

Biomaterials ◽

10.1016/j.biomaterials.2018.03.048 ◽

2018 ◽

Vol 170 ◽

pp. 1-11 ◽

Cited By ~ 40

Author(s):

Fangfang Xia ◽

Wenxiu Hou ◽

Yanlei Liu ◽

Wentao Wang ◽

Yu Han ◽

...

Keyword(s):

Photodynamic Therapy ◽

Gold Nanoclusters ◽

Chlorin E6 ◽

Killer Cells ◽

Assisted Delivery ◽

Self Assembled

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Researches on Preparation of Photosan Loaded Magnetic Silica Anoparticles and their Anti-Tumor Effects in Photodynamic Therapy

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.622-623.821 ◽

2012 ◽

Vol 622-623 ◽

pp. 821-826

Author(s):

Yu Wen ◽

Xiao Feng Deng ◽

Liang Liang Liu ◽

Shu Yun Shi ◽

Li Xiong

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Sol Gel ◽

Haematoporphyrin Derivative ◽

X Ray Diffraction ◽

Transmission Electron ◽

Good Biocompatibility ◽

Low Solubility

Photodynamic therapy (PDT) is an effective, noninvasive and nontoxic therapeutics for cancer and some other diseases. It is becoming a alternative of traditional therapeutics for cancers. But the efficacy of PDT was restricted by insufficient selectivity and low solubility. In this study, novel multifunctional silica-based magnetic nanoparticles were prepared as targeting drug delivery system to achieve higher specificity and better solubility. Haematoporphyrin derivative (photosan) was used as photosensitizer. Magnetite nanoparticles (Fe3O4) and photosan were incorporated in silica nanoparticles by microemulsion and sol-gel methods. The prepared nanoparticles were characterized by X-ray diffraction, and transmission electron microscopy. The nanoparticles possessed good biocompatibility and could cause remarkable photodynamic anti-tumor effects. These suggested that photosan-Fe3O4 nanoparticles had great potential as effective drug delivery system in targeting photodynamic therapy.

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