Prospective study of viral clearance and CD4+ T-cell response in acute hepatitis C primary infection and reinfection

2006 ◽  
Vol 36 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Judith H. Aberle ◽  
Elisabeth Formann ◽  
Petra Steindl-Munda ◽  
Lukas Weseslindtner ◽  
Calin Gurguta ◽  
...  
Keyword(s):  
Hepatitis C ◽  
T Cell ◽  
Prospective Study ◽  
Acute Hepatitis ◽  
Cell Response ◽  
Primary Infection ◽  
T Cell Response ◽  
Viral Clearance ◽  
Cd4 T Cell ◽  
Acute Hepatitis C

Recurrence of hepatitis C virus after loss of virus specific CD4+ T cell response in acute hepatitis C

1998 ◽  
Vol 28 ◽  
pp. 44
Author(s):  
J.T. Gerlach ◽  
H.M. Diepolder ◽  
N.H. Grüner ◽  
M.C. Jung ◽  
R. Zachoval ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Acute Hepatitis ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Acute Hepatitis C

Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C

1999 ◽  
Vol 117 (4) ◽  
pp. 933-941 ◽  
Author(s):  
J.Tilman Gerlach ◽  
Helmut M. Diepolder ◽  
Maria–Christina Jung ◽  
Norbert H. Gruener ◽  
Winfried W. Schraut ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Acute Hepatitis ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Acute Hepatitis C

447 Reinfection with the hepatitis C virus: Kinetics of viral clearance and multi-parameter analysis of CD4+ T-cell response

2006 ◽  
Vol 44 ◽  
pp. S167 ◽  
Author(s):  
L. Weseslindtner ◽  
J.H. Aberle ◽  
C. Gurguta ◽  
P. Steindl-Munda ◽  
T. Popow-Kraupp ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Viral Clearance ◽  
Parameter Analysis ◽  
Cd4 T Cell ◽  
Kinetics Of

Discordant Role of CD4 T-Cell Response Relative to Neutralizing Antibody and CD8 T-Cell Responses in Acute Hepatitis C

2007 ◽  
Vol 132 (2) ◽  
pp. 654-666 ◽  
Author(s):  
David E. Kaplan ◽  
Kazushi Sugimoto ◽  
Kimberly Newton ◽  
Mary E. Valiga ◽  
Fusao Ikeda ◽  
...  
Keyword(s):  
Hepatitis C ◽  
T Cell ◽  
Cell Response ◽  
Neutralizing Antibody ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Acute Hepatitis C ◽  
Cell Responses

scholarly journals Pegylated interferon ? therapy in acute hepatitis C: Relation to hepatitis C virus-specific T cell response kinetics

Hepatology ◽  
2004 ◽  
Vol 39 (6) ◽  
pp. 1721-1731 ◽  
Author(s):  
Sanaa M. Kamal ◽  
Alaa Ismail ◽  
Camilla S. Graham ◽  
Qi He ◽  
Jens W. Rasenack ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Acute Hepatitis ◽  
Cell Response ◽  
Interferon Therapy ◽  
Pegylated Interferon ◽  
T Cell Response ◽  
Acute Hepatitis C

scholarly journals Lack of variant specific CD8+ T-cell response against mutant and pre-existing variants leads to outgrowth of particular clones in acute hepatitis C

2013 ◽  
Vol 10 (1) ◽  
pp. 295 ◽  
Author(s):  
Axel Ulsenheimer ◽  
Gláucia Paranhos-Baccalà ◽  
Florence Komurian-Pradel ◽  
Bijan Raziorrouh ◽  
Peter Kurktschiev ◽  
...  
Keyword(s):  
Hepatitis C ◽  
T Cell ◽  
Acute Hepatitis ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Acute Hepatitis C

scholarly journals Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

2012 ◽  
Vol 209 (1) ◽  
pp. 61-75 ◽  
Author(s):  
Julian Schulze zur Wiesch ◽  
Donatella Ciuffreda ◽  
Lia Lewis-Ximenez ◽  
Victoria Kasprowicz ◽  
Brian E. Nolan ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C ◽  
T Cell ◽  
Acute Hepatitis ◽  
Antiviral Therapy ◽  
Cd4 T Cells ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Acute Hepatitis C ◽  
Cell Responses

Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in chronically evolving infection. Here, we comprehensively characterized the breadth, specificity, and quality of the HCV-specific CD4+ T cell response in 31 patients with acute HCV infection and varying clinical outcomes. We analyzed in vitro T cell expansion in the presence of interleukin-2, and ex vivo staining with HCV peptide-loaded MHC class II tetramers. Surprisingly, broadly directed HCV-specific CD4+ T cell responses were universally detectable at early stages of infection, regardless of the clinical outcome. However, persistent viremia was associated with early proliferative defects of the HCV-specific CD4+ T cells, followed by rapid deletion of the HCV-specific response. Only early initiation of antiviral therapy was able to preserve CD4+ T cell responses in acute, chronically evolving infection. Our results challenge the paradigm that HCV persistence is the result of a failure to prime HCV-specific CD4+ T cells. Instead, broadly directed HCV-specific CD4+ T cell responses are usually generated, but rapid exhaustion and deletion of these cells occurs in the majority of patients. The data further suggest a short window of opportunity to prevent the loss of CD4+ T cell responses through antiviral therapy.

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