Study conclude that AKI appears to be a frequent complication of hyperosmolar therapy with glycerol in patients with malignant MCA infarction: we don't agree about the next study to do!

Transcranial Doppler (TCD) is a non-invasive method for assessing cerebral hemodynamics in the acute phase of stroke. We report a case of a 33-year-old man who presented with a massive left hemispheric infarct developing into “malignant” MCA infarction. TCD was utilized to monitor intracranial hemodynamics while the clinical and neuroimaging findings were used to help us in the decision to proceed with decompressive craniectomy (DC). Pre-operatively, there was reduced mean flow velocities (MFV) of the middle cerebral artery (MCA) with increasing pulsatility index (PI) ipsilateral to the infarct. The subsequent but smaller rise in the PI in the contralateral MCA was suggestive of very high intracranial pressure (ICP) from massive brain swelling. Serial TCD examinations post-operatively showed normalization of the PI, and subsequent rise in the left MCA MFV. Clinical improvement was also noted as the TCD findings improved. The asymmetry in TCD findings can be attributed to occlusion of the MCA with subsequent spontaneous recanalisation, occlusion of the MCA with subsequent recanalisation due to the DC, or initial occlusion and subsequent pressure effects on the arterioles of the MCA due to the “malignant” edema of that hemisphere that was relieved by DC. This case illustrates the value of TCD as a useful modality in monitoring intracranial hemodynamics in acute stroke.

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Cholesterol atheroembolism: an increasingly frequent complication of cardiac catheterisation

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1991.tb121135.x ◽

1991 ◽

Vol 154 (6) ◽

pp. 412-414 ◽

Cited By ~ 9

Author(s):

Hean T Ong ◽

Wayne G Elmsly ◽

Denis H Friedlander

Keyword(s):

Cardiac Catheterisation ◽

Frequent Complication

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Hyperosmolar Therapy: A Century of Treating Cerebral Edema

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2021.106704 ◽

2021 ◽

pp. 106704

Author(s):

Aaron Desai ◽

Rahul Damani

Keyword(s):

Cerebral Edema ◽

Hyperosmolar Therapy

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Invasive pulmonary aspergillosis is a frequent complication in patients with severe fever with thrombocytopenia syndrome: A retrospective study

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2021.02.088 ◽

2021 ◽

Vol 105 ◽

pp. 646-652

Author(s):

Ying Xu ◽

Mingran Shao ◽

Ning Liu ◽

Jian Tang ◽

Qin Gu ◽

...

Keyword(s):

Retrospective Study ◽

Invasive Pulmonary Aspergillosis ◽

Pulmonary Aspergillosis ◽

Frequent Complication ◽

Severe Fever

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A Central Role for Ischemia and OCTA Metrics to Follow DR Progression

Journal of Clinical Medicine ◽

10.3390/jcm10091821 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1821

Author(s):

José Cunha-Vaz

Keyword(s):

Diabetic Retinopathy ◽

Frequent Complication

Diabetic retinopathy (DR) is a frequent complication of diabetes and through its vision-threatening complications, i [...]

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AB0442 CLINICAL FEATURES OF POLYMYOSITIS AND DERMATOMYOSITIS PATIENTS WITH SEVERE DYSPHAGIA

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.2757 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1249.1-1249

Author(s):

Y. Hayashi ◽

K. Izumi ◽

S. Hama ◽

M. Higashida-Konishi ◽

M. Ushikubo ◽

...

Keyword(s):

Interstitial Pneumonia ◽

Clinical Features ◽

Clinical Characteristics ◽

Age Of Onset ◽

Inflammatory Diseases ◽

Medical Center ◽

Hospital Organization ◽

Initial Examination ◽

Severe Dysphagia ◽

Frequent Complication

Background:Polymyositis (PM) and dermatomyositis (DM) are autoimmune inflammatory diseases characterized by proximal myositis. Dysphagia has been reported to develop in 35 to 62% of PM/DM patients and known as poor prognosis factor.Objectives:The purpose of this study is to determine the clinical characteristics of PM/DM patients who present with deglutition disorder.Methods:Consecutive patients with PM/DM who visited National Hospital Organization Tokyo Medical Center between April 2010 and January 2021 are included in this study. We compared clinical features between the patients with and without dysphagia. The diagnosis of dysphagia was based on videofluorography swallow study, and dysphagia requiring gastrostomy was defined as severe dysphagia. The clinical characteristics compared in this study were following: age of onset, levels of serum creatine kinase (CK) and lactate dehydrogenase(LDH), sense of dysphagia, manual muscle test (MMT) score, and complication of malignancy or interstitial pneumonia.Results:A total of 73 patients with PM/DM were identified. Among them, 12 patients were diagnosed with dysphagia, and 5 patients developed severe dysphagia. Patients with dysphagia had the following characteristics compared to patients without dysphagia: higher levels of serum LDH (833.7 ± 500.1 U/L vs 471.9 ± 321.0 U/L, p = 0.0088), higher levels of serum CK at initial examination (6070.3 ± 7184.8 IU/L vs 1534.7 ± 2978.8 IU/L, p = 0.0086) and more frequent sense of dysphagia (90.9% vs 10.6%, p< 0.0001), lower MMT score(3.18 ± 1.07 vs 4.31 ± 0.75, p = 0.0017). In addition to those, patients with severe dysphagia presented older age of onset (mean age 69.4 ± 12.0 vs 51.7 ± 14.8, p = 0.014), more frequent complication of malignancy (80.0% vs 14.8%, p= 0.0048) and less frequent complication of interstitial pneumonia (0.0% vs 55.5%, p= 0.023).Conclusion:These results indicate that dysphagia develops frequently in PM/DM patients with higher levels of serum LDH or CK, sense of dysphagia and low MMT score. Among them, patients with elderly onset or malignancy are at risk for sever dysphagia, and should be treated carefully.Disclosure of Interests:None declared.

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Clostridium difficile-associated diarrhoea, a frequent complication in patients with acute myeloid leukaemia

Annals of Hematology ◽

10.1007/s00277-009-0772-0 ◽

2009 ◽

Vol 89 (1) ◽

pp. 9-14 ◽

Cited By ~ 44

Author(s):

Enrico Schalk ◽

Ulrich R. M. Bohr ◽

Brigitte König ◽

Katrin Scheinpflug ◽

Martin Mohren

Keyword(s):

Clostridium Difficile ◽

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Frequent Complication ◽

Clostridium Difficile Associated Diarrhoea ◽

Acute Myeloid

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Management of Persistent Air Leaks with Intrabronchial Valves

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0037-1603622 ◽

2017 ◽

Vol 66 (07) ◽

pp. 603-606

Author(s):

Andreas Hecker ◽

Konstantin Mayer ◽

Biruta Witte ◽

Matthias Hecker

Keyword(s):

Thoracic Surgery ◽

Minimal Invasive ◽

Therapeutic Approaches ◽

Air Leak ◽

Frequent Complication ◽

Less Invasive ◽

Air Leaks ◽

Prolonged Hospitalization ◽

Highly Effective ◽

Endoscopic Placement

AbstractPersistent air leaks (PALs) are regarded as a frequent complication after thoracic surgery resulting in prolonged hospitalization and increased morbidity. Several more or less invasive therapeutic approaches are available for treatment of PAL with varying degrees of success. The endoscopic placement of one-way intrabronchial valves in the segment(s) in which the air leak has been located offers a highly effective and well-tolerated minimal invasive option for patients with PAL.

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